{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T12:55:53Z","timestamp":1782564953370,"version":"3.54.5"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2021,9,11]],"date-time":"2021-09-11T00:00:00Z","timestamp":1631318400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61673323"],"award-info":[{"award-number":["61673323"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Alternative polyadenylation (APA) is a widespread regulatory mechanism of transcript diversification in eukaryotes, which is increasingly recognized as an important layer for eukaryotic gene expression. Recent studies based on single-cell RNA-seq (scRNA-seq) have revealed cell-to-cell heterogeneity in APA usage and APA dynamics across different cell types in various tissues, biological processes and diseases. However, currently available APA databases were all collected from bulk 3\u2032-seq and\/or RNA-seq data, and no existing database has provided APA information at single-cell resolution. Here, we present a user-friendly database called scAPAdb (http:\/\/www.bmibig.cn\/scAPAdb), which provides a comprehensive and manually curated atlas of poly(A) sites, APA events and poly(A) signals at the single-cell level. Currently, scAPAdb collects APA information from\u00a0&amp;gt;\u00a0360 scRNA-seq experiments, covering six species including human, mouse and several other plant species. scAPAdb also provides batch download of data, and users can query the database through a variety of keywords such as gene identifier, gene function and accession number. scAPAdb would be a valuable and extendable resource for the study of cell-to-cell heterogeneity in APA isoform usages and APA-mediated gene regulation at the single-cell level under diverse cell types, tissues and species.<\/jats:p>","DOI":"10.1093\/nar\/gkab795","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T11:37:07Z","timestamp":1631101027000},"page":"D365-D370","source":"Crossref","is-referenced-by-count":24,"title":["scAPAdb: a comprehensive database of alternative polyadenylation at single-cell resolution"],"prefix":"10.1093","volume":"50","author":[{"given":"Sheng","family":"Zhu","sequence":"first","affiliation":[{"name":"Pasteurien College, Soochow University, Suzhou, Jiangsu 215000, China"},{"name":"Department of Automation, Xiamen University, Xiamen, Fujian 361005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiwei","family":"Lian","sequence":"additional","affiliation":[{"name":"Department of Automation, Xiamen University, Xiamen, Fujian 361005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Automation, Xiamen University, Xiamen, Fujian 361005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Automation, Xiamen University, Xiamen, Fujian 361005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Automation, Xiamen University, Xiamen, Fujian 361005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoli","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Automation, Xiamen University, Xiamen, Fujian 361005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0356-7785","authenticated-orcid":false,"given":"Xiaohui","family":"Wu","sequence":"additional","affiliation":[{"name":"Pasteurien College, Soochow University, Suzhou, Jiangsu 215000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,9,11]]},"reference":[{"key":"2022010507391072100_B1","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/nrm.2016.116","article-title":"Alternative polyadenylation of mRNA precursors","volume":"18","author":"Tian","year":"2017","journal-title":"Nat. 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