{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T20:36:45Z","timestamp":1775335005658,"version":"3.50.1"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"W1","license":[{"start":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T00:00:00Z","timestamp":1620259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000854","name":"Human Frontier Science Program","doi-asserted-by":"publisher","award":["RGP0002\/2016"],"award-info":[{"award-number":["RGP0002\/2016"]}],"id":[{"id":"10.13039\/501100000854","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Recent innovations in genetics and imaging are providing the means to reconstruct cell lineages, either by tracking cell divisions using live microscopy, or by deducing the history of cells using molecular recorders. A cell lineage on its own, however, is simply a description of cell divisions as branching events. A major goal of current research is to integrate this description of cell relationships with information about the spatial distribution and identities of the cells those divisions produce. Visualizing, interpreting and exploring these complex data in an intuitive manner requires the development of new tools. Here we present CeLaVi, a web-based visualization tool that allows users to navigate and interact with a representation of cell lineages, whilst simultaneously visualizing the spatial distribution, identities and properties of cells. CeLaVi\u2019s principal functions include the ability to explore and manipulate the cell lineage tree; to visualise the spatial distribution of cell clones at different depths of the tree; to colour cells in the 3D viewer based on lineage relationships; to visualise various cell qualities on the 3D viewer (e.g. gene expression, cell type) and to annotate selected cells\/clones. All these capabilities are demonstrated with four different example data sets. CeLaVi is available at http:\/\/www.celavi.pro.<\/jats:p>","DOI":"10.1093\/nar\/gkab325","type":"journal-article","created":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T22:41:56Z","timestamp":1619044916000},"page":"W80-W85","source":"Crossref","is-referenced-by-count":17,"title":["CeLaVi: an interactive cell lineage visualization tool"],"prefix":"10.1093","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3188-9784","authenticated-orcid":false,"given":"Irepan","family":"Salvador-Mart\u00ednez","sequence":"first","affiliation":[{"name":"Centre for Life\u2019s Origins and Evolution, Department of Genetics Evolution and Environment, University College London, Gower Street, London, WC1E 6BT, UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2155-0645","authenticated-orcid":false,"given":"Marco","family":"Grillo","sequence":"additional","affiliation":[{"name":"Institut de G\u00e9nomique Fonctionnelle de Lyon (IGFL), \u00c9cole Normale Sup\u00e9rieure de Lyon, 32 avenue Tony Garnier, 69007 Lyon, France"},{"name":"Centre National de la Recherche Scientifique (CNRS), France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6803-7251","authenticated-orcid":false,"given":"Michalis","family":"Averof","sequence":"additional","affiliation":[{"name":"Institut de G\u00e9nomique Fonctionnelle de Lyon (IGFL), \u00c9cole Normale Sup\u00e9rieure de Lyon, 32 avenue Tony Garnier, 69007 Lyon, France"},{"name":"Centre National de la Recherche Scientifique (CNRS), France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3749-5620","authenticated-orcid":false,"given":"Maximilian\u00a0J","family":"Telford","sequence":"additional","affiliation":[{"name":"Centre for Life\u2019s Origins and Evolution, Department of Genetics Evolution and Environment, University College London, Gower Street, London, WC1E 6BT, UK"}]}],"member":"286","published-online":{"date-parts":[[2021,5,6]]},"reference":[{"key":"2021070812051430600_B1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1749-6632.1898.tb54960.x","article-title":"Considerations on cell-lineage and ancestral reminiscence: based on re-examination of some points in the early development of annelids and polyclades","volume":"11","author":"Wilson","year":"1898","journal-title":"Ann. 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Commun."}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/nar\/article-pdf\/49\/W1\/W80\/38842278\/gkab325.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/nar\/article-pdf\/49\/W1\/W80\/38842278\/gkab325.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T17:04:56Z","timestamp":1625763896000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article\/49\/W1\/W80\/6270768"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,6]]},"references-count":20,"journal-issue":{"issue":"W1","published-online":{"date-parts":[[2021,5,6]]},"published-print":{"date-parts":[[2021,7,2]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gkab325","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.12.14.422765","asserted-by":"object"}]},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,7,2]]},"published":{"date-parts":[[2021,5,6]]}}}