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However, despite such advances, the genetic landscape of human diseases has only marginally been disclosed. Exploiting the present availability of large amounts of biological and phenotypic data, we can use our current understanding of disease genetics to train machine learning models to predict novel genetic factors associated with the disease. To this end, we developed DGLinker, a webserver for the prediction of novel candidate genes for human diseases given a set of known disease genes. DGLinker has a user-friendly interface that allows non-expert users to exploit biomedical information from a wide range of biological and phenotypic databases, and\/or to upload their own data, to generate a knowledge-graph and use machine learning to predict new disease-associated genes. The webserver includes tools to explore and interpret the results and generates publication-ready figures. DGLinker is available at https:\/\/dglinker.rosalind.kcl.ac.uk. The webserver is free and open to all users without the need for registration.<\/jats:p>","DOI":"10.1093\/nar\/gkab449","type":"journal-article","created":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T03:15:43Z","timestamp":1621307743000},"page":"W153-W161","source":"Crossref","is-referenced-by-count":32,"title":["DGLinker: flexible knowledge-graph prediction of disease\u2013gene associations"],"prefix":"10.1093","volume":"49","author":[{"given":"Jiajing","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology & Neuroscience, King's College London,\u00a0SE5 8AF, London, UK"},{"name":"Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 9RT,\u00a0UK"}]},{"given":"Rosalba","family":"Lepore","sequence":"additional","affiliation":[{"name":"BSC-CNS Barcelona Supercomputing Center, Barcelona, 08034,\u00a0Spain"}]},{"given":"Richard J B","family":"Dobson","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology & Neuroscience, King's College London,\u00a0SE5 8AF, London, UK"},{"name":"Health Data Research UK London, University College London, London, WC1E 6BT,\u00a0UK"},{"name":"Institute of Health Informatics, University College London, London, NW1 2DA,\u00a0UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4924-7712","authenticated-orcid":false,"given":"Ammar","family":"Al-Chalabi","sequence":"additional","affiliation":[{"name":"Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 9RT,\u00a0UK"},{"name":"King\u2032s College Hospital, Bessemer Road, Denmark Hill, London, SE5 9RS, UK"}]},{"given":"Daniel","family":"M.\u00a0Bean","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology & Neuroscience, King's College London,\u00a0SE5 8AF, London, UK"},{"name":"Health Data Research UK London, University College London, London, WC1E 6BT,\u00a0UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5280-5017","authenticated-orcid":false,"given":"Alfredo","family":"Iacoangeli","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology & Neuroscience, King's College London,\u00a0SE5 8AF, London, UK"},{"name":"Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 9RT,\u00a0UK"},{"name":"National Institute for Health Research Biomedical Research Centre and Dementia Unit at South London and Maudsley NHS Foundation Trust and King's College London, London, SE5 8AF,\u00a0UK"}]}],"member":"286","published-online":{"date-parts":[[2021,6,14]]},"reference":[{"key":"2021071005105669700_B1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1515\/jib-2018-0069","article-title":"A survey of gene prioritization tools for mendelian and complex human diseases","volume":"16","author":"Zolotareva","year":"2019","journal-title":"J. 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