{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T03:13:40Z","timestamp":1778210020381,"version":"3.51.4"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2020,10,17]],"date-time":"2020-10-17T00:00:00Z","timestamp":1602892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2016YFA0502204"],"award-info":[{"award-number":["2016YFA0502204"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFA0504304"],"award-info":[{"award-number":["2017YFA0504304"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772960"],"award-info":[{"award-number":["81772960"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81902819"],"award-info":[{"award-number":["81902819"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology Program of Sichuan Province","award":["2019JDTD0013"],"award-info":[{"award-number":["2019JDTD0013"]}]},{"name":"Science and Technology Program of Sichuan Province","award":["2020YFS0222"],"award-info":[{"award-number":["2020YFS0222"]}]},{"DOI":"10.13039\/501100004912","name":"Sichuan University","doi-asserted-by":"publisher","award":["ZYJC18030"],"award-info":[{"award-number":["ZYJC18030"]}],"id":[{"id":"10.13039\/501100004912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004912","name":"Sichuan University","doi-asserted-by":"publisher","award":["ZYGD20008"],"award-info":[{"award-number":["ZYGD20008"]}],"id":[{"id":"10.13039\/501100004912","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>tRNA-derived small RNAs (tsRNAs) are a class of novel small RNAs, ubiquitously present in prokaryotes and eukaryotes. It has been reported that tsRNAs exhibit spatiotemporal expression patterns and can function as regulatory molecules in many biological processes. Current tsRNA databases only cover limited organisms and ignore tsRNA functional characteristics. Thus, integrating more relevant tsRNA information is helpful for further exploration. Here, we present a tsRNA database, named tsRBase, which integrates the expression pattern and functional information of tsRNAs in multiple species. In tsRBase, we identified 121 942 tsRNAs by analyzing more than 14 000 publicly available small RNA-seq data covering 20 species. This database collects samples from different tissues\/cell-lines, or under different treatments and genetic backgrounds, thus helps depict specific expression patterns of tsRNAs under different conditions. Importantly, to enrich our understanding of biological significance, we collected tsRNAs experimentally validated from published literatures, obtained protein-binding tsRNAs from CLIP\/RIP-seq data, and identified targets of tsRNAs from CLASH and CLEAR-CLIP data. Taken together, tsRBase is the most comprehensive and systematic tsRNA repository, exhibiting all-inclusive information of tsRNAs from diverse data sources of multiple species. tsRBase is freely available at http:\/\/www.tsrbase.org.<\/jats:p>","DOI":"10.1093\/nar\/gkaa888","type":"journal-article","created":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T21:19:34Z","timestamp":1601414374000},"page":"D1038-D1045","source":"Crossref","is-referenced-by-count":57,"title":["tsRBase: a comprehensive database for expression and function of tsRNAs in multiple species"],"prefix":"10.1093","volume":"49","author":[{"given":"Yuanli","family":"Zuo","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Oncology, Frontiers Science Center for Disease-related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu\u00a0610064, China"},{"name":"Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of life Sciences, Sichuan University, Chengdu 610041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Oncology, Frontiers Science Center for Disease-related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu\u00a0610064, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhixin","family":"Guo","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Oncology, Frontiers Science Center for Disease-related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu\u00a0610064, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenrong","family":"Liu","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Oncology, Frontiers Science Center for Disease-related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu\u00a0610064, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiting","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of life Sciences, Sichuan University, Chengdu 610041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Zeng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of life Sciences, Sichuan University, Chengdu 610041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingbin","family":"Wu","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Oncology, Frontiers Science Center for Disease-related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu\u00a0610064, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Cheng","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Oncology, Frontiers Science Center for Disease-related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu\u00a0610064, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Fu","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Oncology, Frontiers Science Center for Disease-related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu\u00a0610064, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Jin","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Oncology, Frontiers Science Center for Disease-related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu\u00a0610064, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Zhao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of life Sciences, Sichuan University, Chengdu 610041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1181-3467","authenticated-orcid":false,"given":"Yong","family":"Peng","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Oncology, Frontiers Science Center for Disease-related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu\u00a0610064, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,10,17]]},"reference":[{"key":"2021010313113041000_B1","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1002\/1097-0142(197912)44:6<2120::AID-CNCR2820440623>3.0.CO;2-6","article-title":"tRNA breakdown products as markers for cancer","volume":"44","author":"John\u00a0Speer","year":"1979","journal-title":"Cancer"},{"key":"2021010313113041000_B2","doi-asserted-by":"crossref","first-page":"42744","DOI":"10.1074\/jbc.M510356200","article-title":"Starvation-induced cleavage of the tRNA anticodon loop in Tetrahymena thermophila","volume":"280","author":"Lee","year":"2005","journal-title":"J. Biol. Chem."},{"key":"2021010313113041000_B3","doi-asserted-by":"crossref","first-page":"6048","DOI":"10.1093\/nar\/gkn596","article-title":"Stress-induced tRNA-derived RNAs: a novel class of small RNAs in the primitive eukaryote Giardia lamblia","volume":"36","author":"Li","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"2021010313113041000_B4","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.tibs.2016.05.004","article-title":"Biogenesis and function of transfer RNA-related fragments (tRFs)","volume":"41","author":"Kumar","year":"2016","journal-title":"Trends Biochem. Sci."},{"key":"2021010313113041000_B5","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s12915-014-0078-0","article-title":"Meta-analysis of tRNA derived RNA fragments reveals that they are evolutionarily conserved and associate with AGO proteins to recognize specific RNA targets","volume":"12","author":"Kumar","year":"2014","journal-title":"BMC Biol."},{"key":"2021010313113041000_B6","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s11427-017-9167-5","article-title":"Transfer RNA-derived small RNAs in plants","volume":"61","author":"Zhu","year":"2018","journal-title":"Sci. China Life Sci."},{"key":"2021010313113041000_B7","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1083\/jcb.200811119","article-title":"The RNase Rny1p cleaves tRNAs and promotes cell death during oxidative stress in Saccharomyces cerevisiae","volume":"185","author":"Thompson","year":"2009","journal-title":"J. Cell Biol."},{"key":"2021010313113041000_B8","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.4161\/rna.27177","article-title":"Slicing tRNAs to boost functional ncRNA diversity","volume":"10","author":"Gebetsberger","year":"2013","journal-title":"RNA Biol."},{"key":"2021010313113041000_B9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.canlet.2018.01.015","article-title":"tRNA-derived small non-coding RNAs in human disease","volume":"419","author":"Zhu","year":"2018","journal-title":"Cancer Lett."},{"key":"2021010313113041000_B10","doi-asserted-by":"crossref","first-page":"8071","DOI":"10.1073\/pnas.1706908114","article-title":"tsRNA signatures in cancer","volume":"114","author":"Balatti","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021010313113041000_B11","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1101\/gad.1837609","article-title":"A novel class of small RNAs: tRNA-derived RNA fragments (tRFs)","volume":"23","author":"Lee","year":"2009","journal-title":"Genes Dev."},{"key":"2021010313113041000_B12","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.febslet.2008.12.043","article-title":"Stress induces tRNA cleavage by angiogenin in mammalian cells","volume":"583","author":"Fu","year":"2009","journal-title":"FEBS Lett."},{"key":"2021010313113041000_B13","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1083\/jcb.200811106","article-title":"Angiogenin cleaves tRNA and promotes stress-induced translational repression","volume":"185","author":"Yamasaki","year":"2009","journal-title":"J. Cell Biol."},{"key":"2021010313113041000_B14","doi-asserted-by":"crossref","first-page":"14159","DOI":"10.1073\/pnas.1414394111","article-title":"Both endo-siRNAs and tRNA-derived small RNAs are involved in the differentiation of primitive eukaryote Giardia lamblia","volume":"111","author":"Liao","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021010313113041000_B15","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/s41467-018-07949-6","article-title":"A tRNA half modulates translation as stress response in Trypanosoma brucei","volume":"10","author":"Fricker","year":"2019","journal-title":"Nat. Commun."},{"key":"2021010313113041000_B16","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1126\/science.aad6780","article-title":"Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals","volume":"351","author":"Sharma","year":"2016","journal-title":"Science"},{"key":"2021010313113041000_B17","doi-asserted-by":"crossref","first-page":"5071","DOI":"10.1073\/pnas.1604266113","article-title":"Dysregulation of a family of short noncoding RNAs, tsRNAs, in human cancer","volume":"113","author":"Pekarsky","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021010313113041000_B18","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s12943-019-1000-8","article-title":"Exosomal tRNA-derived small RNA as a promising biomarker for cancer diagnosis","volume":"18","author":"Zhu","year":"2019","journal-title":"Mol. Cancer"},{"key":"2021010313113041000_B19","doi-asserted-by":"crossref","first-page":"24252","DOI":"10.1073\/pnas.1913695116","article-title":"Dysregulation of different classes of tRNA fragments in chronic lymphocytic leukemia","volume":"116","author":"Veneziano","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021010313113041000_B20","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.canlet.2017.10.031","article-title":"Roles of tRNA-derived fragments in human cancers","volume":"414","author":"Sun","year":"2018","journal-title":"Cancer Lett."},{"key":"2021010313113041000_B21","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3389\/fgene.2014.00171","article-title":"tRNAs as regulators of biological processes","volume":"5","author":"Raina","year":"2014","journal-title":"Front. Genet."},{"key":"2021010313113041000_B22","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature25005","article-title":"A transfer-RNA-derived small RNA regulates ribosome biogenesis","volume":"552","author":"Kim","year":"2017","journal-title":"Nature"},{"key":"2021010313113041000_B23","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.cell.2017.06.013","article-title":"LTR-retrotransposon control by tRNA-derived small RNAs","volume":"170","author":"Schorn","year":"2017","journal-title":"Cell"},{"key":"2021010313113041000_B24","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1126\/science.aad7977","article-title":"Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder","volume":"351","author":"Chen","year":"2016","journal-title":"Science"},{"key":"2021010313113041000_B25","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.canlet.2019.05.007","article-title":"A tRNA fragment, 5\u2032-tiRNA, suppresses the Wnt\/\u03b2-catenin signaling pathway by targeting FZD3 in breast cancer","volume":"457","author":"Mo","year":"2019","journal-title":"Cancer Lett."},{"key":"2021010313113041000_B26","doi-asserted-by":"crossref","first-page":"5142","DOI":"10.1093\/nar\/gkx103","article-title":"tRNA-derived small RNAs target transposable element transcripts","volume":"45","author":"German","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"2021010313113041000_B27","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.canlet.2019.03.012","article-title":"tRNA-derived fragments and tRNA halves: the new players in cancers","volume":"452","author":"Zhu","year":"2019","journal-title":"Cancer Lett."},{"key":"2021010313113041000_B28","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1261\/rna.066126.118","article-title":"tRNA fragments (tRFs) guide Ago to regulate gene expression post-transcriptionally in a Dicer-independent manner","volume":"24","author":"Kuscu","year":"2018","journal-title":"RNA"},{"key":"2021010313113041000_B29","doi-asserted-by":"crossref","first-page":"8984","DOI":"10.1093\/nar\/gku620","article-title":"The human Piwi protein Hiwi2 associates with tRNA-derived piRNAs in somatic cells","volume":"42","author":"Keam","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"2021010313113041000_B30","doi-asserted-by":"crossref","first-page":"D141","DOI":"10.1093\/nar\/gku1138","article-title":"tRFdb: a database for transfer RNA fragments","volume":"43","author":"Kumar","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"2021010313113041000_B31","doi-asserted-by":"crossref","first-page":"bay063","DOI":"10.1093\/database\/bay063","article-title":"PtRFdb: a database for plant transfer RNA-derived fragments","volume":"2018","author":"Gupta","year":"2018","journal-title":"Database (Oxford)"},{"key":"2021010313113041000_B32","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1093\/pcp\/pcx173","article-title":"tRex: a web portal for exploration of tRNA-derived fragments in Arabidopsis thaliana","volume":"59","author":"Thompson","year":"2018","journal-title":"Plant Cell Physiol."},{"key":"2021010313113041000_B33","doi-asserted-by":"crossref","first-page":"D152","DOI":"10.1093\/nar\/gkx1075","article-title":"MINTbase v2.0: a comprehensive database for tRNA-derived fragments that includes nuclear and mitochondrial fragments from all The Cancer Genome Atlas projects","volume":"46","author":"Pliatsika","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"2021010313113041000_B34","doi-asserted-by":"crossref","first-page":"W185","DOI":"10.1093\/nar\/gkw414","article-title":"tRF2Cancer: A web server to detect tRNA-derived small RNA fragments (tRFs) and their expression in multiple cancers","volume":"44","author":"Zheng","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"2021010313113041000_B35","doi-asserted-by":"crossref","first-page":"baz115","DOI":"10.1093\/database\/baz115","article-title":"Identification of tRNA-derived ncRNAs in TCGA and NCI-60 panel cell lines and development of the public database tRFexplorer","volume":"2019","author":"La\u00a0Ferlita","year":"2019","journal-title":"Database (Oxford)"},{"key":"2021010313113041000_B36","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1080\/15476286.2020.1776506","article-title":"OncotRF: an online resource for exploration of tRNA-derived fragments in human cancers","volume":"17","author":"Yao","year":"2020","journal-title":"RNA Biol."},{"key":"2021010313113041000_B37","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.cell.2013.03.043","article-title":"Mapping the human miRNA interactome by CLASH reveals frequent noncanonical binding","volume":"153","author":"Helwak","year":"2013","journal-title":"Cell"},{"key":"2021010313113041000_B38","doi-asserted-by":"crossref","first-page":"8864","DOI":"10.1038\/ncomms9864","article-title":"miRNA-target chimeras reveal miRNA 3\u2032-end pairing as a major determinant of Argonaute target specificity","volume":"6","author":"Moore","year":"2015","journal-title":"Nat. Commun."},{"key":"2021010313113041000_B39","doi-asserted-by":"crossref","first-page":"D19","DOI":"10.1093\/nar\/gkq1019","article-title":"The sequence read archive","volume":"39","author":"Leinonen","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"2021010313113041000_B40","doi-asserted-by":"crossref","first-page":"10","DOI":"10.14806\/ej.17.1.200","article-title":"Cutadapt removes adapter sequences from high-throughput sequencing reads","volume":"17","author":"Martin","year":"2011","journal-title":"EMBnet.journal"},{"key":"2021010313113041000_B41","doi-asserted-by":"crossref","first-page":"D184","DOI":"10.1093\/nar\/gkv1309","article-title":"GtRNAdb 2.0: an expanded database of transfer RNA genes identified in complete and draft genomes","volume":"44","author":"Chan","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"2021010313113041000_B42","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","article-title":"Basic local alignment search tool","volume":"215","author":"Altschul","year":"1990","journal-title":"J. Mol. Biol."},{"key":"2021010313113041000_B43","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.molcel.2016.05.026","article-title":"The lupus autoantigen La prevents Mis-channeling of tRNA fragments into the human MicroRNA pathway","volume":"63","author":"Hasler","year":"2016","journal-title":"Mol. Cell"},{"key":"2021010313113041000_B44","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1073\/pnas.1206761110","article-title":"tRNA-derived microRNA modulates proliferation and the DNA damage response and is down-regulated in B cell lymphoma","volume":"110","author":"Maute","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021010313113041000_B45","doi-asserted-by":"crossref","first-page":"W451","DOI":"10.1093\/nar\/gkl243","article-title":"RNAhybrid: microRNA target prediction easy, fast and flexible","volume":"34","author":"Kruger","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"2021010313113041000_B46","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1093\/bioinformatics\/btq033","article-title":"BEDTools: a flexible suite of utilities for comparing genomic features","volume":"26","author":"Quinlan","year":"2010","journal-title":"Bioinformatics"},{"key":"2021010313113041000_B47","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1093\/bioinformatics\/btm331","article-title":"ViroBLAST: a stand-alone BLAST web server for flexible queries of multiple databases and user's datasets","volume":"23","author":"Deng","year":"2007","journal-title":"Bioinformatics"}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/nar\/article-pdf\/49\/D1\/D1038\/35364580\/gkaa888.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/nar\/article-pdf\/49\/D1\/D1038\/35364580\/gkaa888.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,3]],"date-time":"2021-01-03T18:12:47Z","timestamp":1609697567000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article\/49\/D1\/D1038\/5929244"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,17]]},"references-count":47,"journal-issue":{"issue":"D1","published-online":{"date-parts":[[2020,10,17]]},"published-print":{"date-parts":[[2021,1,8]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gkaa888","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,1,8]]},"published":{"date-parts":[[2020,10,17]]}}}