{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T04:09:28Z","timestamp":1777954168300,"version":"3.51.4"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2020,11,27]],"date-time":"2020-11-27T00:00:00Z","timestamp":1606435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000196","name":"Canada Foundation for Innovation","doi-asserted-by":"publisher","award":["35456"],"award-info":[{"award-number":["35456"]}],"id":[{"id":"10.13039\/501100000196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>MarkerDB is a freely available electronic database that attempts to consolidate information on all known clinical and a selected set of pre-clinical molecular biomarkers into a single resource. The database includes four major types of molecular biomarkers (chemical, protein, DNA [genetic]\u00a0and karyotypic) and four biomarker categories (diagnostic, predictive, prognostic and exposure). MarkerDB provides information such as: biomarker names and synonyms, associated conditions or pathologies, detailed disease descriptions, detailed biomarker descriptions, biomarker specificity, sensitivity and ROC curves, standard reference values (for protein and chemical markers), variants (for SNP or genetic markers), sequence information (for genetic and protein markers), molecular structures (for protein and chemical markers), tissue or biofluid sources (for protein and chemical markers), chromosomal location and structure (for genetic and karyotype markers), clinical approval status and relevant literature references. Users can browse the data by conditions, condition categories, biomarker types, biomarker categories or search by sequence similarity through the advanced search function. Currently, the database contains 142 protein biomarkers, 1089 chemical biomarkers, 154 karyotype biomarkers and 26 374 genetic markers. These are categorized into 25 560 diagnostic biomarkers, 102 prognostic biomarkers, 265 exposure biomarkers and 6746 predictive biomarkers or biomarker panels. Collectively, these markers can be used to detect, monitor or predict 670 specific human conditions which are grouped into 27 broad condition categories. MarkerDB is available at https:\/\/markerdb.ca.<\/jats:p>","DOI":"10.1093\/nar\/gkaa1067","type":"journal-article","created":{"date-parts":[[2020,10,26]],"date-time":"2020-10-26T12:10:39Z","timestamp":1603714239000},"page":"D1259-D1267","source":"Crossref","is-referenced-by-count":113,"title":["MarkerDB: an online database of molecular biomarkers"],"prefix":"10.1093","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3207-2434","authenticated-orcid":false,"given":"David S","family":"Wishart","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9,\u00a0Canada"},{"name":"Department of Computing Science, University of Alberta, Edmonton, AB T6G 2E8,\u00a0Canada"},{"name":"Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB T6G 2B7,\u00a0Canada"},{"name":"Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB T6G 2H7,\u00a0Canada"}]},{"given":"Brendan","family":"Bartok","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9,\u00a0Canada"}]},{"given":"Eponine","family":"Oler","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9,\u00a0Canada"}]},{"given":"Kevin Y H","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9,\u00a0Canada"}]},{"given":"Zachary","family":"Budinski","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9,\u00a0Canada"}]},{"given":"Mark","family":"Berjanskii","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9,\u00a0Canada"}]},{"given":"AnChi","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9,\u00a0Canada"}]},{"given":"Xuan","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9,\u00a0Canada"}]},{"given":"Michael","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9,\u00a0Canada"},{"name":"OMx Personal Health Analytics, Inc., 406\u201310158 103 St NW, Edmonton, AB T5J 0X6,\u00a0Canada"}]}],"member":"286","published-online":{"date-parts":[[2020,11,27]]},"reference":[{"key":"2021010313135784300_B1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.gpb.2017.04.001","article-title":"Disease biomarkers for precision medicine: challenges and future opportunities","volume":"15","author":"Wang","year":"2017","journal-title":"Genomics Proteomics Bioinformatics"},{"key":"2021010313135784300_B2","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1586\/14737159.3.5.573","article-title":"Breast cancer biomarkers and molecular medicine","volume":"3","author":"Ross","year":"2003","journal-title":"Expert Rev. 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