{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T15:54:36Z","timestamp":1793030076215,"version":"4.5.0"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2020,10,26]],"date-time":"2020-10-26T00:00:00Z","timestamp":1603670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018929","name":"German Network for Bioinformatics Infrastructure","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100018929","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100013060","name":"EMBL","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013060","id-type":"DOI","asserted-by":"publisher"}]},{"name":"JumpAR","award":["FKZ 01Kl1706"],"award-info":[{"award-number":["FKZ 01Kl1706"]}]},{"DOI":"10.13039\/501100002347","name":"Federal Ministry of Education and Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"European Research Council","doi-asserted-by":"publisher","award":["ERC-AdG-669830"],"award-info":[{"award-number":["ERC-AdG-669830"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>SMART (Simple Modular Architecture Research Tool) is a web resource (https:\/\/smart.embl.de) for the identification and annotation of protein domains and the analysis of protein domain architectures. SMART version 9 contains manually curated models for more than 1300 protein domains, with a topical set of 68 new models added since our last update article (1). All the new models are for diverse recombinase families and subfamilies and as a set they provide a comprehensive overview of mobile element recombinases namely transposase, integrase, relaxase, resolvase, cas1 casposase and Xer like cellular recombinase. Further updates include the synchronization of the underlying protein databases with UniProt (2), Ensembl (3) and STRING (4), greatly increasing the total number of annotated domains and other protein features available in architecture analysis mode. Furthermore, SMART\u2019s vector-based protein display engine has been extended and updated to use the latest web technologies and the domain architecture analysis components have been optimized to handle the increased number of protein features available.<\/jats:p>","DOI":"10.1093\/nar\/gkaa937","type":"journal-article","created":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T15:15:59Z","timestamp":1601997359000},"page":"D458-D460","source":"Crossref","is-referenced-by-count":2038,"title":["SMART: recent updates, new developments and status in 2020"],"prefix":"10.1093","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3560-4288","authenticated-orcid":false,"given":"Ivica","family":"Letunic","sequence":"first","affiliation":[{"name":"biobyte solutions GmbH, Bothestr 142, 69126 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supriya","family":"Khedkar","sequence":"additional","affiliation":[{"name":"EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peer","family":"Bork","sequence":"additional","affiliation":[{"name":"EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany"},{"name":"Max Delbr\u00fcck Centre for Molecular Medicine, Berlin, Germany"},{"name":"Department of Bioinformatics, Biocenter, University of W\u00fcrzburg, W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,10,26]]},"reference":[{"key":"2021010313124491900_B1","doi-asserted-by":"crossref","first-page":"D493","DOI":"10.1093\/nar\/gkx922","article-title":"20 years of the SMART protein domain annotation resource","volume":"46","author":"Letunic","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"2021010313124491900_B2","doi-asserted-by":"crossref","first-page":"D506","DOI":"10.1093\/nar\/gky1049","article-title":"UniProt: a worldwide hub of protein knowledge","volume":"47","author":"UniProt, C.","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"2021010313124491900_B3","first-page":"D682","article-title":"Ensembl 2020","volume":"48","author":"Yates","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"2021010313124491900_B4","doi-asserted-by":"crossref","first-page":"D607","DOI":"10.1093\/nar\/gky1131","article-title":"STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets","volume":"47","author":"Szklarczyk","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"2021010313124491900_B5","doi-asserted-by":"crossref","first-page":"5857","DOI":"10.1073\/pnas.95.11.5857","article-title":"SMART, a simple modular architecture research tool: identification of signaling domains","volume":"95","author":"Schultz","year":"1998","journal-title":"Proc. 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