{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T10:46:09Z","timestamp":1783334769022,"version":"3.54.6"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2021,11,27]],"date-time":"2021-11-27T00:00:00Z","timestamp":1637971200000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32070674"],"award-info":[{"award-number":["32070674"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Program of Guangdong Basic and Applied Basic Research Fund","award":["2020B1515120069"],"award-info":[{"award-number":["2020B1515120069"]}]},{"name":"Shenzhen City and Longgang District for the Warshel Institute for Computational Biology"},{"name":"Guangdong Young Scholar Development Fund","award":["2021E0005"],"award-info":[{"award-number":["2021E0005"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32070659"],"award-info":[{"award-number":["32070659"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010877","name":"Science, Technology and Innovation Commission of Shenzhen Municipality","doi-asserted-by":"publisher","award":["JCYJ20200109150003938"],"award-info":[{"award-number":["JCYJ20200109150003938"]}],"id":[{"id":"10.13039\/501100010877","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Guangdong Province Basic and Applied Basic Research Fund","award":["2021A1515012447"],"award-info":[{"award-number":["2021A1515012447"]}]},{"name":"Ganghong Young Scholar Development Fund","award":["2021E007"],"award-info":[{"award-number":["2021E007"]}]},{"name":"Shenzhen Science and Technology","award":["JCYJ20190808102405474"],"award-info":[{"award-number":["JCYJ20190808102405474"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Circular RNAs (circRNAs), which are single-stranded RNA molecules that have individually formed into a covalently closed continuous loop, act as sponges of microRNAs to regulate transcription and translation. CircRNAs are important molecules in the field of cancer diagnosis, as growing evidence suggests that they are closely related to pathological cancer features. Therefore, they have high potential for clinical use as novel cancer biomarkers. In this article, we present our updates to CircNet (version 2.0), into which circRNAs from circAtlas and MiOncoCirc, and novel circRNAs from The Cancer Genome Atlas database have been integrated. In total, 2732 samples from 37 types of cancers were integrated into CircNet 2.0 and analyzed using several of the most reliable circRNA detection algorithms. Furthermore, target miRNAs were predicted from the full-length circRNA sequence using three reliable tools (PITA, miRanda and TargetScan). Additionally, 384\u00a0897 experimentally verified miRNA\u2013target interactions from miRTarBase were integrated into our database to facilitate the construction of high-quality circRNA\u2013miRNA\u2013gene regulatory networks. These improvements, along with the user-friendly interactive web interface for data presentation, search, and visualization, showcase the updated CircNet database as a powerful, experimentally validated resource, for providing strong data support in the biomedical fields. CircNet 2.0 is currently accessible at https:\/\/awi.cuhk.edu.cn\/\u223cCircNet.<\/jats:p>","DOI":"10.1093\/nar\/gkab1036","type":"journal-article","created":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T19:13:34Z","timestamp":1635189214000},"page":"D93-D101","source":"Crossref","is-referenced-by-count":72,"title":["CircNet 2.0: an updated database for exploring circular RNA regulatory networks in cancers"],"prefix":"10.1093","volume":"50","author":[{"given":"Yigang","family":"Chen","sequence":"first","affiliation":[{"name":"The Genetics Laboratory, Longgang District Maternity & Child Healthcare Hospital of Shenzhen City, Shenzhen, Guangdong Province\u00a0518172, China"},{"name":"School of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen 518172, China"},{"name":"Warshel Institute for Computational Biology, The Chinese University of Hong Kong, Shenzhen 518172, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lantian","family":"Yao","sequence":"additional","affiliation":[{"name":"Warshel Institute for Computational Biology, The Chinese University of Hong Kong, Shenzhen 518172, China"},{"name":"School of Science and Engineering, The Chinese University of Hong Kong, Shenzhen 518172, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Tang","sequence":"additional","affiliation":[{"name":"School of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen 518172, China"},{"name":"Warshel Institute for Computational Biology, The Chinese University of Hong Kong, Shenzhen 518172, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6158-5207","authenticated-orcid":false,"given":"Jhih-Hua","family":"Jhong","sequence":"additional","affiliation":[{"name":"Warshel Institute for Computational Biology, The Chinese University of Hong Kong, Shenzhen 518172, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingting","family":"Wan","sequence":"additional","affiliation":[{"name":"School of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen 518172, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyue","family":"Chang","sequence":"additional","affiliation":[{"name":"School of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen 518172, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shidong","family":"Cui","sequence":"additional","affiliation":[{"name":"School of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen 518172, China"},{"name":"Warshel Institute for Computational Biology, The Chinese University of Hong Kong, Shenzhen 518172, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijun","family":"Luo","sequence":"additional","affiliation":[{"name":"School of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen 518172, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxuan","family":"Cai","sequence":"additional","affiliation":[{"name":"School of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen 518172, China"},{"name":"Warshel Institute for Computational Biology, The Chinese University of Hong Kong, Shenzhen 518172, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenshuo","family":"Li","sequence":"additional","affiliation":[{"name":"Warshel Institute for Computational Biology, The Chinese University of Hong Kong, Shenzhen 518172, China"},{"name":"School of Science and Engineering, The Chinese University of Hong Kong, Shenzhen 518172, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Chen","sequence":"additional","affiliation":[{"name":"Warshel Institute for Computational Biology, The Chinese University of Hong Kong, Shenzhen 518172, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsi-Yuan","family":"Huang","sequence":"additional","affiliation":[{"name":"The Genetics Laboratory, Longgang District Maternity & Child Healthcare Hospital of Shenzhen City, Shenzhen, Guangdong Province\u00a0518172, China"},{"name":"School of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen 518172, China"},{"name":"Warshel Institute for Computational Biology, The Chinese University of Hong Kong, Shenzhen 518172, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7076-8432","authenticated-orcid":false,"given":"Zhuo","family":"Wang","sequence":"additional","affiliation":[{"name":"Warshel Institute for Computational Biology, The Chinese University of Hong Kong, Shenzhen 518172, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiming","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Data Science, The Chinese University of Hong Kong, Shenzhen 518172, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu-Hao","family":"Chang","sequence":"additional","affiliation":[{"name":"Graduate Institute of Biomedical Informatics, Taipei Medical University, Taipei 110, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengxiang","family":"Wei","sequence":"additional","affiliation":[{"name":"The Genetics Laboratory, Longgang District Maternity & Child Healthcare Hospital of Shenzhen City, Shenzhen, Guangdong Province\u00a0518172, China"},{"name":"Department of Cell Biology, Jiamusi University, Jiamusi, Heilongjiang Province 154007, China"},{"name":"Shenzhen Children's Hospital of China Medical University, Shenzhen, Guangdong Province\u00a0518172, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8475-7868","authenticated-orcid":false,"given":"Tzong-Yi","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen 518172, China"},{"name":"Warshel Institute for Computational Biology, The Chinese University of Hong Kong, Shenzhen 518172, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2857-7023","authenticated-orcid":false,"given":"Hsien-Da","family":"Huang","sequence":"additional","affiliation":[{"name":"The Genetics Laboratory, Longgang District Maternity & Child Healthcare Hospital of Shenzhen City, Shenzhen, Guangdong Province\u00a0518172, China"},{"name":"School of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen 518172, China"},{"name":"Warshel Institute for Computational Biology, The Chinese University of Hong Kong, Shenzhen 518172, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,11,26]]},"reference":[{"key":"2022010507373767400_B1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1261\/rna.035667.112","article-title":"Circular RNAs are abundant, conserved, and associated with ALU repeats","volume":"19","author":"Jeck","year":"2013","journal-title":"RNA"},{"key":"2022010507373767400_B2","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/978-981-13-1426-1_6","article-title":"Circular RNAs Act as miRNA Sponges","volume":"1087","author":"Panda","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"2022010507373767400_B3","doi-asserted-by":"crossref","first-page":"5588","DOI":"10.1002\/jcp.27384","article-title":"Circular RNA in cardiovascular disease","volume":"234","author":"Altesha","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"2022010507373767400_B4","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/978-981-13-1426-1_19","article-title":"Circular RNA and Alzheimer's disease","volume":"1087","author":"Akhter","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"2022010507373767400_B5","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s40659-020-00309-z","article-title":"The roles of miRNA, lncRNA and circRNA in the development of osteoporosis","volume":"53","author":"Yang","year":"2020","journal-title":"Biol. Res."},{"key":"2022010507373767400_B6","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.ymthe.2019.01.006","article-title":"circRNA.33186 contributes to the pathogenesis of osteoarthritis by sponging miR-127-5p","volume":"27","author":"Zhou","year":"2019","journal-title":"Mol. Ther."},{"key":"2022010507373767400_B7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12282-017-0793-9","article-title":"CircRNA: a novel type of biomarker for cancer","volume":"25","author":"Zhang","year":"2018","journal-title":"Breast Cancer"},{"key":"2022010507373767400_B8","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.cca.2015.02.018","article-title":"Using circular RNA as a novel type of biomarker in the screening of gastric cancer","volume":"444","author":"Li","year":"2015","journal-title":"Clin. Chim. Acta"},{"key":"2022010507373767400_B9","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1002\/1878-0261.12468","article-title":"The circRNA-microRNA code: emerging implications for cancer diagnosis and treatment","volume":"13","author":"Verduci","year":"2019","journal-title":"Mol. Oncol."},{"key":"2022010507373767400_B10","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1007\/s00018-019-03345-5","article-title":"CircRNA: a rising star in gastric cancer","volume":"77","author":"Li","year":"2020","journal-title":"Cell. Mol. Life Sci.: CMLS"},{"key":"2022010507373767400_B11","doi-asserted-by":"crossref","first-page":"255","DOI":"10.2174\/1566523219666190716092203","article-title":"The Therapeutic Potential and Role of miRNA, lncRNA, and circRNA in Osteoarthritis","volume":"19","author":"Wu","year":"2019","journal-title":"Curr. Gene Ther."},{"key":"2022010507373767400_B12","doi-asserted-by":"crossref","first-page":"D209","DOI":"10.1093\/nar\/gkv940","article-title":"CircNet: a database of circular RNAs derived from transcriptome sequencing data","volume":"44","author":"Liu","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"2022010507373767400_B13","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s13059-020-02018-y","article-title":"CircAtlas: an integrated resource of one million highly accurate circular RNAs from 1070 vertebrate transcriptomes","volume":"21","author":"Wu","year":"2020","journal-title":"Genome Biol."},{"key":"2022010507373767400_B14","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.cell.2018.12.021","article-title":"The landscape of circular RNA in cancer","volume":"176","author":"Vo","year":"2019","journal-title":"Cell"},{"key":"2022010507373767400_B15","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1093\/bib\/bbx014","article-title":"Circular RNA identification based on multiple seed matching","volume":"19","author":"Gao","year":"2018","journal-title":"Brief. Bioinform."},{"key":"2022010507373767400_B16","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s13059-014-0571-3","article-title":"CIRI: an efficient and unbiased algorithm for de novo circular RNA identification","volume":"16","author":"Gao","year":"2015","journal-title":"Genome Biol."},{"key":"2022010507373767400_B17","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/978-1-4939-8808-2_10","article-title":"Genome-wide annotation of circRNAs and their alternative back-splicing\/splicing with CIRCexplorer pipeline","volume":"1870","author":"Dong","year":"2019","journal-title":"Methods Mol. Biol."},{"key":"2022010507373767400_B18","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1093\/bioinformatics\/btv656","article-title":"Specific identification and quantification of circular RNAs from sequencing data","volume":"32","author":"Cheng","year":"2016","journal-title":"Bioinformatics"},{"key":"2022010507373767400_B19","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nature11928","article-title":"Circular RNAs are a large class of animal RNAs with regulatory potency","volume":"495","author":"Memczak","year":"2013","journal-title":"Nature"},{"key":"2022010507373767400_B20","first-page":"226","article-title":"Effectiveness of the miranda acquiescence questionnaire for investigating impaired miranda reasoning","volume":"48","author":"Rogers","year":"2020","journal-title":"J. Am. Acad. Psychiatry Law"},{"key":"2022010507373767400_B21","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1038\/ng2135","article-title":"The role of site accessibility in microRNA target recognition","volume":"39","author":"Kertesz","year":"2007","journal-title":"Nat. Genet."},{"key":"2022010507373767400_B22","doi-asserted-by":"crossref","first-page":"e05005","DOI":"10.7554\/eLife.05005","article-title":"Predicting effective microRNA target sites in mammalian mRNAs","volume":"4","author":"Agarwal","year":"2015","journal-title":"Elife"},{"key":"2022010507373767400_B23","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s13073-019-0614-1","article-title":"Reconstruction of full-length circular RNAs enables isoform-level quantification","volume":"11","author":"Zheng","year":"2019","journal-title":"Genome Med"},{"key":"2022010507373767400_B24","first-page":"D148","article-title":"miRTarBase 2020: updates to the experimentally validated microRNA-target interaction database","volume":"48","author":"Huang","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"2022010507373767400_B25","doi-asserted-by":"crossref","first-page":"D991","DOI":"10.1093\/nar\/gks1193","article-title":"NCBI GEO: archive for functional genomics data sets\u2013update","volume":"41","author":"Barrett","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"2022010507373767400_B26","article-title":"CSCD2: an integrated interactional database of cancer-specific circular RNAs","author":"Feng","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"2022010507373767400_B27","doi-asserted-by":"crossref","first-page":"D155","DOI":"10.1093\/nar\/gky1141","article-title":"miRBase: from microRNA sequences to function","volume":"47","author":"Kozomara","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"2022010507373767400_B28","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/s41588-020-0669-3","article-title":"Guidelines for human gene nomenclature","volume":"52","author":"Bruford","year":"2020","journal-title":"Nat. Genet."},{"key":"2022010507373767400_B29","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1261\/rna.043687.113","article-title":"circBase: a database for circular RNAs","volume":"20","author":"Gla\u017ear","year":"2014","journal-title":"RNA"},{"key":"2022010507373767400_B30","doi-asserted-by":"crossref","first-page":"D325","DOI":"10.1093\/nar\/gkaa1113","article-title":"The Gene Ontology resource: enriching a GOld mine","volume":"49","author":"Gene Ontology Consortium","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"2022010507373767400_B31","doi-asserted-by":"crossref","first-page":"D353","DOI":"10.1093\/nar\/gkw1092","article-title":"KEGG: new perspectives on genomes, pathways, diseases and drugs","volume":"45","author":"Kanehisa","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"2022010507373767400_B32","first-page":"D845","article-title":"The DisGeNET knowledge platform for disease genomics: 2019 update","volume":"48","author":"Pi\u00f1ero","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"2022010507373767400_B33","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/s41587-020-0546-8","article-title":"Visualizing and interpreting cancer genomics data via the Xena platform","volume":"38","author":"Goldman","year":"2020","journal-title":"Nat. Biotechnol."},{"key":"2022010507373767400_B34","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s12943-019-1031-1","article-title":"Circular RNA circTRIM33-12 acts as the sponge of MicroRNA-191 to suppress hepatocellular carcinoma progression","volume":"18","author":"Zhang","year":"2019","journal-title":"Mol. Cancer"},{"key":"2022010507373767400_B35","doi-asserted-by":"crossref","first-page":"5829","DOI":"10.1038\/s41388-018-0369-y","article-title":"A circular RNA circ-DNMT1 enhances breast cancer progression by activating autophagy","volume":"37","author":"Du","year":"2018","journal-title":"Oncogene"},{"key":"2022010507373767400_B36","doi-asserted-by":"crossref","first-page":"4812","DOI":"10.1158\/0008-5472.CAN-18-0532","article-title":"CircNT5E acts as a sponge of miR-422a to promote glioblastoma tumorigenesis","volume":"78","author":"Wang","year":"2018","journal-title":"Cancer Res."},{"key":"2022010507373767400_B37","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s12943-019-1113-0","article-title":"Circular RNAs in the tumour microenvironment","volume":"19","author":"Ma","year":"2020","journal-title":"Mol. Cancer"},{"key":"2022010507373767400_B38","doi-asserted-by":"crossref","first-page":"373","DOI":"10.3892\/ijmm.2017.2852","article-title":"Microarray analysis of circular RNA expression patterns in polarized macrophages","volume":"39","author":"Zhang","year":"2017","journal-title":"Int. J. Mol. Med."},{"key":"2022010507373767400_B39","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.exphem.2018.10.011","article-title":"CircPAN3 mediates drug resistance in acute myeloid leukemia through the miR-153-5p\/miR-183-5p-XIAP axis","volume":"70","author":"Shang","year":"2019","journal-title":"Exp. Hematol."},{"key":"2022010507373767400_B40","doi-asserted-by":"crossref","first-page":"5259","DOI":"10.18632\/aging.102945","article-title":"Whole-transcriptome analysis reveals a potential hsa_circ_0001955\/hsa_circ_0000977-mediated miRNA-mRNA regulatory sub-network in colorectal cancer","volume":"12","author":"Ding","year":"2020","journal-title":"Aging"},{"key":"2022010507373767400_B41","doi-asserted-by":"crossref","first-page":"D92","DOI":"10.1093\/nar\/gkt1248","article-title":"starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data","volume":"42","author":"Li","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"2022010507373767400_B42","doi-asserted-by":"crossref","first-page":"3563","DOI":"10.1080\/15384101.2020.1852746","article-title":"The circ_0004463\/miR-380-3p\/FOXO1 axis modulates mitochondrial respiration and bladder cancer cell apoptosis","volume":"19","author":"Wu","year":"2020","journal-title":"Cell Cycle"}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/nar\/article-pdf\/50\/D1\/D93\/42058277\/gkab1036.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/nar\/article-pdf\/50\/D1\/D93\/42058277\/gkab1036.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T08:11:28Z","timestamp":1641370288000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article\/50\/D1\/D93\/6444342"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,26]]},"references-count":42,"journal-issue":{"issue":"D1","published-online":{"date-parts":[[2021,11,26]]},"published-print":{"date-parts":[[2022,1,7]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gkab1036","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,1,7]]},"published":{"date-parts":[[2021,11,26]]}}}