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Our web service provides a comprehensive collection of biological processes and signaling pathways for 12 model organisms that can be analyzed with a powerful framework for enrichment and network analysis of transcriptomic, miRNomic, proteomic,\u00a0and genomic data sets. Moreover, GeneTrail offers novel workflows for the analysis of epigenetic marks, time series experiments, and single cell data. We demonstrate the capabilities of our web service in two case-studies, which highlight that GeneTrail is well equipped for uncovering complex molecular mechanisms. GeneTrail is freely accessible at: http:\/\/genetrail.bioinf.uni-sb.de.<\/jats:p>","DOI":"10.1093\/nar\/gkaa306","type":"journal-article","created":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T11:11:42Z","timestamp":1587381102000},"page":"W515-W520","source":"Crossref","is-referenced-by-count":91,"title":["GeneTrail 3: advanced high-throughput enrichment analysis"],"prefix":"10.1093","volume":"48","author":[{"given":"Nico","family":"Gerstner","sequence":"first","affiliation":[{"name":"Center for Bioinformatics, Saarland Informatics Campus, Saarland University, 66123 Saarbr\u00fccken, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9523-7566","authenticated-orcid":false,"given":"Tim","family":"Kehl","sequence":"first","affiliation":[{"name":"Center for Bioinformatics, Saarland Informatics Campus, Saarland University, 66123 Saarbr\u00fccken, 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