{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T04:06:16Z","timestamp":1776139576827,"version":"3.50.1"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T00:00:00Z","timestamp":1631145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Tou-Yan Innovation Team Program of the Heilongjiang Province","award":["2019-15"],"award-info":[{"award-number":["2019-15"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61871160"],"award-info":[{"award-number":["61871160"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62172130"],"award-info":[{"award-number":["62172130"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Young Innovative Talents in Colleges and Universities of Heilongjiang Province","award":["2018-69"],"award-info":[{"award-number":["2018-69"]}]},{"name":"Heilongjiang Postdoctoral Fund","award":["LBH-Q20030"],"award-info":[{"award-number":["LBH-Q20030"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>gutMGene (http:\/\/bio-annotation.cn\/gutmgene), a manually curated database, aims at providing a comprehensive resource of target genes of gut microbes and microbial metabolites in humans and mice. Metagenomic sequencing of fecal samples has identified 3.3\u00a0\u00d7\u00a0106 non-redundant microbial genes from up to 1500 different species. One of the contributions of gut microbiota to host biology is the circulating pool of bacterially derived small-molecule metabolites. It has been estimated that 10% of metabolites found in mammalian blood are derived from the gut microbiota, where they can produce systemic effects on the host through activating or inhibiting gene expression. The current version of gutMGene documents 1331 curated relationships between 332 gut microbes, 207 microbial metabolites and 223 genes in humans, and 2349 curated relationships between 209 gut microbes, 149 microbial metabolites and 544 genes in mice. Each entry in the gutMGene contains detailed information on a relationship between gut microbe, microbial metabolite and target gene, a brief description of the relationship, experiment technology and platform, literature reference and so on. gutMGene provides a user-friendly interface to browse and\u00a0retrieve each entry using gut microbes, disorders and intervention measures. It also offers the option to download all the entries and submit new experimentally validated associations.<\/jats:p>","DOI":"10.1093\/nar\/gkab786","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T11:37:07Z","timestamp":1631101027000},"page":"D795-D800","source":"Crossref","is-referenced-by-count":157,"title":["gutMGene: a comprehensive database for target genes of gut microbes and microbial metabolites"],"prefix":"10.1093","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6665-6710","authenticated-orcid":false,"given":"Liang","family":"Cheng","sequence":"first","affiliation":[{"name":"NHC and CAMS Key Laboratory of Molecular Probe and Targeted Theranostics, Harbin Medical University, Harbin\u00a0150028, Heilongjiang, China"},{"name":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin\u00a0150081, Heilongjiang, China"}]},{"given":"Changlu","family":"Qi","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin\u00a0150081, Heilongjiang, China"}]},{"given":"Haixiu","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin\u00a0150081, Heilongjiang, China"}]},{"given":"Minke","family":"Lu","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin\u00a0150081, Heilongjiang, China"}]},{"given":"Yiting","family":"Cai","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin\u00a0150081, Heilongjiang, China"}]},{"given":"Tongze","family":"Fu","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin\u00a0150081, Heilongjiang, China"}]},{"given":"Jialiang","family":"Ren","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin\u00a0150081, Heilongjiang, China"}]},{"given":"Qu","family":"Jin","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin\u00a0150081, Heilongjiang, China"}]},{"given":"Xue","family":"Zhang","sequence":"additional","affiliation":[{"name":"NHC and CAMS Key Laboratory of Molecular Probe and Targeted Theranostics, Harbin Medical University, Harbin\u00a0150028, Heilongjiang, China"},{"name":"McKusick\u2013Zhang Center for Genetic Medicine,\u00a0Peking Union Medical College, Beijing\u00a0100005, China"}]}],"member":"286","published-online":{"date-parts":[[2021,9,9]]},"reference":[{"key":"2022010507332680600_B1","doi-asserted-by":"crossref","first-page":"e1002533","DOI":"10.1371\/journal.pbio.1002533","article-title":"Revised estimates for the number of human and bacteria cells in the body","volume":"14","author":"Sender","year":"2016","journal-title":"PLoS Biol."},{"key":"2022010507332680600_B2","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1042\/BCJ20160510","article-title":"Introduction to the human gut microbiota","volume":"474","author":"Thursby","year":"2017","journal-title":"Biochem. 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