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Since the last update in 2015, the complex genomes of numerous Brassicaceae species have been decoded, accompanied by many omics datasets. To provide an up-to-date service, we report here a major upgrade of the portal. The Model-View-ViewModel (MVVM) framework of BRAD has been re-engineered to enable easy and sustainable maintenance of the database. The collection of genomes has been increased to 26 species, along with optimization of the user interface. Features of the previous version have been retained, with additional new tools for exploring syntenic genes, gene expression\u00a0and variation data. In the \u2018Syntenic Gene @ Subgenome\u2019 module, we added features to view the sequence alignment and phylogenetic relationships of syntenic genes. New modules include \u2018MicroSynteny\u2019 for viewing synteny of selected fragment pairs, and \u2018Polymorph\u2019 for retrieval of variation data. The updated BRAD provides a substantial expansion of genomic data and a comprehensive improvement of the service available to the Brassicaceae research community.<\/jats:p>","DOI":"10.1093\/nar\/gkab1057","type":"journal-article","created":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T13:48:11Z","timestamp":1634651291000},"page":"D1432-D1441","source":"Crossref","is-referenced-by-count":221,"title":["BRAD V3.0: an upgraded Brassicaceae database"],"prefix":"10.1093","volume":"50","author":[{"given":"Haixu","family":"Chen","sequence":"first","affiliation":[{"name":"Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, No.12, Haidian District, Beijing\u00a0100081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianpeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, No.12, Haidian District, Beijing\u00a0100081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoning","family":"He","sequence":"additional","affiliation":[{"name":"Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, No.12, Haidian District, Beijing\u00a0100081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Cai","sequence":"additional","affiliation":[{"name":"Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, No.12, Haidian District, Beijing\u00a0100081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runmao","family":"Lin","sequence":"additional","affiliation":[{"name":"Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, No.12, Haidian District, Beijing\u00a0100081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianli","family":"Liang","sequence":"additional","affiliation":[{"name":"Institute of Vegetables and Flowers, Chinese Academy of 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