{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T19:32:41Z","timestamp":1782761561304,"version":"3.54.5"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T00:00:00Z","timestamp":1600992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Federal Ministry of Education and Research","doi-asserted-by":"publisher","award":["01ZX1908A"],"award-info":[{"award-number":["01ZX1908A"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"name":"VILLUM Young Investor","award":["13154"],"award-info":[{"award-number":["13154"]}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020","doi-asserted-by":"publisher","award":["777111"],"award-info":[{"award-number":["777111"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Alternative splicing plays a major role in regulating the functional repertoire of the proteome. However, isoform-specific effects to protein-protein interactions (PPIs) are usually overlooked, making it impossible to judge the functional role of individual exons on a systems biology level. We overcome this barrier by integrating protein-protein interactions, domain-domain interactions and residue-level interactions information to lift exon expression analysis to a network level. Our user-friendly database DIGGER is available at https:\/\/exbio.wzw.tum.de\/digger and allows users to seamlessly switch between isoform and exon-centric views of the interactome and to extract sub-networks of relevant isoforms, making it an essential resource for studying mechanistic consequences of alternative splicing.<\/jats:p>","DOI":"10.1093\/nar\/gkaa768","type":"journal-article","created":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T19:14:34Z","timestamp":1599246874000},"page":"D309-D318","source":"Crossref","is-referenced-by-count":61,"title":["DIGGER: exploring the functional role of alternative splicing in protein interactions"],"prefix":"10.1093","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4763-0264","authenticated-orcid":false,"given":"Zakaria","family":"Louadi","sequence":"first","affiliation":[{"name":"Chair of Experimental Bioinformatics, TUM School of Life Sciences Weihenstephan,\u00a0Technical University of Munich, 85354 Freising, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1283-2712","authenticated-orcid":false,"given":"Kevin","family":"Yuan","sequence":"additional","affiliation":[{"name":"Chair of Experimental Bioinformatics, TUM School of Life Sciences Weihenstephan,\u00a0Technical University of Munich, 85354 Freising, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Gress","sequence":"additional","affiliation":[{"name":"Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), 66123 Saarbr\u00fccken, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Tsoy","sequence":"additional","affiliation":[{"name":"Chair of Experimental Bioinformatics, TUM School of Life Sciences Weihenstephan,\u00a0Technical University of Munich, 85354 Freising, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9445-477X","authenticated-orcid":false,"given":"Olga V","family":"Kalinina","sequence":"additional","affiliation":[{"name":"Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), 66123 Saarbr\u00fccken, Germany"},{"name":"Faculty of Medicine, Saarland University, 66421 Homburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Baumbach","sequence":"additional","affiliation":[{"name":"Chair of Experimental Bioinformatics, TUM School of Life Sciences Weihenstephan,\u00a0Technical University of Munich, 85354 Freising, Germany"},{"name":"Department of Mathematics and Computer Science, University of Southern Denmark, 5230 Odense M, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5393-2413","authenticated-orcid":false,"given":"Tim","family":"Kacprowski","sequence":"additional","affiliation":[{"name":"Chair of Experimental Bioinformatics, TUM School of Life Sciences Weihenstephan,\u00a0Technical University of Munich, 85354 Freising, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0941-4168","authenticated-orcid":false,"given":"Markus","family":"List","sequence":"additional","affiliation":[{"name":"Chair of Experimental Bioinformatics, TUM School of Life Sciences Weihenstephan,\u00a0Technical University of Munich, 85354 Freising, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,9,25]]},"reference":[{"key":"2021010313120795700_B1","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.cell.2016.01.029","article-title":"Widespread expansion of protein interaction capabilities by alternative splicing","volume":"164","author":"Yang","year":"2016","journal-title":"Cell"},{"key":"2021010313120795700_B2","doi-asserted-by":"crossref","first-page":"R74","DOI":"10.1186\/gb-2004-5-10-r74","article-title":"Variation in alternative splicing across human tissues","volume":"5","author":"Yeo","year":"2004","journal-title":"Genome Biol."},{"key":"2021010313120795700_B3","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1101\/gad.1973010","article-title":"Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged","volume":"24","author":"David","year":"2010","journal-title":"Genes Dev."},{"key":"2021010313120795700_B4","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1007\/s12551-018-0439-y","article-title":"Alternative splicing in cardiomyopathy","volume":"10","author":"Beqqali","year":"2018","journal-title":"Biophys. 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