{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T12:33:59Z","timestamp":1775133239579,"version":"3.50.1"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T00:00:00Z","timestamp":1606953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Warshel Institute for Computational Biology"},{"name":"Shenzhen Ganghong Group Co., Ltd."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>DNA methylation is an important epigenetic regulator in gene expression and has several roles in cancer and disease progression. MethHC version 2.0 (MethHC 2.0) is an integrated and web-based resource focusing on the aberrant methylomes of human diseases, specifically cancer. This paper presents an updated implementation of MethHC 2.0 by incorporating additional DNA methylomes and transcriptomes from several public repositories, including 33 human cancers, over 50\u00a0118 microarray and RNA sequencing data from TCGA and GEO, and accumulating up to 3586 manually curated data from &amp;gt;7000 collected published literature with experimental evidence. MethHC 2.0 has also been equipped with enhanced data annotation functionality and a user-friendly web interface for data presentation, search, and visualization. Provided features include clinical-pathological data, mutation and copy number variation, multiplicity of information (gene regions, enhancer regions, and CGI regions), and circulating tumor DNA methylation profiles, available for research such as biomarker panel design, cancer comparison, diagnosis, prognosis, therapy study and identifying potential epigenetic biomarkers. MethHC 2.0 is now available at http:\/\/awi.cuhk.edu.cn\/\u223cMethHC.<\/jats:p>","DOI":"10.1093\/nar\/gkaa1104","type":"journal-article","created":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T20:17:37Z","timestamp":1604434657000},"page":"D1268-D1275","source":"Crossref","is-referenced-by-count":43,"title":["MethHC 2.0: information repository of DNA methylation and gene expression in human cancer"],"prefix":"10.1093","volume":"49","author":[{"given":"Hsi-Yuan","family":"Huang","sequence":"first","affiliation":[{"name":"School of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen, Longgang District, Shenzhen, Guangdong Province\u00a0518172, China"},{"name":"Warshel Institute for Computational Biology, The Chinese University of Hong Kong, Shenzhen, Longgang District, Shenzhen, Guangdong Province\u00a0518172, China"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"School of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen, Longgang District, Shenzhen, Guangdong Province\u00a0518172, China"}]},{"given":"Yun","family":"Tang","sequence":"additional","affiliation":[{"name":"School of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen, Longgang District, Shenzhen, Guangdong Province\u00a0518172, China"}]},{"given":"Yi-Xian","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen, Longgang District, Shenzhen, Guangdong Province\u00a0518172, China"}]},{"given":"Yi-Gang","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen, Longgang District, Shenzhen, Guangdong Province\u00a0518172, China"}]},{"given":"Yue-Yang","family":"Xie","sequence":"additional","affiliation":[{"name":"School of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen, Longgang District, Shenzhen, Guangdong Province\u00a0518172, China"}]},{"given":"Zhe-Yuan","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Data Science, The Chinese University of Hong Kong, Shenzhen, Longgang District, Shenzhen, Guangdong Province\u00a0518172, China"}]},{"given":"Xin-Yi","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen, Longgang District, Shenzhen, Guangdong Province\u00a0518172, China"}]},{"given":"Si-Yuan","family":"Ding","sequence":"additional","affiliation":[{"name":"School of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen, Longgang District, Shenzhen, Guangdong Province\u00a0518172, China"}]},{"given":"Meng-Fan","family":"Luo","sequence":"additional","affiliation":[{"name":"School of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen, Longgang District, Shenzhen, Guangdong Province\u00a0518172, China"}]},{"given":"Chen-Nan","family":"Jin","sequence":"additional","affiliation":[{"name":"School of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen, Longgang District, Shenzhen, Guangdong Province\u00a0518172, China"}]},{"given":"Le-Shan","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen, Longgang District, Shenzhen, Guangdong Province\u00a0518172, China"}]},{"given":"Jia-Tong","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen, Longgang District, Shenzhen, Guangdong Province\u00a0518172, China"}]},{"given":"Ying","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen, Longgang District, Shenzhen, Guangdong Province\u00a0518172, China"}]},{"given":"Yang-Chi-Dung","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen, Longgang District, Shenzhen, Guangdong Province\u00a0518172, China"},{"name":"Warshel Institute for Computational Biology, The Chinese University of Hong Kong, Shenzhen, Longgang District, Shenzhen, Guangdong Province\u00a0518172, China"}]},{"given":"Hsiao-Chin","family":"Hong","sequence":"additional","affiliation":[{"name":"School of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen, Longgang District, Shenzhen, Guangdong Province\u00a0518172, China"},{"name":"Warshel Institute for Computational Biology, The Chinese University of Hong Kong, Shenzhen, Longgang District, Shenzhen, Guangdong Province\u00a0518172, China"}]},{"given":"Hua-Li","family":"Zuo","sequence":"additional","affiliation":[{"name":"School of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen, Longgang District, Shenzhen, Guangdong Province\u00a0518172, China"},{"name":"Warshel Institute for Computational Biology, The Chinese University of Hong Kong, Shenzhen, Longgang District, Shenzhen, Guangdong Province\u00a0518172, China"}]},{"given":"Si-Yao","family":"Hu","sequence":"additional","affiliation":[{"name":"School of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen, Longgang District, Shenzhen, Guangdong Province\u00a0518172, China"},{"name":"Warshel Institute for Computational Biology, The Chinese University of Hong Kong, Shenzhen, Longgang District, Shenzhen, Guangdong Province\u00a0518172, China"}]},{"given":"Pei-Yi","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen, Longgang District, Shenzhen, Guangdong Province\u00a0518172, China"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[{"name":"School of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen, Longgang District, Shenzhen, Guangdong Province\u00a0518172, China"},{"name":"Warshel Institute for Computational Biology, The Chinese University of Hong Kong, Shenzhen, Longgang District, Shenzhen, Guangdong Province\u00a0518172, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2857-7023","authenticated-orcid":false,"given":"Hsien-Da","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen, Longgang District, Shenzhen, Guangdong Province\u00a0518172, China"},{"name":"Warshel Institute for Computational Biology, The Chinese University of Hong Kong, Shenzhen, Longgang District, Shenzhen, Guangdong Province\u00a0518172, China"}]}],"member":"286","published-online":{"date-parts":[[2020,12,3]]},"reference":[{"key":"2021010313140076500_B1","doi-asserted-by":"crossref","first-page":"4632","DOI":"10.1200\/JCO.2004.07.151","article-title":"DNA methylation and cancer","volume":"22","author":"Das","year":"2004","journal-title":"J. Clin. Oncol."},{"key":"2021010313140076500_B2","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/s41580-019-0159-6","article-title":"The diverse roles of DNA methylation in mammalian development and disease","volume":"20","author":"Greenberg","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2021010313140076500_B3","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/nrc1045","article-title":"The power and the promise of DNA methylation markers","volume":"3","author":"Laird","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"2021010313140076500_B4","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.12688\/f1000research.21584.1","article-title":"DNA methylation changes in biomarker loci occur early in cancer progression","volume":"8","author":"Vrba","year":"2019","journal-title":"F1000Research"},{"key":"2021010313140076500_B5","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1080\/15592294.2019.1638701","article-title":"DNA hypermethylation in disease: mechanisms and clinical relevance","volume":"14","author":"Ehrlich","year":"2019","journal-title":"Epigenetics"},{"key":"2021010313140076500_B6","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/978-1-4419-9967-2_2","volume-title":"Epigenetic Alterations in Oncogenesis","author":"Ehrlich","year":"2013"},{"key":"2021010313140076500_B7","first-page":"2599","article-title":"Scrophularia atropatana extract reverses tp53 gene promoter hypermethylation and decreases survivin antiapoptotic gene expression in breast cancer cells","volume":"19","author":"Fakhr","year":"2018","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"2021010313140076500_B8","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s00428-012-1286-z","article-title":"BRCA1-methylated sporadic breast cancers are BRCA-like in showing a basal phenotype and absence of ER expression","volume":"461","author":"Bal","year":"2012","journal-title":"Virchows. Arch."},{"key":"2021010313140076500_B9","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s11010-012-1240-z","article-title":"Curcumin causes promoter hypomethylation and increased expression of FANCF gene in SiHa cell line","volume":"365","author":"Parashar","year":"2012","journal-title":"Mol. Cell. Biochem."},{"key":"2021010313140076500_B10","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1139\/bcb-2012-0044","article-title":"The epigenetic potentials of dietary polyphenols in prostate cancer management","volume":"91","author":"Abbas","year":"2013","journal-title":"Biochem. Cell. Biol."},{"key":"2021010313140076500_B11","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/onc.2011.255","article-title":"Epigenetic repression of E-cadherin expression by hepatitis B virus x antigen in liver cancer","volume":"31","author":"Arzumanyan","year":"2012","journal-title":"Oncogene"},{"key":"2021010313140076500_B12","first-page":"3772","article-title":"Copine 5 expression predicts prognosis following curative resection of esophageal squamous cell carcinoma","volume":"40","author":"Umeda","year":"2018","journal-title":"Oncol. Rep."},{"key":"2021010313140076500_B13","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1515\/bmc-2016-0011","article-title":"High-throughput sequencing offers new insights into 5-hydroxymethylcytosine","volume":"7","author":"Pang","year":"2016","journal-title":"Biomol. Concepts"},{"key":"2021010313140076500_B14","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s00428-009-0847-2","article-title":"Genome-scale approaches to the epigenetics of common human disease","volume":"456","author":"Feinberg","year":"2010","journal-title":"Virchows. Arch."},{"key":"2021010313140076500_B15","doi-asserted-by":"crossref","first-page":"18008","DOI":"10.1038\/hgv.2018.8","article-title":"iMETHYL: an integrative database of human DNA methylation, gene expression, and genomic variation","volume":"5","author":"Komaki","year":"2018","journal-title":"Hum. Genome Variation"},{"key":"2021010313140076500_B16","doi-asserted-by":"crossref","first-page":"D288","DOI":"10.1093\/nar\/gkx1139","article-title":"MethBank 3.0: a database of DNA methylomes across a variety of species","volume":"46","author":"Li","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"2021010313140076500_B17","doi-asserted-by":"crossref","first-page":"D1030","DOI":"10.1093\/nar\/gkr1169","article-title":"DiseaseMeth: a human disease methylation database","volume":"40","author":"Lv","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"2021010313140076500_B18","doi-asserted-by":"crossref","first-page":"D888","DOI":"10.1093\/nar\/gkw1123","article-title":"DiseaseMeth version 2.0: a major expansion and update of the human disease methylation database","volume":"45","author":"Xiong","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"2021010313140076500_B19","doi-asserted-by":"crossref","first-page":"D836","DOI":"10.1093\/nar\/gkm730","article-title":"MethyCancer: the database of human DNA methylation and cancer","volume":"36","author":"He","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"2021010313140076500_B20","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1093\/nar\/29.1.270","article-title":"MethDB\u2014a public database for DNA methylation data","volume":"29","author":"Grunau","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"2021010313140076500_B21","doi-asserted-by":"crossref","first-page":"D75","DOI":"10.1093\/nar\/gkq942","article-title":"NGSmethDB: a database for next-generation sequencing single-cytosine-resolution DNA methylation data","volume":"39","author":"Hackenberg","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"2021010313140076500_B22","doi-asserted-by":"crossref","first-page":"D97","DOI":"10.1093\/nar\/gkw996","article-title":"NGSmethDB 2017: Enhanced methylomes and differential methylation","volume":"45","author":"Lebr\u00f3n","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"2021010313140076500_B23","doi-asserted-by":"crossref","first-page":"D842","DOI":"10.1093\/nar\/gkm788","article-title":"PubMeth: a cancer methylation database combining text-mining and expert annotation","volume":"36","author":"Ongenaert","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"2021010313140076500_B24","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.gene.2012.11.032","article-title":"MENT: methylation and expression database of normal and tumor tissues","volume":"518","author":"Baek","year":"2013","journal-title":"Gene"},{"key":"2021010313140076500_B25","doi-asserted-by":"crossref","first-page":"D856","DOI":"10.1093\/nar\/gku1151","article-title":"MethHC: a database of DNA methylation and gene expression in human cancer","volume":"43","author":"Huang","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"2021010313140076500_B26","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1158\/1078-0432.CCR-09-1736","article-title":"MicroRNA expression differentiates histology and predicts survival of lung cancer","volume":"16","author":"Landi","year":"2010","journal-title":"Clin. Cancer Res."},{"key":"2021010313140076500_B27","doi-asserted-by":"crossref","first-page":"4443","DOI":"10.1158\/0008-5472.CAN-08-4025","article-title":"Epigenetic silencing of the tumor suppressor microRNA Hsa-miR-124a regulates CDK6 expression and confers a poor prognosis in acute lymphoblastic leukemia","volume":"69","author":"Agirre","year":"2009","journal-title":"Cancer Res."},{"key":"2021010313140076500_B28","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1136\/gut.2011.239145","article-title":"The putative tumour suppressor microRNA-124 modulates hepatocellular carcinoma cell aggressiveness by repressing ROCK2 and EZH2","volume":"61","author":"Zheng","year":"2012","journal-title":"Gut"},{"key":"2021010313140076500_B29","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1186\/1476-4598-9-167","article-title":"Methylation-mediated silencing and tumour suppressive function of hsa-miR-124 in cervical cancer","volume":"9","author":"Wilting","year":"2010","journal-title":"Mol. Cancer"},{"key":"2021010313140076500_B30","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1101\/gad.1974211","article-title":"MicroRNA-335 inhibits tumor reinitiation and is silenced through genetic and epigenetic mechanisms in human breast cancer","volume":"25","author":"Png","year":"2011","journal-title":"Genes Dev."},{"key":"2021010313140076500_B31","doi-asserted-by":"crossref","first-page":"e54398","DOI":"10.1371\/journal.pone.0054398","article-title":"miRNA gene promoters are frequent targets of aberrant DNA methylation in human breast cancer","volume":"8","author":"Vrba","year":"2013","journal-title":"PLoS One"},{"key":"2021010313140076500_B32","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1007\/s00441-014-1793-0","article-title":"Aberrant DNA methylation of microRNA genes in human breast cancer\u2013a critical appraisal","volume":"356","author":"Lehmann","year":"2014","journal-title":"Cell Tissue Res."},{"key":"2021010313140076500_B33","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/978-3-319-42059-2_6","volume-title":"Non-coding RNAs in Colorectal Cancer","author":"Kaur","year":"2016"},{"key":"2021010313140076500_B34","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1158\/1940-6207.CAPR-12-0501","article-title":"DNA methylation biomarkers for noninvasive diagnosis of colorectal cancer","volume":"6","author":"Carmona","year":"2013","journal-title":"Cancer Prev. Res."},{"key":"2021010313140076500_B35","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/s41571-018-0004-4","article-title":"Analysis of DNA methylation in cancer: location revisited","volume":"15","author":"Koch","year":"2018","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"2021010313140076500_B36","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.cell.2018.02.052","article-title":"An integrated TCGA pan-cancer clinical data resource to drive high-quality survival outcome analytics","volume":"173","author":"Liu","year":"2018","journal-title":"Cell"},{"key":"2021010313140076500_B37","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/nar\/30.1.207","article-title":"Gene Expression Omnibus: NCBI gene expression and hybridization array data repository","volume":"30","author":"Edgar","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"2021010313140076500_B38","first-page":"D756","article-title":"UCSC Genome Browser enters 20th year","volume":"48","author":"Lee","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"2021010313140076500_B39","doi-asserted-by":"crossref","first-page":"9345","DOI":"10.1093\/nar\/gkr604","article-title":"Identifying transcriptional start sites of human microRNAs based on high-throughput sequencing data","volume":"39","author":"Chien","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"2021010313140076500_B40","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1038\/s41467-019-09937-w","article-title":"Chromatin dysregulation and DNA methylation at transcription start sites associated with transcriptional repression in cancers (vol 10, 2188, 2019)","volume":"10","author":"Ando","year":"2019","journal-title":"Nat. Commun."},{"key":"2021010313140076500_B41","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1126\/science.1659741","article-title":"Tumor suppressor genes","volume":"254","author":"Weinberg","year":"1991","journal-title":"Science"},{"key":"2021010313140076500_B42","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.ccr.2014.07.028","article-title":"Gene body methylation can alter gene expression and is a therapeutic target in cancer","volume":"26","author":"Yang","year":"2014","journal-title":"Cancer Cell"},{"key":"2021010313140076500_B43","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: Kyoto encyclopedia of genes and genomes","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"2021010313140076500_B44","first-page":"D58","article-title":"EnhancerAtlas 2.0: an updated resource with enhancer annotation in 586 tissue\/cell types across nine species","volume":"48","author":"Gao","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"2021010313140076500_B45","doi-asserted-by":"crossref","first-page":"15034","DOI":"10.1038\/s41598-019-51018-x","article-title":"Differentially methylated super-enhancers regulate target gene expression in human cancer","volume":"9","author":"Flam","year":"2019","journal-title":"Sci. Rep."},{"key":"2021010313140076500_B46","doi-asserted-by":"crossref","first-page":"R157","DOI":"10.1530\/ERC-15-0369","article-title":"Methylated circulating tumor DNA in blood: power in cancer prognosis and response","volume":"23","author":"Warton","year":"2016","journal-title":"Endocr. Relat. Cancer"},{"key":"2021010313140076500_B47","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s13073-018-0548-z","article-title":"Integrative analysis of DNA methylation and gene expression reveals hepatocellular carcinoma-specific diagnostic biomarkers","volume":"10","author":"Cheng","year":"2018","journal-title":"Genome Med"},{"key":"2021010313140076500_B48","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J. Clin."}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/nar\/article-pdf\/49\/D1\/D1268\/35364237\/gkaa1104.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/nar\/article-pdf\/49\/D1\/D1268\/35364237\/gkaa1104.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,3]],"date-time":"2021-01-03T18:20:25Z","timestamp":1609698025000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article\/49\/D1\/D1268\/6018433"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,3]]},"references-count":48,"journal-issue":{"issue":"D1","published-online":{"date-parts":[[2020,12,3]]},"published-print":{"date-parts":[[2021,1,8]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gkaa1104","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,1,8]]},"published":{"date-parts":[[2020,12,3]]}}}