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While there have been many efforts to develop computational tools to guide rational antibody engineering, most approaches are of limited accuracy when applied to antibody design, and have largely been limited to analysing a single point mutation at a time. To overcome this gap, we have curated a dataset of 242 experimentally determined changes in binding affinity upon multiple point mutations in antibody-target complexes (89 increasing and 153 decreasing binding affinity). Here, we have shown that by using our graph-based signatures and atomic interaction information, we can accurately analyse the consequence of multi-point mutations on antigen binding affinity. Our approach outperformed other available tools across cross-validation and two independent blind tests, achieving Pearson's correlations of up to 0.95. We have implemented our new approach, mmCSM-AB, as a web-server that can help guide the process of affinity maturation in antibody design. mmCSM-AB is freely available at http:\/\/biosig.unimelb.edu.au\/mmcsm_ab\/.<\/jats:p>","DOI":"10.1093\/nar\/gkaa389","type":"journal-article","created":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T11:17:34Z","timestamp":1589627854000},"page":"W125-W131","source":"Crossref","is-referenced-by-count":52,"title":["mmCSM-AB: guiding rational antibody engineering through multiple point mutations"],"prefix":"10.1093","volume":"48","author":[{"given":"Yoochan","family":"Myung","sequence":"first","affiliation":[{"name":"Computational Biology and Clinical Informatics, Baker Institute, Melbourne, VIC 3004, Australia"},{"name":"Structural Biology and Bioinformatics, Department of Biochemistry and Molecular Biology, Bio21 Institute, University of Melbourne, Parkville, VIC 3052, Australia"}]},{"given":"Douglas E V","family":"Pires","sequence":"first","affiliation":[{"name":"Computational Biology and Clinical Informatics, Baker Institute, Melbourne, VIC 3004, Australia"},{"name":"Structural Biology and Bioinformatics, Department of Biochemistry and Molecular Biology, Bio21 Institute, University of Melbourne, Parkville, VIC 3052, Australia"},{"name":"School of Computing and Information Systems, University of Melbourne, Parkville, VIC\u00a03052, Australia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2948-2413","authenticated-orcid":false,"given":"David B","family":"Ascher","sequence":"first","affiliation":[{"name":"Computational Biology and Clinical Informatics, Baker Institute, Melbourne, VIC 3004, Australia"},{"name":"Structural Biology and Bioinformatics, Department of Biochemistry and Molecular Biology, Bio21 Institute, University of Melbourne, Parkville, VIC 3052, Australia"},{"name":"Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK"}]}],"member":"286","published-online":{"date-parts":[[2020,5,20]]},"reference":[{"key":"2020062614042097200_B1","doi-asserted-by":"crossref","first-page":"3023","DOI":"10.1158\/1078-0432.CCR-08-2739","article-title":"Mutation-specific antibodies for the detection of EGFR mutations in non-small-cell lung cancer","volume":"15","author":"Yu","year":"2009","journal-title":"Clin. 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