{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T22:30:27Z","timestamp":1775514627420,"version":"3.50.1"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2020,11,27]],"date-time":"2020-11-27T00:00:00Z","timestamp":1606435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008522","name":"UIC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008522","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>MoonProt 3.0 (http:\/\/moonlightingproteins.org) is an updated open-access database storing expert-curated annotations for moonlighting proteins. Moonlighting proteins have two or more physiologically relevant distinct biochemical or biophysical functions performed by a single polypeptide chain. Here, we describe an expansion in the database since our previous report in the Database Issue of Nucleic Acids Research in 2018. For this release, the number of proteins annotated has been expanded to over 500 proteins and dozens of protein annotations have been updated with additional information, including more structures in the Protein Data Bank, compared with version 2.0. The new entries include more examples from humans, plants and archaea, more proteins involved in disease and proteins with different combinations of functions. More kinds of information about the proteins and the species in which they have multiple functions has been added, including CATH and SCOP classification of structure, known and predicted disorder, predicted transmembrane helices, type of organism, relationship of the protein to disease, and relationship of organism to cause of disease.<\/jats:p>","DOI":"10.1093\/nar\/gkaa1101","type":"journal-article","created":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T12:07:35Z","timestamp":1604232455000},"page":"D368-D372","source":"Crossref","is-referenced-by-count":65,"title":["MoonProt 3.0: an update of the moonlighting proteins database"],"prefix":"10.1093","volume":"49","author":[{"given":"Chang","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607, USA"},{"name":"Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA"}]},{"given":"Haipeng","family":"Liu","sequence":"additional","affiliation":[{"name":"Center for Biomolecular Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA"}]},{"given":"Shadi","family":"Zabad","sequence":"additional","affiliation":[{"name":"Department of Computer Science, McGill University, Montreal, QC, Canada"}]},{"given":"Nina","family":"Rivera","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA"}]},{"given":"Emily","family":"Rowin","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA"}]},{"given":"Maheen","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA"}]},{"given":"Stephanie M","family":"Gomez\u00a0De\u00a0Jesus","sequence":"additional","affiliation":[{"name":"Universidad de Puerto Rico en Cayey, Cayey, PR 00736, USA"}]},{"given":"Paola S","family":"Llin\u00e1s\u00a0Santos","sequence":"additional","affiliation":[{"name":"Universidad de Puerto Rico en Cayey, Cayey, PR 00736, USA"}]},{"given":"Karyna","family":"Kravchenko","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Bioengineering, V. N. Karazin Kharkiv National University, IL\u00a061002, Ukraine"}]},{"given":"Mariia","family":"Mikhova","sequence":"additional","affiliation":[{"name":"Minot State University, Minot, ND\u00a058707, USA"}]},{"given":"Sophia","family":"Ketterer","sequence":"additional","affiliation":[{"name":"Cold Spring Harbor High School, Cold Spring Harbor, NY 11724, USA"}]},{"given":"Annabel","family":"Shen","sequence":"additional","affiliation":[{"name":"Cold Spring Harbor High School, Cold Spring Harbor, NY 11724, USA"}]},{"given":"Sophia","family":"Shen","sequence":"additional","affiliation":[{"name":"Cold Spring Harbor High School, Cold Spring Harbor, NY 11724, USA"}]},{"given":"Erin","family":"Navas","sequence":"additional","affiliation":[{"name":"Northport High School, Northport, NY 11768, USA"}]},{"given":"Bryan","family":"Horan","sequence":"additional","affiliation":[{"name":"Northport High School, Northport, NY 11768, USA"}]},{"given":"Jaak","family":"Raudsepp","sequence":"additional","affiliation":[{"name":"Cold Spring Harbor High School, Cold Spring Harbor, NY 11724, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2147-3638","authenticated-orcid":false,"given":"Constance","family":"Jeffery","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607, USA"},{"name":"Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA"}]}],"member":"286","published-online":{"date-parts":[[2020,11,27]]},"reference":[{"key":"2021010313123606700_B1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S0968-0004(98)01335-8","article-title":"Moonlighting proteins","volume":"24","author":"Jeffery","year":"1999","journal-title":"Trends Biochem. 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