{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T22:39:56Z","timestamp":1775083196323,"version":"3.50.1"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T00:00:00Z","timestamp":1601251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key Technology R&D Program","award":["2019YFC1708902"],"award-info":[{"award-number":["2019YFC1708902"]}]},{"name":"National Major Scientific and Technological Special Project","award":["2018ZX09735001-003"],"award-info":[{"award-number":["2018ZX09735001-003"]}]},{"name":"National Major Scientific and Technological Special Project","award":["2019ZX09201005-001-002"],"award-info":[{"award-number":["2019ZX09201005-001-002"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Marine organisms are expected to be an important source of inspiration for drug discovery after terrestrial plants and microorganisms. Despite the remarkable progress in the field of marine natural products (MNPs) chemistry, there are only a few open access databases dedicated to MNPs research. To meet the growing demand for mining and sharing for MNPs-related data resources, we developed CMNPD, a comprehensive marine natural products database based on manually curated data. CMNPD currently contains more than 31 000 chemical entities with various physicochemical and pharmacokinetic properties, standardized biological activity data, systematic taxonomy and geographical distribution of source organisms, and detailed literature citations. It is an integrated platform for structure dereplication (assessment of novelty) of (marine) natural products, discovery of lead compounds, data mining of structure-activity relationships and investigation of chemical ecology. Access is available through a user-friendly web interface at https:\/\/www.cmnpd.org. We are committed to providing a free data sharing platform for not only professional MNPs researchers but also the broader scientific community to facilitate drug discovery from the ocean.<\/jats:p>","DOI":"10.1093\/nar\/gkaa763","type":"journal-article","created":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T11:10:11Z","timestamp":1599131411000},"page":"D509-D515","source":"Crossref","is-referenced-by-count":223,"title":["CMNPD: a comprehensive marine natural products database towards facilitating drug discovery from the ocean"],"prefix":"10.1093","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2871-9407","authenticated-orcid":false,"given":"Chuanyu","family":"Lyu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China"}]},{"given":"Tong","family":"Chen","sequence":"additional","affiliation":[{"name":"National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China"}]},{"given":"Bo","family":"Qiang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China"}]},{"given":"Ningfeng","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China"}]},{"given":"Heyu","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7362-9497","authenticated-orcid":false,"given":"Liangren","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8993-4015","authenticated-orcid":false,"given":"Zhenming","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China"}]}],"member":"286","published-online":{"date-parts":[[2020,9,28]]},"reference":[{"key":"2021010313111028500_B1","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1021\/acs.jnatprod.9b01285","article-title":"Natural products as sources of new drugs over the nearly four decades from 01\/1981 to 09\/2019","volume":"83","author":"Newman","year":"2020","journal-title":"J. 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