{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T02:49:21Z","timestamp":1784688561621,"version":"3.55.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2020,10,26]],"date-time":"2020-10-26T00:00:00Z","timestamp":1603670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Elixir ITA","award":["2010PA3441"],"award-info":[{"award-number":["2010PA3441"]}]},{"name":"PRACE call 15","award":["2016163924"],"award-info":[{"award-number":["2016163924"]}]},{"name":"PRACE call 18","award":["2018194670"],"award-info":[{"award-number":["2018194670"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>RNA editing is a relevant epitranscriptome phenomenon able to increase the transcriptome and proteome diversity of eukaryotic organisms. ADAR mediated RNA editing is widespread in humans in which millions of A-to-I changes modify thousands of primary transcripts. RNA editing has pivotal roles in the regulation of gene expression or modulation of the innate immune response or functioning of several neurotransmitter receptors. Massive transcriptome sequencing has fostered the research in this field. Nonetheless, different aspects of the RNA editing biology are still unknown and need to be elucidated. To support the study of A-to-I RNA editing we have updated our REDIportal catalogue raising its content to about 16 millions of events detected in 9642 human RNAseq samples from the GTEx project by using a dedicated pipeline based on the HPC version of the REDItools software. REDIportal now allows searches at sample level, provides overviews of RNA editing profiles per each RNAseq experiment, implements a Gene View module to look at individual events in their genic context and hosts the CLAIRE database. Starting from this novel version, REDIportal will start collecting non-human RNA editing changes for comparative genomics investigations. The database is freely available at http:\/\/srv00.recas.ba.infn.it\/atlas\/index.html.<\/jats:p>","DOI":"10.1093\/nar\/gkaa916","type":"journal-article","created":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T19:15:51Z","timestamp":1601925351000},"page":"D1012-D1019","source":"Crossref","is-referenced-by-count":154,"title":["REDIportal: millions of novel A-to-I RNA editing events from thousands of RNAseq experiments"],"prefix":"10.1093","volume":"49","author":[{"given":"Luigi","family":"Mansi","sequence":"first","affiliation":[{"name":"Department of Biosciences, Biotechnologies and Biopharmaceutics (DBBB), University of Bari, Via Orabona 4, 70125 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco Antonio","family":"Tangaro","sequence":"additional","affiliation":[{"name":"Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies (IBIOM), National Research Council, Via Amendola 122\/O, 70126 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Lo\u00a0Giudice","sequence":"additional","affiliation":[{"name":"Department of Biosciences, Biotechnologies and Biopharmaceutics (DBBB), University of Bari, Via Orabona 4, 70125 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiziano","family":"Flati","sequence":"additional","affiliation":[{"name":"SCAI-Super Computing Applications and Innovation Department, CINECA, Via dei Tizii 6B, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eli","family":"Kopel","sequence":"additional","affiliation":[{"name":"Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, 52900 Ramat Gan, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2671-6587","authenticated-orcid":false,"given":"Amos Avraham","family":"Schaffer","sequence":"additional","affiliation":[{"name":"Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, 52900 Ramat Gan, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiziana","family":"Castrignan\u00f2","sequence":"additional","affiliation":[{"name":"Department of Ecological and Biological Sciences (DEB), University of Tuscia, Via S. Camillo de Lellis 44, 01100 Viterbo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Chillemi","sequence":"additional","affiliation":[{"name":"Department for Innovation in Biological, Agro-food and Forest systems (DIBAF), University of Tuscia, Via S. 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