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Though several databases provided similar information, the majority of them are limited to literatures before 2010 and need to be updated urgently. HIT 2.0 was here constructed as the latest curated dataset focusing on Herbal Ingredients\u2019 Targets covering PubMed literatures 2000\u20132020. Currently, HIT 2.0 hosts 10 031 compound-target activity pairs with quality indicators between 2208 targets and 1237 ingredients from more than 1250 reputable herbs. The molecular targets cover those genes\/proteins being directly\/indirectly activated\/inhibited, protein binders, and enzymes substrates or products. Also included are those genes regulated under the treatment of individual ingredient. Crosslinks were made to databases of TTD, DrugBank, KEGG, PDB, UniProt, Pfam, NCBI, TCM-ID and others. More importantly, HIT enables automatic Target-mining and My-target curation from daily released PubMed literatures. Thus, users can retrieve and download the latest abstracts containing potential targets for interested compounds, even for those not yet covered in HIT. Further, users can log into \u2018My-target\u2019 system, to curate personal target-profiling on line based on retrieved abstracts. HIT can be accessible at http:\/\/hit2.badd-cao.net.<\/jats:p>","DOI":"10.1093\/nar\/gkab1011","type":"journal-article","created":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T13:47:35Z","timestamp":1636984055000},"page":"D1238-D1243","source":"Crossref","is-referenced-by-count":172,"title":["HIT 2.0: an enhanced platform for Herbal Ingredients' Targets"],"prefix":"10.1093","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0511-1423","authenticated-orcid":false,"given":"Deyu","family":"Yan","sequence":"first","affiliation":[{"name":"Dept. of Gastroenterology, Shanghai Tenth People's Hospital, School of Life Sciences and Technology, Tongji University, Shanghai\u00a0200092, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5380-2435","authenticated-orcid":false,"given":"Genhui","family":"Zheng","sequence":"additional","affiliation":[{"name":"Dept. of Gastroenterology, Shanghai Tenth People's Hospital, School of Life Sciences and Technology, Tongji University, Shanghai\u00a0200092, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caicui","family":"Wang","sequence":"additional","affiliation":[{"name":"Dept. of Gastroenterology, Shanghai Tenth People's Hospital, School of Life Sciences and Technology, Tongji University, Shanghai\u00a0200092, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zikun","family":"Chen","sequence":"additional","affiliation":[{"name":"Dept. of Gastroenterology, Shanghai Tenth People's Hospital, School of Life Sciences and Technology, Tongji University, Shanghai\u00a0200092, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiantian","family":"Mao","sequence":"additional","affiliation":[{"name":"Dept. of Gastroenterology, Shanghai Tenth People's Hospital, School of Life Sciences and Technology, Tongji University, Shanghai\u00a0200092, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Gao","sequence":"additional","affiliation":[{"name":"International Human Phenome Institutes (Shanghai), Shanghai, China"},{"name":"Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Yan","sequence":"additional","affiliation":[{"name":"Dept. of Gastroenterology, Shanghai Tenth People's Hospital, School of Life Sciences and Technology, Tongji University, Shanghai\u00a0200092, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangyi","family":"Chen","sequence":"additional","affiliation":[{"name":"Dept. of Gastroenterology, Shanghai Tenth People's Hospital, School of Life Sciences and Technology, Tongji University, Shanghai\u00a0200092, 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Gastroenterology, Shanghai Tenth People's Hospital, School of Life Sciences and Technology, Tongji University, Shanghai\u00a0200092, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenhao","family":"Han","sequence":"additional","affiliation":[{"name":"Dept. of Gastroenterology, Shanghai Tenth People's Hospital, School of Life Sciences and Technology, Tongji University, Shanghai\u00a0200092, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengdi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Dept. of Gastroenterology, Shanghai Tenth People's Hospital, School of Life Sciences and Technology, Tongji University, Shanghai\u00a0200092, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Dept. of Gastroenterology, Shanghai Tenth People's Hospital, School of Life Sciences and Technology, Tongji University, Shanghai\u00a0200092, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[{"name":"Dept. of Gastroenterology, Shanghai Tenth People's Hospital, School of Life Sciences and Technology, Tongji University, Shanghai\u00a0200092, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0508-6056","authenticated-orcid":false,"given":"Kailin","family":"Tang","sequence":"additional","affiliation":[{"name":"Dept. of Gastroenterology, Shanghai Tenth People's Hospital, School of Life Sciences and Technology, Tongji University, Shanghai\u00a0200092, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiwei","family":"Cao","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Fudan University, Shanghai 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