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Here, we update the ViRBase database to version 3.0 (http:\/\/www.virbase.org\/ or http:\/\/www.rna-society.org\/virbase\/). This update represents a major revision: (i) the total number of interaction entries is now greater than 820,000, an approximately 70-fold increment, involving 116 virus and 36 host organisms, (ii) it supplements and provides more details on RNA annotations (including RNA editing, RNA localization and RNA modification), ncRNA SNP and ncRNA-drug related information and (iii) it provides two additional tools for predicting binding sites (IntaRNA and PRIdictor), a visual plug-in to display interactions and a website which is optimized for more practical and user-friendly operation. Overall, ViRBase v3.0 provides a more comprehensive resource for virus and host ncRNA-associated interactions enabling researchers a more effective means for investigation of viral infections.<\/jats:p>","DOI":"10.1093\/nar\/gkab1029","type":"journal-article","created":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T20:54:10Z","timestamp":1634158450000},"page":"D928-D933","source":"Crossref","is-referenced-by-count":34,"title":["ViRBase v3.0: a virus and host ncRNA-associated interaction repository with increased coverage and annotation"],"prefix":"10.1093","volume":"50","author":[{"given":"Jun","family":"Cheng","sequence":"first","affiliation":[{"name":"Affiliated Foshan Maternity and Child Healthcare Hospital, Southern Medical University (Foshan Maternity & Child Healthcare Hospital), Foshan 528000, China"}]},{"given":"Yunqing","family":"Lin","sequence":"additional","affiliation":[{"name":"Center for Cell Lineage and Atlas (CCLA), Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Guangzhou 510005, China"}]},{"given":"Linfu","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China"}]},{"given":"Kechen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China"}]},{"given":"Qi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China"}]},{"given":"Kaixin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China"}]},{"given":"Lin","family":"Ning","sequence":"additional","affiliation":[{"name":"Dermatology Hospital, Southern Medical University, Guangzhou 510091, China"}]},{"given":"Juanjuan","family":"Kang","sequence":"additional","affiliation":[{"name":"Affiliated Foshan Maternity and Child Healthcare Hospital, Southern Medical University (Foshan Maternity & Child Healthcare Hospital), Foshan 528000, China"}]},{"given":"Tianyu","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China"}]},{"given":"Yan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China"}]},{"given":"Xiaoyang","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Organ Failure Research, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0988-7405","authenticated-orcid":false,"given":"Dong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China"},{"name":"Dermatology Hospital, Southern Medical University, Guangzhou 510091, China"}]},{"given":"Yanhui","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Peking University Health Science Center, Beijing, PR China"}]},{"given":"Xi","family":"Su","sequence":"additional","affiliation":[{"name":"Affiliated Foshan Maternity and Child Healthcare Hospital, Southern Medical University (Foshan Maternity & Child Healthcare Hospital), Foshan 528000, China"}]},{"given":"Bin","family":"Yang","sequence":"additional","affiliation":[{"name":"Dermatology Hospital, Southern Medical University, Guangzhou 510091, China"}]}],"member":"286","published-online":{"date-parts":[[2021,11,1]]},"reference":[{"key":"2022010507394732300_B1","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.3390\/v12121374","article-title":"Non-coding RNAs and SARS-related coronaviruses","volume":"12","author":"Henzinger","year":"2020","journal-title":"Viruses"},{"key":"2022010507394732300_B2","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1146\/annurev.micro.112408.134243","article-title":"Viruses, microRNAs, and host interactions","volume":"64","author":"Skalsky","year":"2010","journal-title":"Annu. 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