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To facilitate the further development and evaluation of methods to predict these changes, we have developed ThermoMutDB, a manually curated database containing &amp;gt;14,669 experimental data of thermodynamic parameters for wild type and mutant proteins. This represents an increase of 83% in unique mutations over previous databases and includes thermodynamic information on 204 new proteins. During manual curation we have also corrected annotation errors in previously curated entries. Associated with each entry, we have included information on the unfolding Gibbs free energy and melting temperature change, and have associated entries with available experimental structural information. ThermoMutDB supports users to contribute to new data points and programmatic access to the database via a RESTful API. ThermoMutDB is freely available at: http:\/\/biosig.unimelb.edu.au\/thermomutdb.<\/jats:p>","DOI":"10.1093\/nar\/gkaa925","type":"journal-article","created":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T11:13:21Z","timestamp":1602501201000},"page":"D475-D479","source":"Crossref","is-referenced-by-count":93,"title":["ThermoMutDB: a thermodynamic database for missense mutations"],"prefix":"10.1093","volume":"49","author":[{"given":"Joicymara S","family":"Xavier","sequence":"first","affiliation":[{"name":"Institute of Agricultural Sciences, Universidade Federal dos Vales do Jequitinhonha e Mucuri"},{"name":"Instituto Ren\u00e9 Rachou, Funda\u00e7\u00e3o Oswaldo Cruz"}]},{"given":"Thanh-Binh","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Bio 21 Institute, University of Melbourne"}]},{"given":"Malancha","family":"Karmarkar","sequence":"additional","affiliation":[{"name":"Bio 21 Institute, University of Melbourne"},{"name":"Computational Biology and Clinical Informatics, Baker Heart and Diabetes Institute"}]},{"given":"Stephanie","family":"Portelli","sequence":"additional","affiliation":[{"name":"Bio 21 Institute, University of Melbourne"},{"name":"Computational Biology and Clinical Informatics, Baker Heart and Diabetes Institute"}]},{"given":"P\u00e2mela M","family":"Rezende","sequence":"additional","affiliation":[{"name":"Instituto Ren\u00e9 Rachou, Funda\u00e7\u00e3o Oswaldo Cruz"}]},{"given":"Jo\u00e3o P L","family":"Velloso","sequence":"additional","affiliation":[{"name":"Instituto Ren\u00e9 Rachou, Funda\u00e7\u00e3o Oswaldo Cruz"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2948-2413","authenticated-orcid":false,"given":"David B","family":"Ascher","sequence":"additional","affiliation":[{"name":"Bio 21 Institute, University of Melbourne"},{"name":"Computational Biology and Clinical Informatics, Baker Heart and Diabetes Institute"},{"name":"Department of Biochemistry, University of Cambridge"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3004-2119","authenticated-orcid":false,"given":"Douglas E V","family":"Pires","sequence":"additional","affiliation":[{"name":"Bio 21 Institute, University of Melbourne"},{"name":"Computational Biology and Clinical Informatics, Baker Heart and Diabetes Institute"},{"name":"School of Computing and Information Systems, University of Melbourne"}]}],"member":"286","published-online":{"date-parts":[[2020,10,23]]},"reference":[{"key":"2021010313121571500_B1","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1158\/2159-8290.CD-14-1096","article-title":"Germline mutations in the CDKN2B tumor suppressor gene predispose to renal cell carcinoma","volume":"5","author":"Jafri","year":"2015","journal-title":"Cancer Discov."},{"key":"2021010313121571500_B2","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.celrep.2017.04.029","article-title":"Huntingtin inclusions trigger cellular quiescence, deactivate apoptosis, and lead to delayed necrosis","volume":"19","author":"Ramdzan","year":"2017","journal-title":"Cell Rep."},{"key":"2021010313121571500_B3","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41525-017-0009-4","article-title":"Familial STAG2 germline mutation defines a new human cohesinopathy","volume":"2","author":"Soardi","year":"2017","journal-title":"NPJ Genom Med"},{"key":"2021010313121571500_B4","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1136\/jmedgenet-2017-105127","article-title":"Tumour risks and genotype-phenotype correlations associated with germline variants in succinate dehydrogenase subunit genes SDHB, SDHC and SDHD","volume":"55","author":"Andrews","year":"2018","journal-title":"J. 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