{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T04:31:09Z","timestamp":1768451469887,"version":"3.49.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T00:00:00Z","timestamp":1631836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000051","name":"National Human Genome Research Institute","doi-asserted-by":"publisher","award":["R01HG011633"],"award-info":[{"award-number":["R01HG011633"]}],"id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute of Aging","award":["R03AG070417"],"award-info":[{"award-number":["R03AG070417"]}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA262623"],"award-info":[{"award-number":["R01CA262623"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004917","name":"Cancer Prevention Research Institute of Texas","doi-asserted-by":"publisher","award":["RR150085"],"award-info":[{"award-number":["RR150085"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004917","name":"Cancer Prevention Research Institute of Texas","doi-asserted-by":"publisher","award":["RP190570"],"award-info":[{"award-number":["RP190570"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Texas A&M Institute of Biosciences and Technology"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Altered A-to-I RNA editing has been widely observed in many human cancers and some editing sites are associated with drug sensitivity, implicating its therapeutic potential. Increasing evidence has demonstrated that a quantitative trait loci mapping approach is effective to understanding the genetic basis of RNA editing. We systematically performed RNA editing quantitative trait loci (edQTL) analysis in 33 human cancer types for &amp;gt;10 000 cancer samples and identified 320 029 edQTLs. We also identified 1688 ed-QTLs associated with patient overall survival and 4672 ed-QTLs associated with GWAS risk loci. Furthermore, we demonstrated the associations between RNA editing and &amp;gt;1000 anti-cancer drug response with \u223c3.5 million significant associations. We developed GPEdit (https:\/\/hanlab.uth.edu\/GPEdit\/) to facilitate a global map of the genetic and pharmacogenomic landscape of RNA editing. GPEdit is a user-friendly and comprehensive database that provides an opportunity for a better understanding of the genetic impact and the effects on drug response of RNA editing in cancers.<\/jats:p>","DOI":"10.1093\/nar\/gkab810","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T11:37:07Z","timestamp":1631101027000},"page":"D1231-D1237","source":"Crossref","is-referenced-by-count":20,"title":["GPEdit: the genetic and pharmacogenomic landscape of A-to-I RNA editing in cancers"],"prefix":"10.1093","volume":"50","author":[{"given":"Hang","family":"Ruan","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX\u00a077030, USA"}]},{"given":"Qiang","family":"Li","sequence":"additional","affiliation":[{"name":"Center for Epigenetics and Disease Prevention, Institute of Biosciences and Technology, Texas A&M University, Houston, TX\u00a077030, USA"}]},{"given":"Yuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Center for Epigenetics and Disease Prevention, Institute of Biosciences and Technology, Texas A&M University, Houston, TX\u00a077030, USA"}]},{"given":"Yaoming","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX\u00a077030, USA"}]},{"given":"Charles","family":"Lussier","sequence":"additional","affiliation":[{"name":"Center for Epigenetics and Disease Prevention, Institute of Biosciences and Technology, Texas A&M University, Houston, TX\u00a077030, USA"},{"name":"Department of Computer Science and Statistics, Rice University, Houston, TX\u00a077030, USA"}]},{"given":"Lixia","family":"Diao","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX\u00a077030, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7380-2640","authenticated-orcid":false,"given":"Leng","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX\u00a077030, USA"},{"name":"Center for Epigenetics and Disease Prevention, Institute of Biosciences and Technology, Texas A&M University, Houston, TX\u00a077030, USA"},{"name":"Department of Translational Medical Sciences, College of Medicine, Texas A&M University, Houston, TX\u00a077030, USA"}]}],"member":"286","published-online":{"date-parts":[[2021,9,17]]},"reference":[{"key":"2022010507313816000_B1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1186\/s13059-017-1315-y","article-title":"Massive A-to-I RNA editing is common across the Metazoa and correlates with dsRNA abundance","volume":"18","author":"Porath","year":"2017","journal-title":"Genome Biol."},{"key":"2022010507313816000_B2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ebiom.2017.12.017","article-title":"Regulatory RNA editing sites in cancer: prediction and beyond","volume":"27","author":"Ruan","year":"2018","journal-title":"EBioMedicine"},{"key":"2022010507313816000_B3","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1038\/nn.4337","article-title":"Dynamic regulation of RNA editing in human brain development and disease","volume":"19","author":"Hwang","year":"2016","journal-title":"Nat. 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