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Through Expasy (https:\/\/www.expasy.org), the Swiss Bioinformatics Resource Portal, the scientific community worldwide, freely accesses more than 160 SIB resources supporting a wide range of life science and biomedical research areas. In 2020, Expasy was redesigned through a user-centric approach, known as User-Centred Design (UCD), whose aim is to create user interfaces that are easy-to-use, efficient and targeting the intended community. This approach, widely used in other fields such as marketing, e-commerce, and design of mobile applications, is still scarcely explored in bioinformatics. In total, around 50 people were actively involved, including internal stakeholders and end-users. In addition to an optimised interface that meets users' needs and expectations, the new version of Expasy provides an up-to-date and accurate description of high-quality resources based on a standardised ontology, allowing to connect functionally-related resources.<\/jats:p>","DOI":"10.1093\/nar\/gkab225","type":"journal-article","created":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T11:39:53Z","timestamp":1617277193000},"page":"W216-W227","source":"Crossref","is-referenced-by-count":828,"title":["Expasy, the Swiss Bioinformatics Resource Portal, as designed by its users"],"prefix":"10.1093","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7892-9678","authenticated-orcid":false,"given":"S\u00e9verine","family":"Duvaud","sequence":"first","affiliation":[{"name":"SIB Swiss Institute of Bioinformatics, Quartier Sorge - B\u00e2timent Amphip\u00f4le, CH-1015 Lausanne, Switzerland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7104-5025","authenticated-orcid":false,"given":"Chiara","family":"Gabella","sequence":"additional","affiliation":[{"name":"SIB Swiss Institute of Bioinformatics, Quartier Sorge - B\u00e2timent Amphip\u00f4le, CH-1015 Lausanne, Switzerland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0948-4537","authenticated-orcid":false,"given":"Fr\u00e9d\u00e9rique","family":"Lisacek","sequence":"additional","affiliation":[{"name":"Proteome Informatics Group, SIB Swiss Institute of Bioinformatics, and Computer Science Department, University of Geneva, CH-1227 Geneva, Switzerland"},{"name":"Section of Biology, University of Geneva, CH-1205 Geneva, Switzerland"}]},{"given":"Heinz","family":"Stockinger","sequence":"additional","affiliation":[{"name":"SIB Swiss Institute of Bioinformatics, Quartier Sorge - B\u00e2timent Amphip\u00f4le, CH-1015 Lausanne, Switzerland"}]},{"given":"Vassilios","family":"Ioannidis","sequence":"additional","affiliation":[{"name":"SIB Swiss Institute of Bioinformatics, Quartier Sorge - B\u00e2timent Amphip\u00f4le, CH-1015 Lausanne, Switzerland"}]},{"given":"Christine","family":"Durinx","sequence":"additional","affiliation":[{"name":"SIB Swiss Institute of Bioinformatics, Quartier Sorge - B\u00e2timent Amphip\u00f4le, CH-1015 Lausanne, Switzerland"}]}],"member":"286","published-online":{"date-parts":[[2021,4,13]]},"reference":[{"key":"2021070811581168000_B1","doi-asserted-by":"crossref","first-page":"D8","DOI":"10.1093\/nar\/gkx1095","article-title":"Database resources of the National Center for Biotechnology Information","volume":"46","author":"Agarwala","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"2021070811581168000_B2","doi-asserted-by":"crossref","first-page":"D15","DOI":"10.1093\/nar\/gky1124","article-title":"The European Bioinformatics Institute in 2018: Tools, infrastructure and training","volume":"47","author":"Cook","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"2021070811581168000_B3","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1186\/s13059-019-1772-6","article-title":"The bio.tools registry of software tools and data resources for the life sciences","volume":"20","author":"Ison","year":"2019","journal-title":"Genome Biol."},{"key":"2021070811581168000_B4","doi-asserted-by":"crossref","first-page":"W689","DOI":"10.1093\/nar\/gkq394","article-title":"BioCatalogue: A universal catalogue of web services for the life sciences","volume":"38","author":"Bhagat","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"2021070811581168000_B5","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/0968-0004(94)90153-8","article-title":"A new generation of information retrieval tools for biologists: the example of the ExPASy WWW server","volume":"19","author":"Appel","year":"1994","journal-title":"Trends Biochem. 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