{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T18:32:08Z","timestamp":1781893928057,"version":"3.54.5"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T00:00:00Z","timestamp":1637280000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Shanghai Science and Technology Innovation Action Plan","award":["20JC1419000"],"award-info":[{"award-number":["20JC1419000"]}]},{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["2020CXJQ02"],"award-info":[{"award-number":["2020CXJQ02"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81872294"],"award-info":[{"award-number":["81872294"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072694"],"award-info":[{"award-number":["82072694"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173063"],"award-info":[{"award-number":["82173063"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2019J01170"],"award-info":[{"award-number":["2019J01170"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Extracellular vesicles (EVs) are small membranous vesicles that contain an abundant cargo of different RNA species with specialized functions and clinical implications. Here, we introduce an updated online database (http:\/\/www.exoRBase.org), exoRBase 2.0, which is a repository of EV long RNAs (termed exLRs) derived from RNA-seq data analyses of diverse human body fluids. In exoRBase 2.0, the number of exLRs has increased to 19 643 messenger RNAs (mRNAs), 15 645 long non-coding RNAs (lncRNAs)\u00a0and 79 084 circular RNAs (circRNAs) obtained from \u223c1000 human blood, urine, cerebrospinal fluid (CSF) and bile samples. Importantly, exoRBase 2.0 not only integrates and compares exLR expression profiles but also visualizes the pathway-level functional changes and the heterogeneity of origins of circulating EVs in the context of different physiological and pathological conditions. Our database provides an attractive platform for the identification of novel exLR signatures from human biofluids that will aid in the discovery of new circulating biomarkers to improve disease diagnosis and therapy.<\/jats:p>","DOI":"10.1093\/nar\/gkab1085","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T11:11:12Z","timestamp":1634814672000},"page":"D118-D128","source":"Crossref","is-referenced-by-count":193,"title":["exoRBase 2.0: an atlas of mRNA, lncRNA and circRNA in extracellular vesicles from human biofluids"],"prefix":"10.1093","volume":"50","author":[{"given":"Hongyan","family":"Lai","sequence":"first","affiliation":[{"name":"Department of Integrative Oncology, Fudan University Shanghai Cancer Center, and Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology), Institutes of Biomedical Sciences, Fudan University, Shanghai, China"},{"name":"Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Integrative Oncology, Fudan University Shanghai Cancer Center, and Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology), Institutes of Biomedical Sciences, Fudan University, Shanghai, China"},{"name":"Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hena","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Integrative Oncology, Fudan University Shanghai Cancer Center, and Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology), Institutes of Biomedical Sciences, Fudan University, Shanghai, China"},{"name":"Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Integrative Oncology, Fudan University Shanghai Cancer Center, and Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology), Institutes of Biomedical Sciences, Fudan University, Shanghai, China"},{"name":"Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiatao","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China"},{"name":"Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Integrative Oncology, Fudan University Shanghai Cancer Center, and Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology), Institutes of Biomedical Sciences, Fudan University, Shanghai, China"},{"name":"Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Integrative Oncology, Fudan University Shanghai Cancer Center, and Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology), Institutes of Biomedical Sciences, Fudan University, Shanghai, China"},{"name":"Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Integrative Oncology, Fudan University Shanghai Cancer Center, and Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology), Institutes of Biomedical Sciences, Fudan University, Shanghai, China"},{"name":"Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiping","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Second Affiliated Hospital of Fujian Medical University, Quanzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Integrative Oncology, Fudan University Shanghai Cancer Center, and Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology), Institutes of Biomedical Sciences, Fudan University, Shanghai, China"},{"name":"Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Integrative Oncology, Fudan University Shanghai Cancer Center, and Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology), Institutes of Biomedical Sciences, Fudan University, Shanghai, China"},{"name":"Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China"},{"name":"Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Integrative Oncology, Fudan University Shanghai Cancer Center, and Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology), Institutes of Biomedical Sciences, Fudan University, Shanghai, China"},{"name":"Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaohui","family":"Huang","sequence":"additional","affiliation":[{"name":"Wuxi Cancer Institute, Affiliated Hospital of Jiangnan University, Wuxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1279-0794","authenticated-orcid":false,"given":"Shenglin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Integrative Oncology, Fudan University Shanghai Cancer Center, and Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology), Institutes of Biomedical Sciences, Fudan University, Shanghai, China"},{"name":"Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,11,19]]},"reference":[{"key":"2022010507302568300_B1","doi-asserted-by":"crossref","first-page":"1535750","DOI":"10.1080\/20013078.2018.1535750","article-title":"Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines","volume":"7","author":"Th\u00e9ry","year":"2018","journal-title":"J. Extracell. Vesicles"},{"key":"2022010507302568300_B2","doi-asserted-by":"crossref","first-page":"3163","DOI":"10.1038\/s41596-021-00551-z","article-title":"Using single-vesicle technologies to unravel the heterogeneity of extracellular vesicles","volume":"16","author":"Bordanaba-Florit","year":"2021","journal-title":"Nat. Protoc."},{"key":"2022010507302568300_B3","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.cell.2019.02.018","article-title":"exRNA atlas analysis reveals distinct extracellular RNA cargo types and their carriers present across human biofluids","volume":"177","author":"Murillo","year":"2019","journal-title":"Cell"},{"key":"2022010507302568300_B4","doi-asserted-by":"crossref","first-page":"108552","DOI":"10.1016\/j.celrep.2020.108552","article-title":"Charting extracellular transcriptomes in the human biofluid RNA atlas","volume":"33","author":"Hulstaert","year":"2020","journal-title":"Cell Rep."},{"key":"2022010507302568300_B5","doi-asserted-by":"crossref","first-page":"D516","DOI":"10.1093\/nar\/gky1029","article-title":"Vesiclepedia 2019: a compendium of RNA, proteins, lipids and metabolites in extracellular vesicles","volume":"47","author":"Pathan","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"2022010507302568300_B6","doi-asserted-by":"crossref","first-page":"27066","DOI":"10.3402\/jev.v4.27066","article-title":"Biological properties of extracellular vesicles and their physiological functions","volume":"4","author":"Y\u00e1\u00f1ez-M\u00f3","year":"2015","journal-title":"J. Extracell. Vesicles"},{"key":"2022010507302568300_B7","doi-asserted-by":"crossref","first-page":"D354","DOI":"10.1093\/nar\/gkx854","article-title":"miRandola 2017: a curated knowledge base of non-invasive biomarkers","volume":"46","author":"Russo","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"2022010507302568300_B8","doi-asserted-by":"crossref","first-page":"100647","DOI":"10.1016\/j.drup.2019.100647","article-title":"Extracellular vesicles as a novel source of biomarkers in liquid biopsies for monitoring cancer progression and drug resistance","volume":"47","author":"Vasconcelos","year":"2019","journal-title":"Drug Resist. Updat."},{"key":"2022010507302568300_B9","doi-asserted-by":"crossref","first-page":"202","DOI":"10.3389\/fimmu.2019.00202","article-title":"Transcriptome of extracellular vesicles: state-of-the-art","volume":"10","author":"Turchinovich","year":"2019","journal-title":"Front. Immunol."},{"key":"2022010507302568300_B10","doi-asserted-by":"crossref","first-page":"e002372","DOI":"10.1136\/jitc-2021-002372","article-title":"uPAR extracellular vesicles: a robust biomarker of resistance to checkpoint inhibitor immunotherapy in metastatic melanoma patients","volume":"9","author":"Porcelli","year":"2021","journal-title":"J. Immunother. Cancer"},{"key":"2022010507302568300_B11","first-page":"148","article-title":"Extracellular vesicles as a promising biomarker resource in liquid biopsy for cancer","volume":"2","author":"Tamura","year":"2021","journal-title":"Extracell. Vesicles Circ. Nucleic Acids"},{"key":"2022010507302568300_B12","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/s41375-020-01104-1","article-title":"Clinical relevance of extracellular vesicles in hematological neoplasms: from liquid biopsy to cell biopsy","volume":"35","author":"Trino","year":"2021","journal-title":"Leukemia"},{"key":"2022010507302568300_B13","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1373\/clinchem.2018.301291","article-title":"Extracellular vesicles long RNA sequencing reveals abundant mRNA, circRNA, and lncRNA in human blood as potential biomarkers for cancer diagnosis","volume":"65","author":"Li","year":"2019","journal-title":"Clin. Chem."},{"key":"2022010507302568300_B14","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1136\/gutjnl-2019-318860","article-title":"Plasma extracellular vesicle long RNA profiling identifies a diagnostic signature for the detection of pancreatic ductal adenocarcinoma","volume":"69","author":"Yu","year":"2020","journal-title":"Gut"},{"key":"2022010507302568300_B15","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.1016\/j.csbj.2020.10.002","article-title":"EV-origin: enumerating the tissue-cellular origin of circulating extracellular vesicles using exLR profile","volume":"18","author":"Li","year":"2020","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"2022010507302568300_B16","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/s41467-017-02261-1","article-title":"Engineered nanointerfaces for microfluidic isolation and molecular profiling of tumor-specific extracellular vesicles","volume":"9","author":"Re\u00e1tegui","year":"2018","journal-title":"Nat. Commun."},{"key":"2022010507302568300_B17","doi-asserted-by":"crossref","first-page":"15002","DOI":"10.18632\/aging.103559","article-title":"Five-lncRNA signature in plasma exosomes serves as diagnostic biomarker for esophageal squamous cell carcinoma","volume":"12","author":"Jiao","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"2022010507302568300_B18","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s12943-021-01349-z","article-title":"Circulating exosomal mRNA profiling identifies novel signatures for the detection of prostate cancer","volume":"20","author":"Ji","year":"2021","journal-title":"Mol. Cancer"},{"key":"2022010507302568300_B19","doi-asserted-by":"crossref","first-page":"eabb3461","DOI":"10.1126\/sciadv.abb3461","article-title":"Plasma-derived extracellular vesicle analysis and deconvolution enable prediction and tracking of melanoma checkpoint blockade outcome","volume":"6","author":"Shi","year":"2020","journal-title":"Sci. Adv."},{"key":"2022010507302568300_B20","doi-asserted-by":"crossref","first-page":"D106","DOI":"10.1093\/nar\/gkx891","article-title":"exoRBase: a database of circRNA, lncRNA and mRNA in human blood exosomes","volume":"46","author":"Li","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"2022010507302568300_B21","article-title":"EVAtlas: a comprehensive database for ncRNA expression in human extracellular vesicles","author":"Liu","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"2022010507302568300_B22","doi-asserted-by":"crossref","first-page":"D962","DOI":"10.1093\/nar\/gkaa850","article-title":"LncExpDB: an expression database of human long non-coding RNAs","volume":"49","author":"Li","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"2022010507302568300_B23","doi-asserted-by":"crossref","first-page":"118092","DOI":"10.1016\/j.lfs.2020.118092","article-title":"ExoceRNA atlas: a database of cancer ceRNAs in human blood exosomes","volume":"257","author":"Xu","year":"2020","journal-title":"Life Sci."},{"key":"2022010507302568300_B24","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1126\/science.aaz1776","article-title":"The GTEx consortium atlas of genetic regulatory effects across human tissues","volume":"369","author":"The GTEx Consortium.","year":"2020","journal-title":"Science"},{"key":"2022010507302568300_B25","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/j.csbj.2019.08.001","article-title":"ASJA: a program for assembling splice junctions analysis","volume":"17","author":"Zhao","year":"2019","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"2022010507302568300_B26","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"key":"2022010507302568300_B27","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"2022010507302568300_B28","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"key":"2022010507302568300_B29","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1093\/bib\/bbx014","article-title":"Circular RNA identification based on multiple seed matching","volume":"19","author":"Gao","year":"2018","journal-title":"Brief. Bioinform."},{"key":"2022010507302568300_B30","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/nrg3813","article-title":"A census of human RNA-binding proteins","volume":"15","author":"Gerstberger","year":"2014","journal-title":"Nat. Rev. Genet."},{"key":"2022010507302568300_B31","doi-asserted-by":"crossref","first-page":"e127317","DOI":"10.1172\/jci.insight.127317","article-title":"Detection of circulating extracellular mRNAs by modified small-RNA-sequencing analysis","volume":"5","author":"Akat","year":"2019","journal-title":"JCI Insight"},{"key":"2022010507302568300_B32","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1093\/bioinformatics\/btr260","article-title":"Molecular signatures database (MSigDB) 3.0","volume":"27","author":"Liberzon","year":"2011","journal-title":"Bioinformatics"},{"key":"2022010507302568300_B33","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.cels.2015.12.004","article-title":"The Molecular Signatures Database (MSigDB) hallmark gene set collection","volume":"1","author":"Liberzon","year":"2015","journal-title":"Cell Syst."},{"key":"2022010507302568300_B34","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1089\/152791601750294344","article-title":"BioCarta","volume":"2","author":"Nishimura","year":"2001","journal-title":"Biotech. Softw. Internet Rep."},{"key":"2022010507302568300_B35","doi-asserted-by":"crossref","first-page":"D353","DOI":"10.1093\/nar\/gkw1092","article-title":"KEGG: new perspectives on genomes, pathways, diseases and drugs","volume":"45","author":"Kanehisa","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"2022010507302568300_B36","first-page":"D498","article-title":"The reactome pathway knowledgebase","volume":"48","author":"Jassal","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"2022010507302568300_B37","doi-asserted-by":"crossref","first-page":"D330","DOI":"10.1093\/nar\/gky1055","article-title":"The Gene Ontology Resource: 20 years and still GOing strong","volume":"47","author":"The Gene Ontology Consortium","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"2022010507302568300_B38","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nature08460","article-title":"Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1","volume":"462","author":"Barbie","year":"2009","journal-title":"Nature"},{"key":"2022010507302568300_B39","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2105-14-7","article-title":"GSVA: gene set variation analysis for microarray and RNA-seq data","volume":"14","author":"H\u00e4nzelmann","year":"2013","journal-title":"BMC Bioinformatics"},{"key":"2022010507302568300_B40","doi-asserted-by":"crossref","first-page":"4489","DOI":"10.1038\/s41467-020-18311-0","article-title":"Purification of HCC-specific extracellular vesicles on nanosubstrates for early HCC detection by digital scoring","volume":"11","author":"Sun","year":"2020","journal-title":"Nat. Commun."}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/nar\/article-pdf\/50\/D1\/D118\/42057550\/gkab1085.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/nar\/article-pdf\/50\/D1\/D118\/42057550\/gkab1085.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T07:44:39Z","timestamp":1641368679000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article\/50\/D1\/D118\/6431819"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,19]]},"references-count":40,"journal-issue":{"issue":"D1","published-online":{"date-parts":[[2021,11,19]]},"published-print":{"date-parts":[[2022,1,7]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gkab1085","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,1,7]]},"published":{"date-parts":[[2021,11,19]]}}}