{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T01:58:10Z","timestamp":1778810290276,"version":"3.51.4"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2021,11,8]],"date-time":"2021-11-08T00:00:00Z","timestamp":1636329600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2019YFA0802202"],"award-info":[{"award-number":["2019YFA0802202"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFA0504400"],"award-info":[{"award-number":["2017YFA0504400"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91940304"],"award-info":[{"award-number":["91940304"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31971228"],"award-info":[{"award-number":["31971228"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31770879"],"award-info":[{"award-number":["31770879"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31771459"],"award-info":[{"award-number":["31771459"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31970604"],"award-info":[{"award-number":["31970604"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31770879"],"award-info":[{"award-number":["31770879"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31900903"],"award-info":[{"award-number":["31900903"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81702945"],"award-info":[{"award-number":["81702945"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Youth science and technology innovation talent of guangdong TeZhi plan","award":["2019TQ05Y181"],"award-info":[{"award-number":["2019TQ05Y181"]}]},{"name":"Guangdong Province","award":["2021A1515010542"],"award-info":[{"award-number":["2021A1515010542"]}]},{"name":"Guangzhou city","award":["202002030351"],"award-info":[{"award-number":["202002030351"]}]},{"name":"Guangzhou city","award":["201904020041"],"award-info":[{"award-number":["201904020041"]}]},{"DOI":"10.13039\/501100002402","name":"Sun Yat-sen University","doi-asserted-by":"publisher","award":["20lgpy112"],"award-info":[{"award-number":["20lgpy112"]}],"id":[{"id":"10.13039\/501100002402","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002402","name":"Sun Yat-sen University","doi-asserted-by":"publisher","award":["2021qntd26"],"award-info":[{"award-number":["2021qntd26"]}],"id":[{"id":"10.13039\/501100002402","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019318","name":"Guangdong Province Key Laboratory of Computational Science","doi-asserted-by":"publisher","award":["13lgjc05"],"award-info":[{"award-number":["13lgjc05"]}],"id":[{"id":"10.13039\/501100019318","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Guangdong Province Computational Science Innovative Research Team","award":["14lgjc18"],"award-info":[{"award-number":["14lgjc18"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>RNA polymerase III (Pol III) transcribes hundreds of non-coding RNA genes (ncRNAs), which involve in a variety of cellular processes. However, the expression, functions, regulatory networks and evolution of these Pol III-transcribed ncRNAs are still largely unknown. In this study, we developed a novel resource, Pol3Base (http:\/\/rna.sysu.edu.cn\/pol3base\/), to decode the interactome, expression, evolution, epitranscriptome and disease variations of Pol III-transcribed ncRNAs. The current release of Pol3Base includes thousands of regulatory relationships between \u223c79 000 ncRNAs and transcription factors by mining 56 ChIP-seq datasets. By integrating CLIP-seq datasets, we deciphered the interactions of these ncRNAs with &amp;gt;240 RNA binding proteins. Moreover, Pol3Base contains \u223c9700 RNA modifications located within thousands of Pol III-transcribed ncRNAs. Importantly, we characterized expression profiles of ncRNAs in &amp;gt;70 tissues and 28 different tumor types. In addition, by comparing these ncRNAs from human and mouse, we revealed about 4000 evolutionary conserved ncRNAs. We also identified \u223c11 403 tRNA-derived small RNAs (tsRNAs) in 32 different tumor types. Finally, by analyzing somatic mutation data, we investigated the mutation map of these ncRNAs to help uncover their potential roles in diverse diseases. This resource will help expand our understanding of potential functions and regulatory networks of Pol III-transcribed ncRNAs.<\/jats:p>","DOI":"10.1093\/nar\/gkab1033","type":"journal-article","created":{"date-parts":[[2021,10,16]],"date-time":"2021-10-16T10:07:08Z","timestamp":1634378828000},"page":"D279-D286","source":"Crossref","is-referenced-by-count":12,"title":["Pol3Base: a resource for decoding the interactome, expression, evolution, epitranscriptome and disease variations of Pol III-transcribed ncRNAs"],"prefix":"10.1093","volume":"50","author":[{"given":"Li","family":"Cai","sequence":"first","affiliation":[{"name":"MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory for Biocontrol, School of Life Sciences,\u00a0The Fifth Affiliated Hospital,\u00a0Sun Yat-sen University, Guangdong, Guangzhou 510275, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiajia","family":"Xuan","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory for Biocontrol, School of Life Sciences,\u00a0The Fifth Affiliated Hospital,\u00a0Sun Yat-sen University, Guangdong, Guangzhou 510275, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiao","family":"Lin","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory for Biocontrol, School of Life Sciences,\u00a0The Fifth Affiliated Hospital,\u00a0Sun Yat-sen University, Guangdong, Guangzhou 510275, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junhao","family":"Wang","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory for Biocontrol, School of Life Sciences,\u00a0The Fifth Affiliated Hospital,\u00a0Sun Yat-sen University, Guangdong, Guangzhou 510275, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shurong","family":"Liu","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory for Biocontrol, School of Life Sciences,\u00a0The Fifth Affiliated Hospital,\u00a0Sun Yat-sen University, Guangdong, Guangzhou 510275, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fangzhou","family":"Xie","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory for Biocontrol, School of Life Sciences,\u00a0The Fifth Affiliated Hospital,\u00a0Sun Yat-sen University, Guangdong, Guangzhou 510275, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7152-1095","authenticated-orcid":false,"given":"Lingling","family":"Zheng","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory for Biocontrol, School of Life Sciences,\u00a0The Fifth Affiliated Hospital,\u00a0Sun Yat-sen University, Guangdong, Guangzhou 510275, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Li","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory for Biocontrol, School of Life Sciences,\u00a0The Fifth Affiliated Hospital,\u00a0Sun Yat-sen University, Guangdong, Guangzhou 510275, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3657-2863","authenticated-orcid":false,"given":"Lianghu","family":"Qu","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory for Biocontrol, School of Life Sciences,\u00a0The Fifth Affiliated Hospital,\u00a0Sun Yat-sen University, Guangdong, Guangzhou 510275, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3863-2786","authenticated-orcid":false,"given":"Jianhua","family":"Yang","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory for Biocontrol, School of Life Sciences,\u00a0The Fifth Affiliated Hospital,\u00a0Sun Yat-sen University, Guangdong, Guangzhou 510275, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,11,8]]},"reference":[{"key":"2022010507342790500_B1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1146\/annurev-biochem-062917-012624","article-title":"Signaling to and from the RNA polymerase III transcription and processing machinery","volume":"87","author":"Willis","year":"2018","journal-title":"Annu. Rev. Biochem."},{"key":"2022010507342790500_B2","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1038\/nrc2539","article-title":"Non-coding RNA production by RNA polymerase III is implicated in cancer","volume":"8","author":"Marshall","year":"2008","journal-title":"Nat. Rev. Cancer"},{"key":"2022010507342790500_B3","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/nrg3001","article-title":"Transcription by RNA polymerase III: more complex than we thought","volume":"12","author":"White","year":"2011","journal-title":"Nat. Rev. Genet."},{"key":"2022010507342790500_B4","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.tig.2007.09.001","article-title":"The expanding RNA polymerase III transcriptome","volume":"23","author":"Dieci","year":"2007","journal-title":"Trends Genet."},{"key":"2022010507342790500_B5","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1101\/gad.333989.119","article-title":"RNA polymerase III transcription as a disease factor","volume":"34","author":"Yeganeh","year":"2020","journal-title":"Genes Dev."},{"key":"2022010507342790500_B6","doi-asserted-by":"crossref","first-page":"4826","DOI":"10.1093\/nar\/gkl656","article-title":"Spatial organization of transcription by RNA polymerase III","volume":"34","author":"Haeusler","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"2022010507342790500_B7","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.cell.2010.09.002","article-title":"Molecular basis of RNA polymerase III transcription repression by Maf1","volume":"143","author":"Vannini","year":"2010","journal-title":"Cell"},{"key":"2022010507342790500_B8","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/j.cell.2015.11.005","article-title":"Redox signaling by the RNA polymerase III TFIIB-related factor Brf2","volume":"163","author":"Gouge","year":"2015","journal-title":"Cell"},{"key":"2022010507342790500_B9","doi-asserted-by":"crossref","first-page":"3757","DOI":"10.1093\/nar\/gkn272","article-title":"Recruitment of RNA polymerase III in vivo","volume":"36","author":"Kenneth","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"2022010507342790500_B10","doi-asserted-by":"crossref","first-page":"9444","DOI":"10.1093\/nar\/gky656","article-title":"Function of TFIIIC, RNA polymerase III initiation factor, in activation and repression of tRNA gene transcription","volume":"46","author":"Ciesla","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"2022010507342790500_B11","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1101\/gr.101337.109","article-title":"Defining the RNA polymerase III transcriptome: genome-wide localization of the RNA polymerase III transcription machinery in human cells","volume":"20","author":"Canella","year":"2010","journal-title":"Genome Res."},{"key":"2022010507342790500_B12","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/nsmb.1794","article-title":"Genomic binding profiles of functionally distinct RNA polymerase III transcription complexes in human cells","volume":"17","author":"Moqtaderi","year":"2010","journal-title":"Nat. Struct. Mol. Biol."},{"key":"2022010507342790500_B13","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1101\/gr.161570.113","article-title":"Gene duplication and neofunctionalization: POLR3G and POLR3GL","volume":"24","author":"Renaud","year":"2014","journal-title":"Genome research"},{"key":"2022010507342790500_B14","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1101\/gr.201400.115","article-title":"Human MAF1 targets and represses active RNA polymerase III genes by preventing recruitment rather than inducing long-term transcriptional arrest","volume":"26","author":"Orioli","year":"2016","journal-title":"Genome Res."},{"key":"2022010507342790500_B15","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s11427-014-4764-5","article-title":"CLIP: viewing the RNA world from an RNA-protein interactome perspective","volume":"58","author":"Zhang","year":"2015","journal-title":"Sci. China Life Sci."},{"key":"2022010507342790500_B16","doi-asserted-by":"crossref","first-page":"D327","DOI":"10.1093\/nar\/gkx934","article-title":"RMBase v2.0: deciphering the map of RNA modifications from epitranscriptome sequencing data","volume":"46","author":"Xuan","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"2022010507342790500_B17","doi-asserted-by":"crossref","first-page":"D259","DOI":"10.1093\/nar\/gkv1036","article-title":"RMBase: a resource for decoding the landscape of RNA modifications from high-throughput sequencing data","volume":"44","author":"Sun","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"2022010507342790500_B18","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/s41586-020-2493-4","article-title":"Expanded encyclopaedias of DNA elements in the human and mouse genomes","volume":"583","author":"Moore","year":"2020","journal-title":"Nature"},{"key":"2022010507342790500_B19","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1038\/ng.2764","article-title":"The cancer genome atlas pan-cancer analysis project","volume":"45","author":"Weinstein","year":"2013","journal-title":"Nat. Genet."},{"key":"2022010507342790500_B20","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1038\/nsmb.1801","article-title":"Human RNA polymerase III transcriptomes and relationships to Pol II promoter chromatin and enhancer-binding factors","volume":"17","author":"Oler","year":"2010","journal-title":"Nat. Struct. Mol. Biol."},{"key":"2022010507342790500_B21","doi-asserted-by":"crossref","first-page":"D991","DOI":"10.1093\/nar\/gks1193","article-title":"NCBI GEO: archive for functional genomics data sets\u2013update","volume":"41","author":"Barrett","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"2022010507342790500_B22","doi-asserted-by":"crossref","first-page":"D794","DOI":"10.1093\/nar\/gkx1081","article-title":"The Encyclopedia of DNA elements (ENCODE): data portal update","volume":"46","author":"Davis","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"2022010507342790500_B23","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.12688\/f1000research.15931.1","article-title":"FastQ Screen: a tool for multi-genome mapping and quality control","volume":"7","author":"Wingett","year":"2018","journal-title":"F1000Res"},{"key":"2022010507342790500_B24","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat. Methods"},{"key":"2022010507342790500_B25","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","article-title":"The Sequence Alignment\/Map format and SAMtools","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"2022010507342790500_B26","doi-asserted-by":"crossref","first-page":"R137","DOI":"10.1186\/gb-2008-9-9-r137","article-title":"Model-based analysis of ChIP-Seq (MACS)","volume":"9","author":"Zhang","year":"2008","journal-title":"Genome Biol."},{"key":"2022010507342790500_B27","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.molcel.2010.05.004","article-title":"Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities","volume":"38","author":"Heinz","year":"2010","journal-title":"Mol. Cell"},{"key":"2022010507342790500_B28","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1101\/gr.229102","article-title":"The human genome browser at UCSC","volume":"12","author":"Kent","year":"2002","journal-title":"Genome Res."},{"key":"2022010507342790500_B29","doi-asserted-by":"crossref","first-page":"D766","DOI":"10.1093\/nar\/gky955","article-title":"GENCODE reference annotation for the human and mouse genomes","volume":"47","author":"Frankish","year":"2019","journal-title":"Nucleic. Acids. Res."},{"key":"2022010507342790500_B30","doi-asserted-by":"crossref","first-page":"D92","DOI":"10.1093\/nar\/gkt1248","article-title":"starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data","volume":"42","author":"Li","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"2022010507342790500_B31","doi-asserted-by":"crossref","first-page":"D203","DOI":"10.1093\/nar\/gky830","article-title":"POSTAR2: deciphering the post-transcriptional regulatory logics","volume":"47","author":"Zhu","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"2022010507342790500_B32","doi-asserted-by":"crossref","first-page":"11.12.1","DOI":"10.1002\/0471250953.bi1112s47","article-title":"BEDTools: the Swiss-Army Tool for genome feature analysis","volume":"47","author":"Quinlan","year":"2014","journal-title":"Curr. Protoc. Bioinformatics"},{"key":"2022010507342790500_B33","doi-asserted-by":"crossref","first-page":"D941","DOI":"10.1093\/nar\/gky1015","article-title":"COSMIC: the Catalogue Of Somatic Mutations In Cancer","volume":"47","author":"Tate","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"2022010507342790500_B34","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nature12477","article-title":"Signatures of mutational processes in human cancer","volume":"500","author":"Alexandrov","year":"2013","journal-title":"Nature"},{"key":"2022010507342790500_B35","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nature12912","article-title":"Discovery and saturation analysis of cancer genes across 21 tumour types","volume":"505","author":"Lawrence","year":"2014","journal-title":"Nature"},{"key":"2022010507342790500_B36","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"key":"2022010507342790500_B37","doi-asserted-by":"crossref","first-page":"W185","DOI":"10.1093\/nar\/gkw414","article-title":"tRF2Cancer: a web server to detect tRNA-derived small RNA fragments (tRFs) and their expression in multiple cancers","volume":"44","author":"Zheng","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"2022010507342790500_B38","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1186\/1471-2105-10-421","article-title":"BLAST+: architecture and applications","volume":"10","author":"Camacho","year":"2009","journal-title":"BMC Bioinformatics"},{"key":"2022010507342790500_B39","doi-asserted-by":"crossref","first-page":"e1601","DOI":"10.1002\/wrna.1601","article-title":"Classification and function of RNA-protein interactions","author":"Liu","year":"2020","journal-title":"Wiley Interdiscip. Rev. RNA"},{"key":"2022010507342790500_B40","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/s41576-020-00302-y","article-title":"RNA-binding proteins in human genetic disease","volume":"22","author":"Gebauer","year":"2021","journal-title":"Nat. Rev. Genet."},{"key":"2022010507342790500_B41","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1016\/j.ymthe.2020.09.013","article-title":"Transfer RNA-derived small RNAs: another layer of gene regulation and novel targets for disease therapeutics","volume":"28","author":"Kim","year":"2020","journal-title":"Mol. Ther."},{"key":"2022010507342790500_B42","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1093\/jmcb\/mjz049","article-title":"POLIII-derived non-coding RNAs acting as scaffolds and decoys","volume":"11","author":"Tauber","year":"2019","journal-title":"J. Mol. Cell Biol."},{"key":"2022010507342790500_B43","doi-asserted-by":"crossref","first-page":"e161","DOI":"10.1038\/mtna.2014.12","article-title":"Pol III promoters to express small RNAs: delineation of transcription initiation","volume":"3","author":"Ma","year":"2014","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"2022010507342790500_B44","doi-asserted-by":"crossref","first-page":"D184","DOI":"10.1093\/nar\/gkv1309","article-title":"GtRNAdb 2.0: an expanded database of transfer RNA genes identified in complete and draft genomes","volume":"44","author":"Chan","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"2022010507342790500_B45","doi-asserted-by":"crossref","first-page":"D159","DOI":"10.1093\/nar\/gkn772","article-title":"tRNAdb 2009: compilation of tRNA sequences and tRNA genes","volume":"37","author":"Juhling","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"2022010507342790500_B46","first-page":"D256","article-title":"T-psi-C: user friendly database of tRNA sequences and structures","volume":"48","author":"Sajek","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"2022010507342790500_B47","doi-asserted-by":"crossref","first-page":"D210","DOI":"10.1093\/nar\/gkq1007","article-title":"tRNADB-CE 2011: tRNA gene database curated manually by experts","volume":"39","author":"Abe","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"2022010507342790500_B48","doi-asserted-by":"crossref","first-page":"D155","DOI":"10.1093\/nar\/gky1141","article-title":"miRBase: from microRNA sequences to function","volume":"47","author":"Kozomara","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"2022010507342790500_B49","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1261\/rna.043687.113","article-title":"circBase: a database for circular RNAs","volume":"20","author":"Glazar","year":"2014","journal-title":"RNA"},{"key":"2022010507342790500_B50","doi-asserted-by":"crossref","first-page":"D165","DOI":"10.1093\/nar\/gkaa1046","article-title":"NONCODEV6: an updated database dedicated to long non-coding RNA annotation in both animals and plants","volume":"49","author":"Zhao","year":"2021","journal-title":"Nucleic Acids Res."}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/nar\/article-pdf\/50\/D1\/D279\/42057974\/gkab1033.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/nar\/article-pdf\/50\/D1\/D279\/42057974\/gkab1033.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,11]],"date-time":"2023-11-11T08:03:54Z","timestamp":1699689834000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article\/50\/D1\/D279\/6423189"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,8]]},"references-count":50,"journal-issue":{"issue":"D1","published-online":{"date-parts":[[2021,11,8]]},"published-print":{"date-parts":[[2022,1,7]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gkab1033","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,1,7]]},"published":{"date-parts":[[2021,11,8]]}}}