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Drug, gene, and interaction data are normalized and merged into conceptual groups. The information contained in this resource is available to users through a straightforward search interface, an application programming interface (API), and TSV data downloads. DGIdb 4.0 is the latest major version release of this database. A primary focus of this update was integration with crowdsourced efforts, leveraging the Drug Target Commons for community-contributed interaction data, Wikidata to facilitate term normalization, and export to NDEx for drug-gene interaction network representations. Seven new sources have been added since the last major version release, bringing the total number of sources included to 41. Of the previously aggregated sources, 15 have been updated. DGIdb 4.0 also includes improvements to the process of drug normalization and grouping of imported sources. Other notable updates include the introduction of a more sophisticated Query Score for interaction search results, an updated Interaction Score, the inclusion of interaction directionality, and several additional improvements to search features, data releases, licensing documentation\u00a0and the application framework.<\/jats:p>","DOI":"10.1093\/nar\/gkaa1084","type":"journal-article","created":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T15:12:20Z","timestamp":1603465940000},"page":"D1144-D1151","source":"Crossref","is-referenced-by-count":885,"title":["Integration of the Drug\u2013Gene Interaction Database (DGIdb 4.0) with open crowdsource efforts"],"prefix":"10.1093","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6978-3515","authenticated-orcid":false,"given":"Sharon L","family":"Freshour","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Oncology, Washington University School of Medicine, St Louis, MO 63110, USA"},{"name":"McDonnell Genome Institute, Washington University School of Medicine, St Louis, MO 63108, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4378-7328","authenticated-orcid":false,"given":"Susanna","family":"Kiwala","sequence":"additional","affiliation":[{"name":"McDonnell Genome Institute, Washington University School of Medicine, St Louis, MO 63108, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0890-6889","authenticated-orcid":false,"given":"Kelsy C","family":"Cotto","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Oncology, Washington University School of Medicine, St Louis, MO 63110, USA"},{"name":"McDonnell Genome Institute, Washington University School of Medicine, St Louis, MO 63108, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0944-3126","authenticated-orcid":false,"given":"Adam C","family":"Coffman","sequence":"additional","affiliation":[{"name":"McDonnell Genome Institute, Washington University School of Medicine, St Louis, MO 63108, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0197-2245","authenticated-orcid":false,"given":"Joshua F","family":"McMichael","sequence":"additional","affiliation":[{"name":"McDonnell Genome Institute, Washington University School of Medicine, St Louis, MO 63108, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4349-2442","authenticated-orcid":false,"given":"Jonathan J","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Oncology, Washington University School of Medicine, St Louis, MO 63110, USA"},{"name":"McDonnell Genome Institute, Washington University School of Medicine, St Louis, MO 63108, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6388-446X","authenticated-orcid":false,"given":"Malachi","family":"Griffith","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Oncology, Washington University School of Medicine, St Louis, MO 63110, USA"},{"name":"McDonnell Genome Institute, Washington University School of Medicine, St Louis, MO 63108, USA"},{"name":"Department of Genetics, Washington University School of Medicine, St Louis, MO 63110, USA"},{"name":"Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0843-4271","authenticated-orcid":false,"given":"Obi\u00a0L","family":"Griffith","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Oncology, Washington University School of Medicine, St Louis, MO 63110, USA"},{"name":"McDonnell Genome Institute, Washington University School of Medicine, St Louis, MO 63108, USA"},{"name":"Department of Genetics, Washington University School of Medicine, St Louis, MO 63110, USA"},{"name":"Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2502-8961","authenticated-orcid":false,"given":"Alex H","family":"Wagner","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Oncology, Washington University School of Medicine, St Louis, MO 63110, USA"},{"name":"McDonnell Genome Institute, Washington University School of Medicine, St Louis, MO 63108, USA"},{"name":"The Steve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH 43215, USA"},{"name":"Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH 43210, USA"}]}],"member":"286","published-online":{"date-parts":[[2020,11,25]]},"reference":[{"key":"2021010313131467700_B1","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1038\/nmeth.2689","article-title":"DGIdb: mining the druggable genome","volume":"10","author":"Griffith","year":"2013","journal-title":"Nat. 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