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InterProScan is the underlying software that allows protein and nucleic acid sequences to be searched against InterPro's signatures. Signatures are predictive models which describe protein families, domains or sites, and are provided by multiple databases. InterPro combines signatures representing equivalent families, domains or sites, and provides additional information such as descriptions, literature references and Gene Ontology (GO) terms, to produce a comprehensive resource for protein classification. Founded in 1999, InterPro has become one of the most widely used resources for protein family annotation. Here, we report the status of InterPro (version 81.0) in its 20th year of operation, and its associated software, including updates to database content, the release of a new website and REST API, and performance improvements in InterProScan.<\/jats:p>","DOI":"10.1093\/nar\/gkaa977","type":"journal-article","created":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T11:32:10Z","timestamp":1603452730000},"page":"D344-D354","source":"Crossref","is-referenced-by-count":2109,"title":["The InterPro protein families and domains database: 20 years on"],"prefix":"10.1093","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5773-4724","authenticated-orcid":false,"given":"Matthias","family":"Blum","sequence":"first","affiliation":[{"name":"European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK"}]},{"given":"Hsin-Yu","family":"Chang","sequence":"additional","affiliation":[{"name":"European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0520-0736","authenticated-orcid":false,"given":"Sara","family":"Chuguransky","sequence":"additional","affiliation":[{"name":"European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK"}]},{"given":"Tiago","family":"Grego","sequence":"additional","affiliation":[{"name":"European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK"}]},{"given":"Swaathi","family":"Kandasaamy","sequence":"additional","affiliation":[{"name":"European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, 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European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1973-6347","authenticated-orcid":false,"given":"Shriya","family":"Raj","sequence":"additional","affiliation":[{"name":"European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3655-5660","authenticated-orcid":false,"given":"Lorna","family":"Richardson","sequence":"additional","affiliation":[{"name":"European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK"}]},{"given":"Gustavo A","family":"Salazar","sequence":"additional","affiliation":[{"name":"European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5551-8526","authenticated-orcid":false,"given":"Lowri","family":"Williams","sequence":"additional","affiliation":[{"name":"European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK"}]},{"given":"Peer","family":"Bork","sequence":"additional","affiliation":[{"name":"European Molecular Biology Laboratory, Structural and Computational Biology Unit, Meyerhofstra\u00dfe 1, 69117 Heidelberg, Germany"}]},{"given":"Alan","family":"Bridge","sequence":"additional","affiliation":[{"name":"Swiss-Prot Group, Swiss Institute of Bioinformatics, CMU, 1 rue Michel Servet, CH-1211, Geneva 4, Switzerland"}]},{"given":"Julian","family":"Gough","sequence":"additional","affiliation":[{"name":"Medical Research Council Laboratory of Molecular Biology, Cambridge Biomedical Campus, Francis Crick Ave, Trumpington, Cambridge CB2 0QH, UK"}]},{"given":"Daniel 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