{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T01:49:59Z","timestamp":1776044999504,"version":"3.50.1"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T00:00:00Z","timestamp":1603411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01CA218668"],"award-info":[{"award-number":["R01CA218668"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Most mutations in cancer genomes occur in the non-coding regions with unknown impact on tumor development. Although the increase in the number of cancer whole-genome sequences has revealed numerous putative non-coding cancer drivers, their information is dispersed across multiple studies making it difficult to understand their roles in tumorigenesis of different cancer types. We have developed CNCDatabase, Cornell Non-coding Cancer driver Database (https:\/\/cncdatabase.med.cornell.edu\/) that contains detailed information about predicted non-coding drivers at gene promoters, 5\u2032 and 3\u2032 UTRs (untranslated regions), enhancers, CTCF insulators and non-coding RNAs. CNCDatabase documents 1111 protein-coding genes and 90 non-coding RNAs with reported drivers in their non-coding regions from 32 cancer types by computational predictions of positive selection using whole-genome sequences; differential gene expression in samples with and without mutations; or another set of experimental validations including luciferase reporter assays and genome editing. The database can be easily modified and scaled as lists of non-coding drivers are revised in the community with larger whole-genome sequencing studies, CRISPR screens and further experimental validations. Overall, CNCDatabase provides a helpful resource for researchers to explore the pathological role of non-coding alterations in human cancers.<\/jats:p>","DOI":"10.1093\/nar\/gkaa915","type":"journal-article","created":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T07:39:25Z","timestamp":1601969965000},"page":"D1094-D1101","source":"Crossref","is-referenced-by-count":14,"title":["CNCDatabase: a database of non-coding cancer drivers"],"prefix":"10.1093","volume":"49","author":[{"given":"Eric Minwei","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York,\u00a0NY 10017, USA"},{"name":"Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA"},{"name":"Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10065, USA"},{"name":"Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10021, USA"}]},{"given":"Alexander","family":"Martinez-Fundichely","sequence":"additional","affiliation":[{"name":"Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA"},{"name":"Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10065, USA"},{"name":"Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10021, USA"}]},{"given":"Rajesh","family":"Bollapragada","sequence":"additional","affiliation":[{"name":"Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10021, USA"}]},{"given":"Maurice","family":"Spiewack","sequence":"additional","affiliation":[{"name":"Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10021, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4351-7566","authenticated-orcid":false,"given":"Ekta","family":"Khurana","sequence":"additional","affiliation":[{"name":"Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA"},{"name":"Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10065, USA"},{"name":"Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10021, USA"}]}],"member":"286","published-online":{"date-parts":[[2020,10,23]]},"reference":[{"key":"2021010313124413000_B1","article-title":"The catalogue of somatic mutations in cancer (COSMIC)","volume-title":"Current Protocols in Human Genetics","author":"Forbes","year":"2008"},{"key":"2021010313124413000_B2","doi-asserted-by":"crossref","DOI":"10.1200\/PO.17.00011","article-title":"OncoKB: a precision oncology knowledge base","author":"Chakravarty","year":"2017","journal-title":"JCO Precis. 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