{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T16:06:13Z","timestamp":1780761973971,"version":"3.54.1"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"W1","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010663","name":"European Research Council","doi-asserted-by":"publisher","award":["716063"],"award-info":[{"award-number":["716063"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Commission H2020","award":["824087"],"award-info":[{"award-number":["824087"]}]},{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","award":["317680"],"award-info":[{"award-number":["317680"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006306","name":"Sigrid Jus\u00e9lius Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006306","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007797","name":"University of Helsinki","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007797","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009067","name":"K. Albin Johanssons Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009067","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Combinatorial therapies that target multiple pathways have shown great promises for treating complex diseases. DrugComb (https:\/\/drugcomb.org\/) is a web-based portal for the deposition and analysis of drug combination screening datasets. Since its first release, DrugComb has received continuous updates on the coverage of data resources, as well as on the functionality of the web server to improve the analysis, visualization and interpretation of drug combination screens. Here, we report significant updates of DrugComb, including: (i) manual curation and harmonization of more comprehensive drug combination and monotherapy screening data, not only for cancers but also for other diseases such as malaria and COVID-19; (ii) enhanced algorithms for assessing the sensitivity and synergy of drug combinations; (iii) network modelling tools to visualize the mechanisms of action of drugs or drug combinations for a given cancer sample and (iv) state-of-the-art machine learning models to predict drug combination sensitivity and synergy. These improvements have been provided with more user-friendly graphical interface and faster database infrastructure, which make DrugComb the most comprehensive web-based resources for the study of drug sensitivities for multiple diseases.<\/jats:p>","DOI":"10.1093\/nar\/gkab438","type":"journal-article","created":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T09:35:49Z","timestamp":1620293749000},"page":"W174-W184","source":"Crossref","is-referenced-by-count":113,"title":["DrugComb update: a more comprehensive drug sensitivity data repository and analysis portal"],"prefix":"10.1093","volume":"49","author":[{"given":"Shuyu","family":"Zheng","sequence":"first","affiliation":[{"name":"Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki FI-00290, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jehad","family":"Aldahdooh","sequence":"additional","affiliation":[{"name":"Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki FI-00290, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tolou","family":"Shadbahr","sequence":"additional","affiliation":[{"name":"Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki FI-00290, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinyin","family":"Wang","sequence":"additional","affiliation":[{"name":"Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki FI-00290, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalal","family":"Aldahdooh","sequence":"additional","affiliation":[{"name":"Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki FI-00290, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Bao","sequence":"additional","affiliation":[{"name":"Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki FI-00290, Finland"},{"name":"Institute for Molecular Medicine Finland, University of Helsinki, Helsinki FI-00290, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki FI-00290, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7480-7710","authenticated-orcid":false,"given":"Jing","family":"Tang","sequence":"additional","affiliation":[{"name":"Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki FI-00290, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,6,1]]},"reference":[{"key":"2021070812135031400_B1","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/s41586-020-1969-6","article-title":"Pan-cancer analysis of whole genomes","volume":"578","author":"Campbell","year":"2020","journal-title":"Nature"},{"key":"2021070812135031400_B2","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1016\/j.cell.2017.11.035","article-title":"On the design of combination cancer therapy","volume":"171","author":"Doroshow","year":"2017","journal-title":"Cell"},{"key":"2021070812135031400_B3","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/978-1-4939-7493-1_17","article-title":"Methods for high-throughput drug combination screening and synergy scoring","volume":"1711","author":"He","year":"2018","journal-title":"Methods Mol. 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