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With increasing attention being paid to virus-mediated pathogenesis and the development of many useful technologies to identify virus mutations (VMs) and viral integration sites (VISs), much research on these topics is available in PubMed. However, knowledge of VMs and VISs is widely scattered in numerous published papers which lack standardization, integration and curation. To address these challenges, we built a pilot database of human disease-related Virus Mutations, Integration sites and Cis-effects (ViMIC), which specializes in three features: virus mutation sites, viral integration sites and target genes. In total, the ViMIC provides information on 31 712 VMs entries, 105 624 VISs, 16 310 viral target genes and 1 110 015 virus sequences of eight viruses in 77 human diseases obtained from the public domain. Furthermore, in ViMIC users are allowed to explore the cis-effects of virus-host interactions by surveying 78 histone modifications, binding of 1358 transcription regulators\u00a0and chromatin accessibility on these VISs. We believe ViMIC will become a valuable resource for the virus research community. The database is available at http:\/\/bmtongji.cn\/ViMIC\/index.php.<\/jats:p>","DOI":"10.1093\/nar\/gkab779","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T07:37:07Z","timestamp":1631086627000},"page":"D918-D927","source":"Crossref","is-referenced-by-count":30,"title":["ViMIC: a database of human disease-related virus mutations, integration sites and\n                    <i>cis<\/i>\n                    -effects"],"prefix":"10.1093","volume":"50","author":[{"given":"Ying","family":"Wang","sequence":"first","affiliation":[{"name":"Research Center for Translational Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai\u00a0200092, China"},{"name":"Department of Laboratory Medicine, Shanghai Eastern Hepatobiliary Surgery Hospital, Shanghai\u00a0200438, China"}]},{"given":"Yuantao","family":"Tong","sequence":"additional","affiliation":[{"name":"Research Center for Translational Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai\u00a0200092, China"}]},{"given":"Zeyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Research Center for Translational Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai\u00a0200092, China"}]},{"given":"Rongbin","family":"Zheng","sequence":"additional","affiliation":[{"name":"Research Center for Translational Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai\u00a0200092, China"}]},{"given":"Danqi","family":"Huang","sequence":"additional","affiliation":[{"name":"Research Center for Translational Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai\u00a0200092, China"}]},{"given":"Jinxuan","family":"Yang","sequence":"additional","affiliation":[{"name":"Research Center for Translational Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai\u00a0200092, China"}]},{"given":"Hui","family":"Zong","sequence":"additional","affiliation":[{"name":"Research Center for Translational Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai\u00a0200092, China"}]},{"given":"Fanglin","family":"Tan","sequence":"additional","affiliation":[{"name":"Research Center for Translational Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai\u00a0200092, China"}]},{"given":"Yujia","family":"Xie","sequence":"additional","affiliation":[{"name":"Research Center for Translational Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai\u00a0200092, China"}]},{"given":"Honglian","family":"Huang","sequence":"additional","affiliation":[{"name":"Research Center for Translational Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai\u00a0200092, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1562-0045","authenticated-orcid":false,"given":"Xiaoyan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Research Center for Translational Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai\u00a0200092, China"}]}],"member":"286","published-online":{"date-parts":[[2021,9,9]]},"reference":[{"key":"2022010507351961100_B1","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.3390\/cancers6042155","article-title":"Viral carcinogenesis: factors inducing DNA damage and virus integration","volume":"6","author":"Chen","year":"2014","journal-title":"Cancers (Basel)"},{"key":"2022010507351961100_B2","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/path.4476","article-title":"Viruses and disease: emerging concepts for prevention, diagnosis and treatment","volume":"235","author":"Herrington","year":"2015","journal-title":"J. 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