{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T21:01:05Z","timestamp":1775509265270,"version":"3.50.1"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"W1","license":[{"start":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T00:00:00Z","timestamp":1587427200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2019YFA0904300"],"award-info":[{"award-number":["2019YFA0904300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFA0900700"],"award-info":[{"award-number":["2018YFA0900700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFC1601702"],"award-info":[{"award-number":["2017YFC1601702"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31700081"],"award-info":[{"award-number":["31700081"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31570092"],"award-info":[{"award-number":["31570092"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Scientific Research Conditions and Technical Support System Program","award":["ZSYS-016"],"award-info":[{"award-number":["ZSYS-016"]}]},{"name":"CAS STS program","award":["QYZDB-SSW-SMC012"],"award-info":[{"award-number":["QYZDB-SSW-SMC012"]}]},{"name":"International Partnership Program of Chinese Academy of Sciences of China","award":["153D31KYSB20170121"],"award-info":[{"award-number":["153D31KYSB20170121"]}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin","doi-asserted-by":"publisher","award":["15JCYBJC54300"],"award-info":[{"award-number":["15JCYBJC54300"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To increase the number of value-added chemicals that can be produced by metabolic engineering and synthetic biology, constructing metabolic space with novel reactions\/pathways is crucial. However, with the large number of reactions that existed in the metabolic space and complicated metabolisms within hosts, identifying novel pathways linking two molecules or heterologous pathways when engineering a host to produce a target molecule is an arduous task. Hence, we built a user-friendly web server, novoPathFinder, which has several features: (i) enumerate novel pathways between two specified molecules without considering hosts; (ii) construct heterologous pathways with known or putative reactions for producing target molecule within Escherichia coli or yeast without giving precursor; (iii) estimate novel pathways with considering several categories, including enzyme promiscuity, Synthetic Complex Score (SCScore) and LD50 of intermediates, overall stoichiometric conversions, pathway length, theoretical yields and thermodynamic feasibility. According to the results, novoPathFinder is more capable to recover experimentally validated pathways when comparing other rule-based web server tools. Besides, more efficient pathways with novel reactions could also be retrieved for further experimental exploration. novoPathFinder is available at http:\/\/design.rxnfinder.org\/novopathfinder\/.<\/jats:p>","DOI":"10.1093\/nar\/gkaa230","type":"journal-article","created":{"date-parts":[[2020,3,28]],"date-time":"2020-03-28T12:09:59Z","timestamp":1585397399000},"page":"W477-W487","source":"Crossref","is-referenced-by-count":40,"title":["novoPathFinder: a webserver of designing novel-pathway with integrating GEM-model"],"prefix":"10.1093","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5581-8403","authenticated-orcid":false,"given":"Shaozhen","family":"Ding","sequence":"first","affiliation":[{"name":"CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Shanghai\u00a0200031, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Tian","sequence":"first","affiliation":[{"name":"School of Biology and Pharmaceutical Engineering, Wuhan Polytechnic University, Wuhan, Hubei 430023, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengli","family":"Cai","sequence":"first","affiliation":[{"name":"CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Shanghai\u00a0200031, People's Republic of China"},{"name":"Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dachuan","family":"Zhang","sequence":"first","affiliation":[{"name":"CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Shanghai\u00a0200031, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingxiang","family":"Cheng","sequence":"first","affiliation":[{"name":"CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Shanghai\u00a0200031, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dandan","family":"Sun","sequence":"first","affiliation":[{"name":"CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Shanghai\u00a0200031, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Le","family":"Yuan","sequence":"first","affiliation":[{"name":"Department of Biology and Biological Engineering, Chalmers University of Technology, Kemiv\u00e4gen 10, SE412 96 Gothenburg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junni","family":"Chen","sequence":"first","affiliation":[{"name":"Wuhan LifeSynther Science and Technology Co. Limited, Wuhan\u00a0430070, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weizhong","family":"Tu","sequence":"first","affiliation":[{"name":"Wuhan LifeSynther Science and Technology Co. Limited, Wuhan\u00a0430070, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-Qing","family":"Wei","sequence":"first","affiliation":[{"name":"State Key Laboratory of Microbial Metabolism (Shanghai Jiao Tong University), Shanghai\u00a0200240, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5213-472X","authenticated-orcid":false,"given":"Qian-Nan","family":"Hu","sequence":"first","affiliation":[{"name":"CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Shanghai\u00a0200031, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,4,20]]},"reference":[{"key":"2020062614040084400_B1","doi-asserted-by":"crossref","first-page":"e7","DOI":"10.1093\/pcp\/pct176","article-title":"KNApSAcK metabolite activity database for retrieving the relationships between metabolites and biological activities","volume":"55","author":"Nakamura","year":"2014","journal-title":"Plant Cell Physiol."},{"key":"2020062614040084400_B2","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1126\/science.1191652","article-title":"Isoprenoid pathway optimization for taxol precursor overproduction in Escherichia coli","volume":"330","author":"Ajikumar","year":"2010","journal-title":"Science"},{"key":"2020062614040084400_B3","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/nature06450","article-title":"Non-fermentative pathways for synthesis of branched-chain higher alcohols as biofuels","volume":"451","author":"Atsumi","year":"2008","journal-title":"Nat. Lett."},{"key":"2020062614040084400_B4","doi-asserted-by":"crossref","first-page":"7814","DOI":"10.1128\/AEM.01140-07","article-title":"Engineered synthetic pathway for isopropanol production in Escherichia coli","volume":"73","author":"Hanai","year":"2007","journal-title":"Appl. Environ. Microbiol."},{"key":"2020062614040084400_B5","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s10295-005-0038-3","article-title":"Redesign, synthesis and functional expression of the 6-deoxyerythronolide B polyketide synthase gene cluster","volume":"33","author":"Menzella","year":"2006","journal-title":"J. Ind. Microbiol. Biotechnol."},{"key":"2020062614040084400_B6","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/nature08721","article-title":"Microbial production of fatty-acid-derived fuels and chemicals from plant biomass","volume":"463","author":"Steen","year":"2010","journal-title":"Nat. Lett."},{"key":"2020062614040084400_B7","doi-asserted-by":"crossref","first-page":"20683","DOI":"10.1073\/pnas.0809084105","article-title":"Engineered biosynthesis of bacterial aromatic polyketides in Escherichia coli","volume":"105","author":"Zhang","year":"2008","journal-title":"Proc. Natl Acad. Sci. U.S.A."},{"key":"2020062614040084400_B8","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1039\/C6NP00018E","article-title":"Bioinformatics for the synthetic biology of natural products: integrating across the Design\u2013Build\u2013 Test cycle","volume":"33","author":"Carbonell","year":"2016","journal-title":"Nat. Prod. Rep."},{"key":"2020062614040084400_B9","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.ymben.2017.12.002","article-title":"RetroPath2.0: A retrosynthesis workflow for metabolic engineers","volume":"45","author":"Del\u00e9pinea","year":"2018","journal-title":"Metab. Eng."},{"key":"2020062614040084400_B10","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1093\/nar\/gky1048","article-title":"BRENDA in 2019: a European ELIXIR core data resource","volume":"47","author":"Jeske","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"2020062614040084400_B11","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1126\/science.1216861","article-title":"Network context and selection in the evolution to enzyme specificity","volume":"337","author":"Nam","year":"2012","journal-title":"Science"},{"key":"2020062614040084400_B12","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1093\/nar\/gkw1092","article-title":"KEGG: new perspectives on genomes, pathways, diseases and drugs","volume":"45","author":"Kanehisa","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"2020062614040084400_B13","doi-asserted-by":"crossref","first-page":"D415","DOI":"10.1093\/nar\/gkw990","article-title":"Updates in Rhea \u2013 an expert curated resource of biochemical reactions","volume":"4","author":"Morgat","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"2020062614040084400_B14","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1093\/bioinformatics\/btr413","article-title":"RxnFinder: biochemical reaction search engines using molecular structures, molecular fragments and reaction similarity","volume":"27","author":"Hu","year":"2011","journal-title":"Bioinformatics"},{"key":"2020062614040084400_B15","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.coisb.2019.04.004","article-title":"Retrosynthetic design of metabolic pathways to chemicals not found in nature","volume":"14","author":"Lin","year":"2019","journal-title":"Curr. Opin. Syst. Biol."},{"key":"2020062614040084400_B16","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.cbpa.2015.06.025","article-title":"Design of computational retrobiosynthesis tools for the design of de novo synthetic pathways","volume":"28","author":"Hadadi","year":"2015","journal-title":"Curr. Opin. Chem. Biol."},{"key":"2020062614040084400_B17","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/978-1-62703-299-5_9","article-title":"Retrosynthetic design of heterologous pathways","volume":"985","author":"Carbonell","year":"2013","journal-title":"Methods Mol. Biol."},{"key":"2020062614040084400_B18","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1093\/nar\/gkq318","article-title":"PathPred: an enzyme-catalyzed metabolic pathway prediction server","volume":"38","author":"Moriya","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"2020062614040084400_B19","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1093\/bioinformatics\/bti213","article-title":"Exploring the diversity of complex metabolic networks","volume":"21","author":"Hatzimanikatis","year":"2005","journal-title":"Bioinformatics"},{"key":"2020062614040084400_B20","doi-asserted-by":"crossref","first-page":"3955","DOI":"10.1093\/bioinformatics\/btx481","article-title":"Predicting novel metabolic pathways through subgraph mining","volume":"15","author":"Sankar","year":"2017","journal-title":"Bioinformatics"},{"key":"2020062614040084400_B21","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1093\/bioinformatics\/btu265","article-title":"Metabolome-scale prediction of intermediate compounds in multistep metabolic pathways with a recursive supervised approach","volume":"30","author":"Kotera","year":"2014","journal-title":"Bioinformatics"},{"key":"2020062614040084400_B22","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/s41467-017-02362-x","article-title":"Pathway design using de novo steps through uncharted biochemical spaces","volume":"9","author":"Kumar","year":"2018","journal-title":"Nat. Commun."},{"key":"2020062614040084400_B23","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1038\/nprot.2011.308","article-title":"Quantitative prediction of cellular metabolism with constraint-based models: The COBRA Toolbox v2.0","volume":"6","author":"Schellenberger","year":"2011","journal-title":"Nat. Protoc."},{"key":"2020062614040084400_B24","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1093\/nar\/gkv1049","article-title":"BiGG Models: A platform for integrating, standardizing and sharing genome-scale models","volume":"44","author":"King","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"2020062614040084400_B25","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.ymben.2014.07.009","article-title":"Generation of an atlas for commodity chemical production in Escherichia coli and a novel pathway prediction algorithm, GEM-Path","volume":"25","author":"Campodonico","year":"2014","journal-title":"Metab. Eng."},{"key":"2020062614040084400_B26","doi-asserted-by":"crossref","first-page":"16009","DOI":"10.1038\/srep16009","article-title":"Designing overall stoichiometric conversions and intervening metabolic reactions","volume":"5","author":"Chowdhury","year":"2015","journal-title":"Sci. Rep."},{"key":"2020062614040084400_B27","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1093\/nar\/gkr874","article-title":"eQuilibrator\u2014the biochemical thermodynamics calculator","volume":"40","author":"Flamholz","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"2020062614040084400_B28","doi-asserted-by":"crossref","first-page":"4583","DOI":"10.1021\/acs.joc.9b00735","article-title":"Molecular complexity as a driver for chemical process innovation in the pharmaceutical industry","volume":"84","author":"Caille","year":"2019","journal-title":"J. Org. Chem."},{"key":"2020062614040084400_B29","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s13321-018-0283-x","article-title":"ADMETlab: a platform for systematic ADMET evaluation based on a comprehensively collected ADMET database","volume":"10","author":"Dong","year":"2018","journal-title":"J. Cheminformatics"},{"key":"2020062614040084400_B30","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1021\/acssynbio.6b00054","article-title":"ATLAS of biochemistry: a repository of all possible biochemical reactions for synthetic biology and metabolic engineering studies","volume":"5","author":"Hadadi","year":"2016","journal-title":"ACS Syntth. Biol."},{"key":"2020062614040084400_B31","doi-asserted-by":"crossref","first-page":"D1214","DOI":"10.1093\/nar\/gkv1031","article-title":"ChEBI in 2016: improved services and an expanding collection of metabolites","volume":"44","author":"Hastings","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"2020062614040084400_B32","doi-asserted-by":"crossref","first-page":"D506","DOI":"10.1093\/nar\/gky1049","article-title":"UniProt: a worldwide hub of protein knowledg","volume":"47","author":"Consortium","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"2020062614040084400_B33","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1021\/ci700006f","article-title":"Systematic analysis of enzyme-catalyzed reaction patterns and prediction of microbial biodegradation pathways","volume":"47","author":"Oh","year":"2007","journal-title":"J.Chem.Inf. Model"},{"key":"2020062614040084400_B34","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/BFb0051317","article-title":"An algebraic model of constitutional chemistry as a basis for chemical computer programs","volume":"39\/1","author":"Dugundji","year":"1973","journal-title":"Comput. Chem."},{"key":"2020062614040084400_B35","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s13321-017-0220-4","article-title":"The Chemistry Development Kit (CDK) v2.0: atom typing, depiction, molecular formulas, and substructure searching","volume":"9","author":"Willighagen","year":"2017","journal-title":"J. Cheminformatics"},{"key":"2020062614040084400_B36","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1002\/wcms.1140","article-title":"Automatic reaction mapping and reaction center detection","volume":"3","author":"Chen","year":"2013","journal-title":"WIRES Comput. Sci."},{"key":"2020062614040084400_B37","doi-asserted-by":"crossref","first-page":"3522","DOI":"10.1093\/bioinformatics\/btw491","article-title":"ReactPRED: a tool to predict and analyze biochemical reactions","volume":"32","author":"Sivakumar","year":"2016","journal-title":"Bioinformatics"},{"key":"2020062614040084400_B38","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1038\/nature25978","article-title":"Planning chemical syntheses with deep neural networks and symbolic AI","volume":"555","author":"MHS","year":"2018","journal-title":"Nature"},{"key":"2020062614040084400_B39","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1021\/acs.jcim.8b00801","article-title":"Enhancing retrosynthetic reaction prediction with deep learning using multiscale reaction classification","volume":"59","author":"Baylon","year":"2019","journal-title":"J. Chem. Inf. Model."},{"key":"2020062614040084400_B40","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1093\/bioinformatics\/bty838","article-title":"PrecursorFinder: a customized biosynthetic precursor explorer","volume":"35","author":"Yuan","year":"2018","journal-title":"Bioinformatics"},{"key":"2020062614040084400_B41","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1021\/acssynbio.9b00070","article-title":"CF-targeter: a rational biological cell factory targeting platform for biosynthetic target chemicals","volume":"8","author":"Ding","year":"2019","journal-title":"ACS Syntth. Biol."},{"key":"2020062614040084400_B42","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1021\/acschembio.7b00605","article-title":"EcoSynther: a customized platform to explore the biosynthetic potential in E. coli","volume":"12","author":"Ding","year":"2017","journal-title":"ACS Chem. Biol."},{"key":"2020062614040084400_B43","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1007\/s00425-017-2684-x","article-title":"Vanillin biosynthetic pathways in plants","volume":"245","author":"Kundu","year":"2017","journal-title":"Planta"},{"key":"2020062614040084400_B44","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/srep13670","article-title":"Mimicking a natural pathway for de novo biosynthesis: natural vanillin production from accessible carbon sources","volume":"5","author":"Ni","year":"2015","journal-title":"Sci. Rep"},{"key":"2020062614040084400_B45","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1038\/nchembio.2007.5","article-title":"The function of terpene natural products in the natural world","volume":"3","author":"Gershenzon","year":"2007","journal-title":"Nat. Chem. Biol."},{"key":"2020062614040084400_B46","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.ymben.2004.12.003","article-title":"Identifying gene targets for the metabolic engineering of lycopene biosynthesis in Escherichia coli","volume":"7","author":"Alper","year":"2005","journal-title":"Metab. Eng."},{"key":"2020062614040084400_B47","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1038\/nature04640","article-title":"Production of the antimalarial drug precursor artemisinic acid in engineered yeast","volume":"7086","author":"Ro","year":"2006","journal-title":"Nature"},{"key":"2020062614040084400_B48","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.pharmthera.2017.02.041","article-title":"Cannabidiol: State of the art and new challenges for therapeutic applications","volume":"175","author":"Pisanti","year":"2017","journal-title":"Pharmacol. Ther."},{"key":"2020062614040084400_B49","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/s41586-019-0978-9","article-title":"Complete biosynthesis of cannabinoids and their unnatural analogues in yeast","volume":"567","author":"Luo","year":"2019","journal-title":"Nature"}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/nar\/article-pdf\/48\/W1\/W477\/33433246\/gkaa230.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/nar\/article-pdf\/48\/W1\/W477\/33433246\/gkaa230.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T06:54:47Z","timestamp":1695970487000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article\/48\/W1\/W477\/5822956"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,20]]},"references-count":49,"journal-issue":{"issue":"W1","published-online":{"date-parts":[[2020,4,20]]},"published-print":{"date-parts":[[2020,7,2]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gkaa230","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,7,2]]},"published":{"date-parts":[[2020,4,20]]}}}