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This tool, called Tox21BodyMap, incorporates results of 9,270 chemicals tested in the United States federal Tox21 research consortium in 971 high-throughput screening (HTS) assays whose targets were mapped onto human organs using organ-specific gene expression data. Via Tox21BodyMap's interactive tools, users can visualize chemical target specificity by organ system, and implement different filtering criteria by changing gene expression thresholds and activity concentration parameters. Dynamic network representations, data tables, and plots with comprehensive activity summaries across all Tox21 HTS assay targets provide an overall picture of chemical bioactivity. Tox21BodyMap webserver is available at https:\/\/sandbox.ntp.niehs.nih.gov\/bodymap\/.<\/jats:p>","DOI":"10.1093\/nar\/gkaa433","type":"journal-article","created":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T03:09:45Z","timestamp":1589252985000},"page":"W472-W476","source":"Crossref","is-referenced-by-count":6,"title":["Tox21BodyMap: a webtool to map chemical effects on the human body"],"prefix":"10.1093","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6499-4540","authenticated-orcid":false,"given":"Alexandre","family":"Borrel","sequence":"first","affiliation":[{"name":"NIH\/NIEHS\/DIR\/BCBB, RTP, NC 27709, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6294-3069","authenticated-orcid":false,"given":"Scott S","family":"Auerbach","sequence":"first","affiliation":[{"name":"NIH\/NIEHS\/DNTP\/BSB, RTP, NC 27709, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith A","family":"Houck","sequence":"first","affiliation":[{"name":"EPA\/ORD\/CCTE, RTP, NC 27709, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7914-3682","authenticated-orcid":false,"given":"Nicole C","family":"Kleinstreuer","sequence":"first","affiliation":[{"name":"NIH\/NIEHS\/DIR\/BCBB, RTP, NC 27709, USA"},{"name":"NIH\/NIEHS\/DNTP\/NICEATM, RTP, NC 27709, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,6,3]]},"reference":[{"key":"2020062614051483700_B1","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1126\/science.1154619","article-title":"Transforming environmental health protection","volume":"319","author":"Collins","year":"2008","journal-title":"Science"},{"key":"2020062614051483700_B2","doi-asserted-by":"crossref","first-page":"163","DOI":"10.14573\/altex.1803011","article-title":"The US Federal Tox21 Program: a strategic and operational plan for continued leadership","volume":"35","author":"Thomas","year":"2018","journal-title":"ALTEX"},{"key":"2020062614051483700_B3","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/nbt.2914","article-title":"Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanisms","volume":"32","author":"Kleinstreuer","year":"2014","journal-title":"Nat. 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Health Perspect."}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/nar\/article-pdf\/48\/W1\/W472\/33433475\/gkaa433.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/nar\/article-pdf\/48\/W1\/W472\/33433475\/gkaa433.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,27]],"date-time":"2020-06-27T06:48:01Z","timestamp":1593240481000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article\/48\/W1\/W472\/5850804"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,3]]},"references-count":13,"journal-issue":{"issue":"W1","published-online":{"date-parts":[[2020,6,3]]},"published-print":{"date-parts":[[2020,7,2]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gkaa433","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,7,2]]},"published":{"date-parts":[[2020,6,3]]}}}