{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:37:44Z","timestamp":1777423064475,"version":"3.51.4"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2020,10,26]],"date-time":"2020-10-26T00:00:00Z","timestamp":1603670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HD062499"],"award-info":[{"award-number":["HD062499"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The Gene Expression Database (GXD; www.informatics.jax.org\/expression.shtml) is an extensive and well-curated community resource of mouse developmental gene expression information. For many years, GXD has collected and integrated data from RNA in situ hybridization, immunohistochemistry, RT-PCR, northern blot, and western blot experiments through curation of the scientific literature and by collaborations with large-scale expression projects. Since our last report in 2019, we have continued to acquire these classical types of expression data; developed a searchable index of RNA-Seq and microarray experiments that allows users to quickly and reliably find specific mouse expression studies in ArrayExpress (https:\/\/www.ebi.ac.uk\/arrayexpress\/) and GEO (https:\/\/www.ncbi.nlm.nih.gov\/geo\/); and expanded GXD to include RNA-Seq data. Uniformly processed RNA-Seq data are imported from the EBI Expression Atlas and then integrated with the other types of expression data in GXD, and with the genetic, functional, phenotypic and disease-related information in Mouse Genome Informatics (MGI). This integration has made the RNA-Seq data accessible via GXD\u2019s enhanced searching and filtering capabilities. Further, we have embedded the Morpheus heat map utility into the GXD user interface to provide additional tools for display and analysis of RNA-Seq data, including heat map visualization, sorting, filtering, hierarchical clustering, nearest neighbors analysis and visual enrichment.<\/jats:p>","DOI":"10.1093\/nar\/gkaa914","type":"journal-article","created":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T04:28:31Z","timestamp":1601699311000},"page":"D924-D931","source":"Crossref","is-referenced-by-count":133,"title":["The mouse Gene Expression Database (GXD): 2021 update"],"prefix":"10.1093","volume":"49","author":[{"given":"Richard M","family":"Baldarelli","sequence":"first","affiliation":[{"name":"The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA"}]},{"given":"Constance M","family":"Smith","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA"}]},{"given":"Jacqueline H","family":"Finger","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA"}]},{"given":"Terry F","family":"Hayamizu","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA"}]},{"given":"Ingeborg J","family":"McCright","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA"}]},{"given":"Jingxia","family":"Xu","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA"}]},{"given":"David R","family":"Shaw","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA"}]},{"given":"Jonathan S","family":"Beal","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA"}]},{"given":"Olin","family":"Blodgett","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA"}]},{"given":"Jeffrey","family":"Campbell","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA"}]},{"given":"Lori E","family":"Corbani","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA"}]},{"given":"Pete J","family":"Frost","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA"}]},{"given":"Sharon C","family":"Giannatto","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA"}]},{"given":"Dave B","family":"Miers","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA"}]},{"given":"James\u00a0A","family":"Kadin","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA"}]},{"given":"Joel E","family":"Richardson","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5696-5421","authenticated-orcid":false,"given":"Martin","family":"Ringwald","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA"}]}],"member":"286","published-online":{"date-parts":[[2020,10,26]]},"reference":[{"key":"2021010313125512200_B1","doi-asserted-by":"crossref","first-page":"D801","DOI":"10.1093\/nar\/gky1056","article-title":"Mouse Genome Database (MGD) 2019","volume":"47","author":"Bult","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"2021010313125512200_B2","doi-asserted-by":"crossref","first-page":"D774","DOI":"10.1093\/nar\/gky922","article-title":"The mouse Gene Expression Database (GXD): 2019 update","volume":"47","author":"Smith","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"2021010313125512200_B3","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1007\/s00335-015-9580-0","article-title":"Application of comparative biology in GO functional annotation: the mouse model","volume":"9","author":"Drabkin","year":"2015","journal-title":"Mamm. 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