{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:41:19Z","timestamp":1772138479714,"version":"3.50.1"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T00:00:00Z","timestamp":1597708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","award":["RR170055"],"award-info":[{"award-number":["RR170055"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","award":["RP160716"],"award-info":[{"award-number":["RP160716"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["UO1CA199297"],"award-info":[{"award-number":["UO1CA199297"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Greehey Children\u2019s Cancer Research Institute"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Although cancer is the leading cause of disease-related mortality in children, the relative rarity of pediatric cancers poses a significant challenge for developing novel therapeutics to further improve prognosis. Patient-derived xenograft (PDX) models, which are usually developed from high-risk tumors, are a useful platform to study molecular driver events, identify biomarkers and prioritize therapeutic agents. Here, we develop PDX for Childhood Cancer Therapeutics (PCAT), a new integrated portal for pediatric cancer PDX models. Distinct from previously reported PDX portals, PCAT is focused on pediatric cancer models and provides intuitive interfaces for querying and data mining. The current release comprises 324 models and their associated clinical and genomic data, including gene expression, mutation and copy number alteration. Importantly, PCAT curates preclinical testing results for 68 models and 79 therapeutic agents manually collected from individual agent testing studies published since 2008. To facilitate comparisons of patterns between patient tumors and PDX models, PCAT curates clinical and molecular data of patient tumors from the TARGET project. In addition, PCAT provides access to gene fusions identified in nearly 1000 TARGET samples. PCAT was built using R-shiny and MySQL. The portal can be accessed at http:\/\/pcat.zhenglab.info or http:\/\/www.pedtranscriptome.org.<\/jats:p>","DOI":"10.1093\/nar\/gkaa698","type":"journal-article","created":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T15:31:37Z","timestamp":1597159897000},"page":"D1321-D1327","source":"Crossref","is-referenced-by-count":16,"title":["PCAT: an integrated portal for genomic and preclinical testing data of pediatric cancer patient-derived xenograft models"],"prefix":"10.1093","volume":"49","author":[{"given":"Juechen","family":"Yang","sequence":"first","affiliation":[{"name":"Greehey Children\u2019s Cancer Research Institute, University of Texas Health at San Antonio, San Antonio, TX 78229, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qilin","family":"Li","sequence":"additional","affiliation":[{"name":"Greehey Children\u2019s Cancer Research Institute, University of Texas Health at San Antonio, San Antonio, TX 78229, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nighat","family":"Noureen","sequence":"additional","affiliation":[{"name":"Greehey Children\u2019s Cancer Research Institute, University of Texas Health at San Antonio, San Antonio, TX 78229, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanbing","family":"Fang","sequence":"additional","affiliation":[{"name":"Greehey Children\u2019s Cancer Research Institute, University of Texas Health at San Antonio, San Antonio, TX 78229, USA"},{"name":"School of Natural Science, University of Texas at Austin, Austin, TX 78712, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raushan","family":"Kurmasheva","sequence":"additional","affiliation":[{"name":"Greehey Children\u2019s Cancer Research Institute, University of Texas Health at San Antonio, San Antonio, TX 78229, USA"},{"name":"Department of Molecular Medicine, University of Texas Health at San Antonio, San Antonio, TX 78229, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J","family":"Houghton","sequence":"additional","affiliation":[{"name":"Greehey Children\u2019s Cancer Research Institute, University of Texas Health at San Antonio, San Antonio, TX 78229, USA"},{"name":"Department of Molecular Medicine, University of Texas Health at San Antonio, San Antonio, TX 78229, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojing","family":"Wang","sequence":"additional","affiliation":[{"name":"Greehey Children\u2019s Cancer Research Institute, University of Texas Health at San Antonio, San Antonio, TX 78229, USA"},{"name":"Department of Population Health Sciences, University of Texas Health at San Antonio, San Antonio, TX 78229,\u00a0USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siyuan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Greehey Children\u2019s Cancer Research Institute, University of Texas Health at San Antonio, San Antonio, TX 78229, USA"},{"name":"Department of Population Health Sciences, University of Texas Health at San Antonio, San Antonio, TX 78229,\u00a0USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,8,18]]},"reference":[{"key":"2021010313110241500_B1","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1126\/science.aaw3535","article-title":"The genomic landscape of pediatric cancers: implications for diagnosis and treatment","volume":"363","author":"Sweet-Cordero","year":"2019","journal-title":"Science"},{"key":"2021010313110241500_B2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21551","article-title":"Cancer statistics, 2019","volume":"69","author":"Siegel","year":"2019","journal-title":"CA Cancer J. Clin."},{"key":"2021010313110241500_B3","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1124\/pr.118.016972","article-title":"Challenges and opportunities for childhood cancer drug development","volume":"71","author":"Houghton","year":"2019","journal-title":"Pharmacol. Rev."},{"key":"2021010313110241500_B4","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1158\/2159-8290.CD-14-0001","article-title":"Patient-derived xenograft models: an emerging platform for translational cancer research","volume":"4","author":"Hidalgo","year":"2014","journal-title":"Cancer Discov."},{"key":"2021010313110241500_B5","first-page":"437","article-title":"Growth and characterization of childhood rhabdomyosarcomas as xenografts","volume":"68","author":"Houghton","year":"1982","journal-title":"J. Natl. 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