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To fight the novel coronavirus, one of the best-known ways is to block enzymes essential for virus replication. Currently, we know that the SARS-CoV-2 virus encodes about 29 proteins such as spike protein, 3C-like protease (3CLpro), RNA-dependent RNA polymerase (RdRp), Papain-like protease (PLpro), and nucleocapsid (N) protein. SARS-CoV-2 uses human angiotensin-converting enzyme 2 (ACE2) for viral entry and transmembrane serine protease family member II (TMPRSS2) for spike protein priming. Thus in order to speed up the discovery of potential drugs, we develop DockCoV2, a drug database for SARS-CoV-2. DockCoV2 focuses on predicting the binding affinity of FDA-approved and Taiwan National Health Insurance (NHI) drugs with the seven proteins mentioned above. This database contains a total of 3,109 drugs. DockCoV2 is easy to use and search against, is well cross-linked to external databases, and provides the state-of-the-art prediction results in one site. Users can download their drug-protein docking data of interest and examine additional drug-related information on DockCoV2. Furthermore, DockCoV2 provides experimental information to help users understand which drugs have already been reported to be effective against MERS or SARS-CoV. DockCoV2 is available at https:\/\/covirus.cc\/drugs\/.<\/jats:p>","DOI":"10.1093\/nar\/gkaa861","type":"journal-article","created":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T11:47:27Z","timestamp":1600861647000},"page":"D1152-D1159","source":"Crossref","is-referenced-by-count":54,"title":["DockCoV2: a drug database against SARS-CoV-2"],"prefix":"10.1093","volume":"49","author":[{"given":"Ting-Fu","family":"Chen","sequence":"first","affiliation":[{"name":"Taiwan AI Labs, Taipei 10351, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Chuan","family":"Chang","sequence":"additional","affiliation":[{"name":"Taiwan AI Labs, Taipei 10351, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Hsiao","sequence":"additional","affiliation":[{"name":"Taiwan AI Labs, Taipei 10351, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ko-Han","family":"Lee","sequence":"additional","affiliation":[{"name":"Taiwan AI Labs, Taipei 10351, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Chun","family":"Hsiao","sequence":"additional","affiliation":[{"name":"Taiwan AI Labs, Taipei 10351, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Hsiang","family":"Lin","sequence":"additional","affiliation":[{"name":"Taiwan AI Labs, Taipei 10351, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Chin Ethan","family":"Tu","sequence":"additional","affiliation":[{"name":"Taiwan AI Labs, Taipei 10351, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3386-0934","authenticated-orcid":false,"given":"Hsuan-Cheng","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Informatics, National Yang-Ming University, Taipei 11221, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chien-Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Taiwan AI Labs, Taipei 10351, Taiwan"},{"name":"Department of Biomechatronics Engineering, National Taiwan University, Taipei 10617, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4876-3309","authenticated-orcid":false,"given":"Hsueh-Fen","family":"Juan","sequence":"additional","affiliation":[{"name":"Taiwan AI Labs, Taipei 10351, Taiwan"},{"name":"Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei 10617, Taiwan"},{"name":"Department of Life Science, National Taiwan University, Taipei 10617, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,10,9]]},"reference":[{"key":"2021010313125053300_B1","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S1473-3099(20)30120-1","article-title":"An interactive web-based dashboard to track COVID-19 in real time","volume":"20","author":"Dong","year":"2020","journal-title":"Lancet Infect. 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