{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T01:55:19Z","timestamp":1783734919482,"version":"3.55.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"W1","license":[{"start":{"date-parts":[[2021,5,23]],"date-time":"2021-05-23T00:00:00Z","timestamp":1621728000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004100","name":"Labex","doi-asserted-by":"publisher","award":["ANR-11-LABX-0037-01"],"award-info":[{"award-number":["ANR-11-LABX-0037-01"]}],"id":[{"id":"10.13039\/501100004100","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004100","name":"Labex","doi-asserted-by":"publisher","award":["ANR-11-IDEX-0004-02"],"award-info":[{"award-number":["ANR-11-IDEX-0004-02"]}],"id":[{"id":"10.13039\/501100004100","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The ever-increasing number of genomic and metagenomic sequences accumulating in our databases requires accurate approaches to explore their content against specific domain targets. MyCLADE is a user-friendly webserver designed for targeted functional profiling of genomic and metagenomic sequences based on a database of a few million probabilistic models of Pfam domains. It uses the MetaCLADE multi-source domain annotation strategy, modelling domains based on multiple probabilistic profiles. MyCLADE takes a list of protein sequences and possibly a target set of domains\/clans as input and, for each sequence, it provides a domain architecture built from the targeted domains or from all Pfam domains. It is linked to the Pfam and QuickGO databases in multiple ways for easy retrieval of domain and clan information. E-value, bit-score, domain-dependent probability scores and logos representing the match of the model with the sequence are provided to help the user to assess the quality of each annotation. Availability and implementation: MyCLADE is freely available at http:\/\/www.lcqb.upmc.fr\/myclade.<\/jats:p>","DOI":"10.1093\/nar\/gkab395","type":"journal-article","created":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T12:57:45Z","timestamp":1619701065000},"page":"W452-W458","source":"Crossref","is-referenced-by-count":12,"title":["MyCLADE: a multi-source domain annotation server for sequence functional exploration"],"prefix":"10.1093","volume":"49","author":[{"given":"Riccardo","family":"Vicedomini","sequence":"first","affiliation":[{"name":"Sorbonne Universit\u00e9, CNRS, IBPS, Laboratoire de Biologie Computationnelle et Quantitative (LCQB), UMR 7238, Paris 75005, France"},{"name":"Sorbonne Universit\u00e9, CNRS, Institut des Sciences du Calcul et des Donn\u00e9es (ISCD), France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e9mence","family":"Blachon","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, CNRS, IBPS, Laboratoire de Biologie Computationnelle et Quantitative (LCQB), UMR 7238, Paris 75005, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Oteri","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, CNRS, IBPS, Laboratoire de Biologie Computationnelle et Quantitative (LCQB), UMR 7238, Paris 75005, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2098-5743","authenticated-orcid":false,"given":"Alessandra","family":"Carbone","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, CNRS, IBPS, Laboratoire de Biologie Computationnelle et Quantitative (LCQB), UMR 7238, Paris 75005, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,5,22]]},"reference":[{"key":"2021070812092682500_B1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0079-6107(83)90003-2","article-title":"Structural domains in proteins and their role in the dynamics of protein function","volume":"42","author":"Janin","year":"1983","journal-title":"Prog. 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