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The most important features making lipids different from general metabolites are their various characteristics, including their lipid classes, double bonds, chain lengths, etc. Based on these characteristics, lipid species can be classified into different categories and, more interestingly, exert specific biological functions in a group. In an effort to simplify lipidomic analysis workflows and enhance the exploration of lipid characteristics, we have developed a highly flexible and user-friendly web server called LipidSig. It consists of five sections, namely, Profiling, Differential Expression, Correlation, Network and Machine Learning, and evaluates lipid effects on cellular or disease phenotypes. One of the specialties of LipidSig is the conversion between lipid species and characteristics according to a user-defined characteristics table. This function allows for efficient data mining for both individual lipids and subgroups of characteristics. To expand the server's practical utility, we also provide analyses focusing on fatty acid properties and multiple characteristics. In summary, LipidSig is expected to help users identify significant lipid-related features and to advance the field of lipid biology. The LipidSig webserver is freely available at http:\/\/chenglab.cmu.edu.tw\/lipidsig<\/jats:p>","DOI":"10.1093\/nar\/gkab419","type":"journal-article","created":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T14:51:30Z","timestamp":1620226290000},"page":"W336-W345","source":"Crossref","is-referenced-by-count":69,"title":["LipidSig: a web-based tool for lipidomic data analysis"],"prefix":"10.1093","volume":"49","author":[{"given":"Wen-Jen","family":"Lin","sequence":"first","affiliation":[{"name":"Graduate Institute of Biomedical Science, China Medical University, Taichung 40403, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Chun","family":"Shen","sequence":"additional","affiliation":[{"name":"Research Center for Cancer Biology, China Medical University, Taichung 40403, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiu-Cheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Research Center for Cancer Biology, China Medical University, Taichung 40403, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Chun","family":"Cho","sequence":"additional","affiliation":[{"name":"Research Center for Cancer Biology, China Medical University, Taichung 40403, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Kung","family":"Hsu","sequence":"additional","affiliation":[{"name":"Research Center for Cancer Biology, China Medical University, Taichung 40403, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I-Chen","family":"Lin","sequence":"additional","affiliation":[{"name":"Graduate Institute of Biomedical Science, China Medical University, Taichung 40403, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang-Hsin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan 33302, Taiwan"},{"name":"Department of Radiation Oncology, Chang Gung Memorial Hospital at Linkou, Taoyuan 33302, Taiwan"},{"name":"Institute for Radiological Research, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan 33302, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan-Cheng","family":"Yang","sequence":"additional","affiliation":[{"name":"Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 40403, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Lung","family":"Ma","sequence":"additional","affiliation":[{"name":"Graduate Institute of Biomedical Science, China Medical University, Taichung 40403, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1229-4857","authenticated-orcid":false,"given":"Wei-Chung","family":"Cheng","sequence":"additional","affiliation":[{"name":"Graduate Institute of Biomedical Science, China Medical University, Taichung 40403, Taiwan"},{"name":"Research Center for Cancer Biology, China Medical University, Taichung 40403, Taiwan"},{"name":"The Ph.D. program for Cancer Biology and Drug Discovery, China Medical University and Academia Sinica, Taichung 40403, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,5,28]]},"reference":[{"key":"2021070812112779900_B1","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/nrm.2017.138","article-title":"Understanding the diversity of membrane lipid composition","volume":"19","author":"Harayama","year":"2018","journal-title":"Nat. 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