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Two resources produced from these efforts are: The Target Central Resource Database (TCRD) (http:\/\/juniper.health.unm.edu\/tcrd\/) and Pharos (https:\/\/pharos.nih.gov\/), a web interface to browse the TCRD. The ultimate goal of these resources is to highlight and facilitate research into currently understudied proteins, by aggregating a multitude of data sources, and ranking targets based on the amount of data available, and presenting data in machine learning ready format. Since the 2017 release, both TCRD and Pharos have produced two major releases, which have incorporated or expanded an additional 25 data sources. Recently incorporated data types include human and viral-human protein\u2013protein interactions, protein\u2013disease and protein\u2013phenotype associations, and drug-induced gene signatures, among others. These aggregated data have enabled us to generate new visualizations and content sections in Pharos, in order to empower users to find new areas of study in the druggable genome.<\/jats:p>","DOI":"10.1093\/nar\/gkaa993","type":"journal-article","created":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T19:24:19Z","timestamp":1602703459000},"page":"D1334-D1346","source":"Crossref","is-referenced-by-count":161,"title":["TCRD and Pharos 2021: mining the human proteome for disease biology"],"prefix":"10.1093","volume":"49","author":[{"given":"Timothy K","family":"Sheils","sequence":"first","affiliation":[{"name":"National Center for Advancing Translational Science, 9800 Medical Center Drive, Rockville, MD 20850, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen L","family":"Mathias","sequence":"additional","affiliation":[{"name":"Translational Informatics Division, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, 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