{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T14:00:03Z","timestamp":1768485603177,"version":"3.49.0"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"W1","license":[{"start":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T00:00:00Z","timestamp":1621987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","award":["IG 23539"],"award-info":[{"award-number":["IG 23539"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The interaction between RNA and RNA-binding proteins (RBPs) has a key role in the regulation of gene expression, in RNA stability, and in many other biological processes. RBPs accomplish these functions by binding target RNA molecules through specific sequence and structure motifs. The identification of these binding motifs is therefore fundamental to improve our knowledge of the cellular processes and how they are regulated. Here, we present BRIO (BEAM RNA Interaction mOtifs), a new web server designed for the identification of sequence and structure RNA-binding motifs in one or more RNA molecules of interest. BRIO enables the user to scan over 2508 sequence motifs and 2296 secondary structure motifs identified in Homo sapiens and Mus musculus, in three different types of experiments (PAR-CLIP, eCLIP, HITS). The motifs are associated with the binding of 186 RBPs and 69 protein domains. The web server is freely available at http:\/\/brio.bio.uniroma2.it.<\/jats:p>","DOI":"10.1093\/nar\/gkab400","type":"journal-article","created":{"date-parts":[[2021,5,22]],"date-time":"2021-05-22T11:09:13Z","timestamp":1621681753000},"page":"W67-W71","source":"Crossref","is-referenced-by-count":21,"title":["BRIO: a web server for RNA sequence and structure motif scan"],"prefix":"10.1093","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9744-131X","authenticated-orcid":false,"given":"Andrea","family":"Guarracino","sequence":"first","affiliation":[{"name":"Department of Biology, University of Rome \u201cTor Vergata\u201d, Rome, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5308-2765","authenticated-orcid":false,"given":"Gerardo","family":"Pepe","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Rome \u201cTor Vergata\u201d, Rome, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5892-5490","authenticated-orcid":false,"given":"Francesco","family":"Ballesio","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Rome \u201cTor Vergata\u201d, Rome, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3910-0271","authenticated-orcid":false,"given":"Marta","family":"Adinolfi","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Rome \u201cTor Vergata\u201d, Rome, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5129-6065","authenticated-orcid":false,"given":"Marco","family":"Pietrosanto","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Rome \u201cTor Vergata\u201d, Rome, Italy"}]},{"given":"Elisa","family":"Sangiovanni","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Rome \u201cTor Vergata\u201d, Rome, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5918-1841","authenticated-orcid":false,"given":"Ilio","family":"Vitale","sequence":"additional","affiliation":[{"name":"IIGM - Italian Institute for Genomic Medicine, c\/o IRCSS Candiolo, Italy"},{"name":"Candiolo Cancer Institute, FPO - IRCCS, Candiolo, Italy"}]},{"given":"Gabriele","family":"Ausiello","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Rome \u201cTor Vergata\u201d, Rome, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9530-7504","authenticated-orcid":false,"given":"Manuela","family":"Helmer-Citterich","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Rome \u201cTor Vergata\u201d, Rome, Italy"}]}],"member":"286","published-online":{"date-parts":[[2021,5,26]]},"reference":[{"key":"2021070812104530100_B1","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1016\/j.febslet.2008.03.004","article-title":"RNA-binding proteins and post-transcriptional gene regulation","volume":"582","author":"Glisovic","year":"2008","journal-title":"FEBS Lett."},{"key":"2021070812104530100_B2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.molcel.2020.03.011","article-title":"How RNA-binding proteins interact with RNA: molecules and mechanisms","volume":"78","author":"Corley","year":"2020","journal-title":"Mol. 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