{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T18:18:37Z","timestamp":1774549117590,"version":"3.50.1"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T00:00:00Z","timestamp":1604534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NNF10CC1016517"],"award-info":[{"award-number":["NNF10CC1016517"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NNF16OC0021746"],"award-info":[{"award-number":["NNF16OC0021746"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001732","name":"Danish National Research Foundation","doi-asserted-by":"publisher","award":["DNRF137"],"award-info":[{"award-number":["DNRF137"]}],"id":[{"id":"10.13039\/501100001732","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Graduate School for Experimental Plant Sciences"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Microorganisms produce natural products that are frequently used in the development of antibacterial, antiviral, and anticancer drugs, pesticides, herbicides, or fungicides. In recent years, genome mining has evolved into a prominent method to access this potential. antiSMASH is one of the most popular tools for this task. Here, we present version 3 of the antiSMASH database, providing a means to access and query precomputed antiSMASH-5.2-detected biosynthetic gene clusters from representative, publicly available, high-quality microbial genomes via an interactive graphical user interface. In version 3, the database contains 147 517 high quality BGC regions from 388 archaeal, 25 236 bacterial and 177 fungal genomes and is available at https:\/\/antismash-db.secondarymetabolites.org\/.<\/jats:p>","DOI":"10.1093\/nar\/gkaa978","type":"journal-article","created":{"date-parts":[[2020,10,10]],"date-time":"2020-10-10T19:10:03Z","timestamp":1602357003000},"page":"D639-D643","source":"Crossref","is-referenced-by-count":142,"title":["The antiSMASH database version 3: increased taxonomic coverage and new query features for modular enzymes"],"prefix":"10.1093","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3764-6051","authenticated-orcid":false,"given":"Kai","family":"Blin","sequence":"first","affiliation":[{"name":"The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kgs. Lyngby\u00a02800, Denmark"}]},{"given":"Simon","family":"Shaw","sequence":"additional","affiliation":[{"name":"The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kgs. Lyngby\u00a02800, Denmark"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9815-511X","authenticated-orcid":false,"given":"Satria A","family":"Kautsar","sequence":"additional","affiliation":[{"name":"Bioinformatics Group, Wageningen University, Wageningen\u00a06708PB, The Netherlands"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2191-2821","authenticated-orcid":false,"given":"Marnix H","family":"Medema","sequence":"additional","affiliation":[{"name":"Bioinformatics Group, Wageningen University, Wageningen\u00a06708PB, The Netherlands"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8260-5120","authenticated-orcid":false,"given":"Tilmann","family":"Weber","sequence":"additional","affiliation":[{"name":"The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kgs. Lyngby\u00a02800, Denmark"}]}],"member":"286","published-online":{"date-parts":[[2020,11,5]]},"reference":[{"key":"2021010313121931700_B1","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1021\/acs.jnatprod.9b01285","article-title":"Natural products as sources of new drugs over the nearly four decades from 01\/1981 to 09\/2019","volume":"83","author":"Newman","year":"2020","journal-title":"J. Nat. Prod."},{"key":"2021010313121931700_B2","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1039\/C6NP00025H","article-title":"The evolution of genome mining in microbes - a review","volume":"33","author":"Ziemert","year":"2016","journal-title":"Nat. Prod. Rep."},{"key":"2021010313121931700_B3","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.ijmm.2014.02.001","article-title":"In silico tools for the analysis of antibiotic biosynthetic pathways","volume":"304","author":"Weber","year":"2014","journal-title":"Int. J. Med. Microbiol."},{"key":"2021010313121931700_B4","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/nchembio.1884","article-title":"Computational approaches to natural product discovery","volume":"11","author":"Medema","year":"2015","journal-title":"Nat. Chem. Biol."},{"key":"2021010313121931700_B5","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.synbio.2015.12.002","article-title":"The secondary metabolite bioinformatics portal: computational tools to facilitate synthetic biology of secondary metabolite production","volume":"1","author":"Weber","year":"2016","journal-title":"Synth Syst Biotechnol"},{"key":"2021010313121931700_B6","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1093\/bib\/bbx146","article-title":"Recent development of antiSMASH and other computational approaches to mine secondary metabolite biosynthetic gene clusters","volume":"20","author":"Blin","year":"2019","journal-title":"Brief. Bioinform."},{"key":"2021010313121931700_B7","doi-asserted-by":"crossref","first-page":"D402","DOI":"10.1093\/nar\/gks993","article-title":"ClusterMine360: a database of microbial PKS\/NRPS biosynthesis","volume":"41","author":"Conway","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"2021010313121931700_B8","first-page":"D422","article-title":"IMG-ABC v.5.0: an update to the IMG\/Atlas of Biosynthetic Gene Clusters Knowledgebase","volume":"48","author":"Palaniappan","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"2021010313121931700_B9","doi-asserted-by":"crossref","first-page":"W339","DOI":"10.1093\/nar\/gkr466","article-title":"antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences","volume":"39","author":"Medema","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"2021010313121931700_B10","doi-asserted-by":"crossref","first-page":"W204","DOI":"10.1093\/nar\/gkt449","article-title":"antiSMASH 2.0\u2014a versatile platform for genome mining of secondary metabolite producers","volume":"41","author":"Blin","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"2021010313121931700_B11","doi-asserted-by":"crossref","first-page":"W237","DOI":"10.1093\/nar\/gkv437","article-title":"antiSMASH 3.0\u2014a comprehensive resource for the genome mining of biosynthetic gene clusters","volume":"43","author":"Weber","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"2021010313121931700_B12","doi-asserted-by":"crossref","first-page":"W36","DOI":"10.1093\/nar\/gkx319","article-title":"antiSMASH 4.0\u2014improvements in chemistry prediction and gene cluster boundary identification","volume":"45","author":"Blin","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"2021010313121931700_B13","doi-asserted-by":"crossref","first-page":"W81","DOI":"10.1093\/nar\/gkz310","article-title":"antiSMASH 5.0: updates to the secondary metabolite genome mining pipeline","volume":"47","author":"Blin","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"2021010313121931700_B14","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/nchembio.1890","article-title":"Minimum information about a biosynthetic gene cluster","volume":"11","author":"Medema","year":"2015","journal-title":"Nat. Chem. Biol."},{"key":"2021010313121931700_B15","first-page":"D454","article-title":"MIBiG 2.0: a repository for biosynthetic gene clusters of known function","volume":"48","author":"Kautsar","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"2021010313121931700_B16","doi-asserted-by":"crossref","first-page":"D555","DOI":"10.1093\/nar\/gkw960","article-title":"The antiSMASH database, a comprehensive database of microbial secondary metabolite biosynthetic gene clusters","volume":"45","author":"Blin","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"2021010313121931700_B17","doi-asserted-by":"crossref","first-page":"D625","DOI":"10.1093\/nar\/gky1060","article-title":"The antiSMASH database version 2: a comprehensive resource on secondary metabolite biosynthetic gene clusters","volume":"47","author":"Blin","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"2021010313121931700_B18","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-07641-9","article-title":"High throughput ANI analysis of 90K prokaryotic genomes reveals clear species boundaries","volume":"9","author":"Jain","year":"2018","journal-title":"Nat. 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