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To date, COVID-19 remains a life-threatening pandemic with little to no targeted therapeutic recourse. The discovery of novel antiviral agents, such as vaccines and drugs, can provide therapeutic solutions to save human beings from severe infections; however, there is no specifically effective antiviral treatment confirmed for now. Thus, great attention has been paid to the use of natural or artificial antimicrobial peptides (AMPs) as these compounds are widely regarded as promising solutions for the treatment of harmful microorganisms. Given the biological significance of AMPs, it was obvious that there was a significant need for a single platform for identifying and engaging with AMP data. This led to the creation of the dbAMP platform that provides comprehensive information about AMPs and facilitates their investigation and analysis. To date, the dbAMP has accumulated 26\u00a0447 AMPs and 2262 antimicrobial proteins from 3044 organisms using both database integration and manual curation of &amp;gt;4579 articles. In addition, dbAMP facilitates the evaluation of AMP structures using I-TASSER for automated protein structure prediction and structure-based functional annotation, providing predictive structure information for clinical drug development. Next-generation sequencing (NGS) and third-generation sequencing have been applied to generate large-scale sequencing reads from various environments, enabling greatly improved analysis of genome structure. In this update, we launch an efficient online tool that can effectively identify AMPs from genome\/metagenome and proteome data of all species in a short period. In conclusion, these improvements promote the dbAMP as one of the most abundant and comprehensively annotated resources for AMPs. The updated dbAMP is now freely accessible at http:\/\/awi.cuhk.edu.cn\/dbAMP.<\/jats:p>","DOI":"10.1093\/nar\/gkab1080","type":"journal-article","created":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T11:09:38Z","timestamp":1635160178000},"page":"D460-D470","source":"Crossref","is-referenced-by-count":162,"title":["dbAMP 2.0: updated resource for antimicrobial peptides with an enhanced scanning method for genomic and proteomic data"],"prefix":"10.1093","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6158-5207","authenticated-orcid":false,"given":"Jhih-Hua","family":"Jhong","sequence":"first","affiliation":[{"name":"Warshel Institute for Computational Biology, The Chinese University of Hong Kong, Shenzhen 518172, China"}]},{"given":"Lantian","family":"Yao","sequence":"additional","affiliation":[{"name":"Warshel Institute for Computational Biology, The Chinese University of Hong Kong, Shenzhen 518172, China"},{"name":"School of Science and Engineering, The 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Taiwan"}]},{"given":"Rulan","family":"Wang","sequence":"additional","affiliation":[{"name":"Warshel Institute for Computational Biology, The Chinese University of Hong Kong, Shenzhen 518172, China"},{"name":"School of Science and Engineering, The Chinese University of Hong Kong, Shenzhen\u00a0518172, China"}]},{"given":"Shangfu","family":"Li","sequence":"additional","affiliation":[{"name":"Warshel Institute for Computational Biology, The Chinese University of Hong Kong, Shenzhen 518172, China"}]},{"given":"Wenshuo","family":"Li","sequence":"additional","affiliation":[{"name":"Warshel Institute for Computational Biology, The Chinese University of Hong Kong, Shenzhen 518172, China"},{"name":"School of Science and Engineering, The Chinese University of Hong Kong, Shenzhen\u00a0518172, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6762-6249","authenticated-orcid":false,"given":"Mengqi","family":"Luo","sequence":"additional","affiliation":[{"name":"Warshel Institute for Computational 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Shenzhen\u00a0518172, China"}]},{"given":"Qifan","family":"Cheng","sequence":"additional","affiliation":[{"name":"School of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen\u00a0518172, China"}]},{"given":"Chunxuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Warshel Institute for Computational Biology, The Chinese University of Hong Kong, Shenzhen 518172, China"}]},{"given":"Kun","family":"Xi","sequence":"additional","affiliation":[{"name":"Warshel Institute for Computational Biology, The Chinese University of Hong Kong, Shenzhen 518172, China"}]},{"given":"Li-Ching","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Engineering, National Central University, Taoyuan\u00a032001, Taiwan"}]},{"given":"Tzu-Hao","family":"Chang","sequence":"additional","affiliation":[{"name":"Graduate Institute of Biomedical Informatics, Taipei Medical University, Taipei\u00a010675, Taiwan"}]},{"given":"Jorng-Tzong","family":"Horng","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Information Engineering, National Central University, Taoyuan\u00a032001, Taiwan"}]},{"given":"Lizhe","family":"Zhu","sequence":"additional","affiliation":[{"name":"Warshel Institute for Computational Biology, The Chinese University of Hong Kong, Shenzhen 518172, China"},{"name":"School of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen\u00a0518172, China"}]},{"given":"Ying-Chih","family":"Chiang","sequence":"additional","affiliation":[{"name":"School of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen\u00a0518172, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7076-8432","authenticated-orcid":false,"given":"Zhuo","family":"Wang","sequence":"additional","affiliation":[{"name":"Warshel Institute for Computational Biology, The Chinese University of Hong Kong, Shenzhen 518172, 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