{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T17:21:07Z","timestamp":1771953667423,"version":"3.50.1"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T00:00:00Z","timestamp":1631750400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFB0204403"],"award-info":[{"award-number":["2018YFB0204403"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Guangdong Basic and Applied Basic Research Foundation, China","award":["2020A1515110528"],"award-info":[{"award-number":["2020A1515110528"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32100513"],"award-info":[{"award-number":["32100513"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2021M693302"],"award-info":[{"award-number":["2021M693302"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Strategic Priority CAS Project","award":["XDB38000000"],"award-info":[{"award-number":["XDB38000000"]}]},{"name":"Shenzhen Basic Research Fund","award":["RCYX2020071411473419"],"award-info":[{"award-number":["RCYX2020071411473419"]}]},{"name":"Shenzhen Basic Research Fund","award":["KQTD20200820113106007"],"award-info":[{"award-number":["KQTD20200820113106007"]}]},{"name":"Shenzhen Basic Research Fund","award":["JSGG20201102163800001"],"award-info":[{"award-number":["JSGG20201102163800001"]}]},{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzhen","doi-asserted-by":"publisher","award":["SZSM201911016"],"award-info":[{"award-number":["SZSM201911016"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Many circRNA transcriptome data were deposited in public resources, but these data show great heterogeneity. Researchers without bioinformatics skills have difficulty in investigating these invaluable data or their own data. Here, we specifically designed circMine (http:\/\/hpcc.siat.ac.cn\/circmine and http:\/\/www.biomedical-web.com\/circmine\/) that provides 1\u00a0821\u00a0448 entries formed by 136\u00a0871 circRNAs, 87 diseases and 120 circRNA transcriptome datasets of 1107 samples across 31 human body sites. circMine further provides 13 online analytical functions to comprehensively investigate these datasets to evaluate the clinical and biological significance of circRNA. To improve the data applicability, each dataset was standardized and annotated with relevant clinical information. All of the 13 analytic functions allow users to group samples based on their clinical data and assign different parameters for different analyses, and enable them to perform these analyses using their own circRNA transcriptomes. Moreover, three additional tools were developed in circMine to systematically discover the circRNA\u2013miRNA interaction and circRNA translatability. For example, we systematically discovered five potential translatable circRNAs associated with prostate cancer progression using circMine. In summary, circMine provides user-friendly web interfaces to browse, search, analyze and download data freely, and submit new data for further integration, and it can be an important resource to discover significant circRNA in different diseases.<\/jats:p>","DOI":"10.1093\/nar\/gkab809","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T11:37:07Z","timestamp":1631101027000},"page":"D83-D92","source":"Crossref","is-referenced-by-count":48,"title":["circMine: a comprehensive database to integrate, analyze and visualize human disease\u2013related circRNA transcriptome"],"prefix":"10.1093","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0454-6935","authenticated-orcid":false,"given":"Wenliang","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pediatrics, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong 518053, China"},{"name":"Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong 518055, China"},{"name":"Department of Bioinformatics, Outstanding Biotechnology Co., Ltd.-Shenzhen, Shenzhen 518053, China"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong 518055, China"},{"name":"Department of Gastroenterology and Hepatology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong 518053, China"},{"name":"Experimental Training Management Center, Jilin Business and Technology, Jilin Province 130507, China"}]},{"given":"Zhuochao","family":"Min","sequence":"additional","affiliation":[{"name":"School of Information and Software Engineering, University of Electronic Science and Technology of China, Chengdu 610054, China"}]},{"given":"Guodong","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Colorectal and\u00a0Stomach Cancer Surgery, Jilin Cancer Hospital, Changchun, Jilin 130000, China"}]},{"given":"Jing","family":"Mo","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics, Outstanding Biotechnology Co., Ltd.-Shenzhen, Shenzhen 518053, China"}]},{"given":"Zhen","family":"Ju","sequence":"additional","affiliation":[{"name":"Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong 518055, China"},{"name":"Center for High Performance Computing, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong 518055, China"},{"name":"CAS Key Laboratory of Health Informatics, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong 518055, China"}]},{"given":"Binghui","family":"Zeng","sequence":"additional","affiliation":[{"name":"Hospital of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou 510055, China"},{"name":"Department of Bioinformatics, Outstanding Biotechnology Co., Ltd.-Shenzhen, Shenzhen 518053, China"}]},{"given":"Wen","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics, Outstanding Biotechnology Co., Ltd.-Shenzhen, Shenzhen 518053, China"},{"name":"Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Institute of Zoology, Guangdong Academy of Sciences, Guangzhou 510260, China"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong 518055, China"}]},{"given":"Jianliang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong 518053, China"}]},{"given":"Qianshen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong 518053, China"}]},{"given":"Hanguang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong 518053, China"}]},{"given":"Chunxia","family":"Zeng","sequence":"additional","affiliation":[{"name":"Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong 518055, China"},{"name":"Center for High Performance Computing, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong 518055, China"},{"name":"CAS Key Laboratory of Health Informatics, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong 518055, China"}]},{"given":"Yanjie","family":"Wei","sequence":"additional","affiliation":[{"name":"Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong 518055, China"},{"name":"Center for High Performance Computing, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong 518055, China"},{"name":"CAS Key Laboratory of Health Informatics, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong 518055, China"}]},{"given":"Godfrey\u00a0Chi-Fung","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong 518053, China"},{"name":"Department of Pediatrics and Adolescent Medicine, LKS Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong 999077, China"}]}],"member":"286","published-online":{"date-parts":[[2021,9,16]]},"reference":[{"key":"2022010507324220900_B1","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/s41576-019-0158-7","article-title":"The biogenesis, biology and characterization of circular RNAs","volume":"20","author":"Kristensen","year":"2019","journal-title":"Nat. Rev. Genet."},{"key":"2022010507324220900_B2","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/s41580-020-0243-y","article-title":"The expanding regulatory mechanisms and cellular functions of circular RNAs","volume":"21","author":"Chen","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2022010507324220900_B3","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1101\/gr.202895.115","article-title":"Diverse alternative back-splicing and alternative splicing landscape of circular RNAs","volume":"26","author":"Zhang","year":"2016","journal-title":"Genome Res."},{"key":"2022010507324220900_B4","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1093\/bib\/bbx014","article-title":"Circular RNA identification based on multiple seed matching","volume":"19","author":"Gao","year":"2018","journal-title":"Brief. Bioinform."},{"key":"2022010507324220900_B5","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1093\/bioinformatics\/btv656","article-title":"Specific identification and quantification of circular RNAs from sequencing data","volume":"32","author":"Cheng","year":"2016","journal-title":"Bioinformatics"},{"key":"2022010507324220900_B6","first-page":"S1046","article-title":"CIRCexplorer pipelines for circRNA annotation and quantification from non-polyadenylated RNA-seq datasets","volume":"21","author":"Ma","year":"2021","journal-title":"Methods"},{"key":"2022010507324220900_B7","doi-asserted-by":"crossref","first-page":"D925","DOI":"10.1093\/nar\/gkx863","article-title":"CSCD: a database for cancer-specific circular RNAs","volume":"46","author":"Xia","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"2022010507324220900_B8","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s13073-019-0663-5","article-title":"Comprehensive characterization of circular RNAs in \u223c 1000 human cancer cell lines","volume":"11","author":"Ruan","year":"2019","journal-title":"Genome Med"},{"key":"2022010507324220900_B9","first-page":"984","article-title":"Comprehensive characterization of tissue-specific circular RNAs in the human and mouse genomes","volume":"18","author":"Xia","year":"2017","journal-title":"Brief. Bioinform."},{"key":"2022010507324220900_B10","doi-asserted-by":"crossref","first-page":"D106","DOI":"10.1093\/nar\/gkx891","article-title":"exoRBase: a database of circRNA, lncRNA and mRNA in human blood exosomes","volume":"46","author":"Li","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"2022010507324220900_B11","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1080\/15476286.2015.1128065","article-title":"CircInteractome: a web tool for exploring circular RNAs and their interacting proteins and microRNAs","volume":"13","author":"Dudekula","year":"2016","journal-title":"Rna Biol"},{"key":"2022010507324220900_B12","doi-asserted-by":"crossref","first-page":"D209","DOI":"10.1093\/nar\/gkv940","article-title":"CircNet: a database of circular RNAs derived from transcriptome sequencing data","volume":"44","author":"Liu","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"2022010507324220900_B13","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s13059-021-02300-7","article-title":"riboCIRC: a comprehensive database of translatable circRNAs","volume":"22","author":"Li","year":"2021","journal-title":"Genome Biol."},{"key":"2022010507324220900_B14","doi-asserted-by":"crossref","first-page":"D236","DOI":"10.1093\/nar\/gkaa823","article-title":"TransCirc: an interactive database for translatable circular RNAs based on multi-omics evidence","volume":"49","author":"Huang","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"2022010507324220900_B15","doi-asserted-by":"crossref","first-page":"34985","DOI":"10.1038\/srep34985","article-title":"circRNADb: a comprehensive database for human circular RNAs with protein-coding annotations","volume":"6","author":"Chen","year":"2016","journal-title":"Sci. Rep."},{"key":"2022010507324220900_B16","doi-asserted-by":"crossref","first-page":"11018","DOI":"10.1038\/s41598-018-29360-3","article-title":"Circ2Disease: a manually curated database of experimentally validated circRNAs in human disease","volume":"8","author":"Yao","year":"2018","journal-title":"Sci. Rep."},{"key":"2022010507324220900_B17","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/s41419-018-0503-3","article-title":"circRNA disease: a manually curated database of experimentally supported circRNA-disease associations","volume":"9","author":"Zhao","year":"2018","journal-title":"Cell Death Dis."},{"key":"2022010507324220900_B18","doi-asserted-by":"crossref","first-page":"166727","DOI":"10.1016\/j.jmb.2020.166727","article-title":"ncRNAVar: a manually curated database for identification of noncoding RNA variants associated with human diseases","volume":"433","author":"Zhang","year":"2021","journal-title":"J. Mol. Biol."},{"key":"2022010507324220900_B19","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1080\/15476286.2020.1737441","article-title":"ncRPheno: a comprehensive database platform for identification and validation of disease related noncoding RNAs","volume":"17","author":"Zhang","year":"2020","journal-title":"RNA Biol."},{"key":"2022010507324220900_B20","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1261\/rna.043687.113","article-title":"circBase: a database for circular RNAs","volume":"20","author":"Glazar","year":"2014","journal-title":"RNA"},{"key":"2022010507324220900_B21","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1080\/15476286.2019.1600395","article-title":"Circbank: a comprehensive database for circRNA with standard nomenclature","volume":"16","author":"Liu","year":"2019","journal-title":"RNA Biol"},{"key":"2022010507324220900_B22","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s13059-020-02018-y","article-title":"CircAtlas: an integrated resource of one million highly accurate circular RNAs from 1070 vertebrate transcriptomes","volume":"21","author":"Wu","year":"2020","journal-title":"Genome Biol."},{"key":"2022010507324220900_B23","doi-asserted-by":"crossref","first-page":"D10","DOI":"10.1093\/nar\/gkaa892","article-title":"Database resources of the National Center for Biotechnology Information","volume":"49","author":"Sayers","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"2022010507324220900_B24","doi-asserted-by":"crossref","first-page":"D991","DOI":"10.1093\/nar\/gks1193","article-title":"NCBI GEO: archive for functional genomics data sets\u2013update","volume":"41","author":"Barrett","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"2022010507324220900_B25","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/j.cell.2006.07.031","article-title":"A pattern-based method for the identification of MicroRNA binding sites and their corresponding heteroduplexes","volume":"126","author":"Miranda","year":"2006","journal-title":"Cell"},{"key":"2022010507324220900_B26","doi-asserted-by":"crossref","first-page":"D155","DOI":"10.1093\/nar\/gky1141","article-title":"miRBase: from microRNA sequences to function","volume":"47","author":"Kozomara","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"2022010507324220900_B27","doi-asserted-by":"crossref","first-page":"W29","DOI":"10.1093\/nar\/gkt282","article-title":"BLAST: a more efficient report with usability improvements","volume":"41","author":"Boratyn","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"2022010507324220900_B28","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.gpb.2020.03.001","article-title":"IRESbase: a comprehensive database of experimentally validated internal ribosome entry sites","volume":"18","author":"Zhao","year":"2020","journal-title":"Genomics Proteomics Bioinformatics"},{"key":"2022010507324220900_B29","doi-asserted-by":"crossref","first-page":"3387","DOI":"10.1093\/bioinformatics\/btx431","article-title":"DeepLoc: prediction of protein subcellular localization using deep learning","volume":"33","author":"Almagro","year":"2017","journal-title":"Bioinformatics"},{"key":"2022010507324220900_B30","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1093\/bib\/bbs038","article-title":"The UCSC genome browser and associated tools","volume":"14","author":"Kuhn","year":"2013","journal-title":"Brief. Bioinform."},{"key":"2022010507324220900_B31","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1038\/s41388-018-0602-8","article-title":"Dysregulation of p53-RBM25-mediated circAMOTL1L biogenesis contributes to prostate cancer progression through the circAMOTL1L-miR-193a-5p-Pcdha pathway","volume":"38","author":"Yang","year":"2019","journal-title":"Oncogene"},{"key":"2022010507324220900_B32","doi-asserted-by":"crossref","first-page":"3666","DOI":"10.1038\/s41388-020-1243-2","article-title":"Lipogenic signalling modulates prostate cancer cell adhesion and migration via modification of Rho GTPases","volume":"39","author":"De\u00a0Piano","year":"2020","journal-title":"Oncogene"},{"key":"2022010507324220900_B33","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1002\/ijc.33332","article-title":"Thyroid and androgen receptor signaling are antagonized by mu-Crystallin in prostate cancer","volume":"148","author":"Aksoy","year":"2021","journal-title":"Int. J. Cancer"},{"key":"2022010507324220900_B34","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/nrurol.2012.19","article-title":"Proteoglycans in prostate cancer","volume":"9","author":"Edwards","year":"2012","journal-title":"Nat Rev Urol"},{"key":"2022010507324220900_B35","doi-asserted-by":"crossref","first-page":"R195","DOI":"10.1530\/ERC-19-0009","article-title":"ErbB-2 signaling in advanced prostate cancer progression and potential therapy","volume":"26","author":"Miller","year":"2019","journal-title":"Endocr. Relat. Cancer"},{"key":"2022010507324220900_B36","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1038\/s41419-019-2028-9","article-title":"Circular RNA circ0005276 promotes the proliferation and migration of prostate cancer cells by interacting with FUS to transcriptionally activate XIAP","volume":"10","author":"Feng","year":"2019","journal-title":"Cell Death Dis."},{"key":"2022010507324220900_B37","doi-asserted-by":"crossref","first-page":"892","DOI":"10.3389\/fgene.2020.00892","article-title":"Identification of prostate cancer-related circular RNA through bioinformatics analysis","volume":"11","author":"Wu","year":"2020","journal-title":"Front. Genet."},{"key":"2022010507324220900_B38","doi-asserted-by":"crossref","first-page":"599494","DOI":"10.3389\/fcell.2020.599494","article-title":"An eight-circRNA assessment model for predicting biochemical recurrence in prostate cancer","volume":"8","author":"Wang","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"2022010507324220900_B39","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.cell.2018.12.021","article-title":"The landscape of circular RNA in cancer","volume":"176","author":"Vo","year":"2019","journal-title":"Cell"},{"key":"2022010507324220900_B40","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.gpb.2018.08.001","article-title":"CIRCpedia v2: an updated database for comprehensive circular RNA annotation and expression comparison","volume":"16","author":"Dong","year":"2018","journal-title":"Genomics Proteomics Bioinformatics"},{"key":"2022010507324220900_B41","first-page":"1310","article-title":"CircView: a visualization and exploration tool for circular RNAs","volume":"19","author":"Feng","year":"2018","journal-title":"Brief. Bioinform."},{"key":"2022010507324220900_B42","doi-asserted-by":"crossref","first-page":"D941","DOI":"10.1093\/nar\/gky1015","article-title":"COSMIC: the catalogue of somatic mutations in cancer","volume":"47","author":"Tate","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"2022010507324220900_B43","doi-asserted-by":"crossref","first-page":"D1005","DOI":"10.1093\/nar\/gky1120","article-title":"The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019","volume":"47","author":"Buniello","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"2022010507324220900_B44","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1038\/ng.2764","article-title":"The cancer genome atlas pan-cancer analysis project","volume":"45","author":"Weinstein","year":"2013","journal-title":"Nat. Genet."},{"key":"2022010507324220900_B45","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/s41587-019-0055-9","article-title":"The international cancer genome consortium data portal","volume":"37","author":"Zhang","year":"2019","journal-title":"Nat. Biotechnol."}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/nar\/article-pdf\/50\/D1\/D83\/42057772\/gkab809.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/nar\/article-pdf\/50\/D1\/D83\/42057772\/gkab809.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T07:50:55Z","timestamp":1641369055000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article\/50\/D1\/D83\/6371375"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,16]]},"references-count":45,"journal-issue":{"issue":"D1","published-online":{"date-parts":[[2021,9,16]]},"published-print":{"date-parts":[[2022,1,7]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gkab809","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,1,7]]},"published":{"date-parts":[[2021,9,16]]}}}