{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T01:38:10Z","timestamp":1775266690917,"version":"3.50.1"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2021,9,22]],"date-time":"2021-09-22T00:00:00Z","timestamp":1632268800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870129"],"award-info":[{"award-number":["81870129"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170170"],"award-info":[{"award-number":["82170170"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2019YFA0904303"],"award-info":[{"award-number":["2019YFA0904303"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Major Projects of Technological Innovation in Hubei Province","award":["2019AEA170"],"award-info":[{"award-number":["2019AEA170"]}]},{"name":"Frontier Projects of Wuhan for Application Foundation","award":["2019010701011381"],"award-info":[{"award-number":["2019010701011381"]}]},{"name":"Translational Medicine and Interdisciplinary Research Joint Fund of Zhongnan Hospital of Wuhan University","award":["ZNJC201919"],"award-info":[{"award-number":["ZNJC201919"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The significant function of circRNAs in cancer was recognized in recent work, so a well-organized resource is required for characterizing the interactions between circRNAs and other functional molecules (such as microRNA and RNA-binding protein) in cancer. We previously developed cancer-specific circRNA database (CSCD), a comprehensive database for cancer-specific circRNAs, which is widely used in circRNA research. Here, we updated CSCD to CSCD2 (http:\/\/geneyun.net\/CSCD2 or http:\/\/gb.whu.edu.cn\/CSCD2), which includes significantly more cancer-specific circRNAs identified from a large number of human cancer and normal tissues\/cell lines. CSCD2 contains &amp;gt;1000 samples (825 tissues and 288 cell lines) and identifies a large number of circRNAs: 1\u00a0013\u00a0461 cancer-specific circRNAs, 1\u00a0533\u00a0704 circRNAs from only normal samples and 354\u00a0422 circRNAs from both cancer and normal samples. In addition, CSCD2 predicts potential miRNA\u2013circRNA and RBP\u2013circRNA interactions using binding motifs from &amp;gt;200 RBPs and 2000 microRNAs. Furthermore, the potential full-length and open reading frame sequence of these circRNAs were also predicted. Collectively, CSCD2 provides a significantly enhanced resource for exploring the function and regulation of circRNAs in cancer.<\/jats:p>","DOI":"10.1093\/nar\/gkab830","type":"journal-article","created":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T12:29:06Z","timestamp":1631190546000},"page":"D1179-D1183","source":"Crossref","is-referenced-by-count":68,"title":["CSCD2: an integrated interactional database of cancer-specific circular RNAs"],"prefix":"10.1093","volume":"50","author":[{"given":"Jing","family":"Feng","sequence":"first","affiliation":[{"name":"School of Computer Science, Wuhan University, Wuhan430072, China"}]},{"given":"Wenbo","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Wuhan University, Wuhan430071, China"}]},{"given":"Xin","family":"Dong","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Wuhan University, Wuhan430071, China"}]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Wuhan University, Wuhan430071, China"}]},{"given":"Xiangfei","family":"Mei","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Wuhan University, Wuhan430071, China"}]},{"given":"Jin","family":"Deng","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Wuhan University, Wuhan430071, China"}]},{"given":"Siqi","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Wuhan University, Wuhan430071, China"}]},{"given":"Chenjian","family":"Zhuo","sequence":"additional","affiliation":[{"name":"College of Biomedicine and Health, Huazhong Agricultural University, Wuhan430070, China"}]},{"given":"Xiaoyu","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Wuhan University, Wuhan430071, China"}]},{"given":"Lin","family":"Shao","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Wuhan University, Wuhan430071, China"}]},{"given":"Rongyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Biomedicine and Health, Huazhong Agricultural University, Wuhan430070, China"}]},{"given":"Jing","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Wuhan University, Wuhan430071, China"}]},{"given":"Ronghui","family":"Ma","sequence":"additional","affiliation":[{"name":"College of Biomedicine and Health, Huazhong Agricultural University, Wuhan430070, China"}]},{"given":"Juan","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Computer Science, Wuhan University, Wuhan430072, China"}]},{"given":"Feng","family":"Li","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Wuhan University, Wuhan430071, China"}]},{"given":"Ying","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Wuhan University, Wuhan430071, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7380-2640","authenticated-orcid":false,"given":"Leng","family":"Han","sequence":"additional","affiliation":[{"name":"Center for Epigenetics and Disease Prevention, Institute of Biosciences and Technology, Texas A&M University, Houston, TX77030, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4868-331X","authenticated-orcid":false,"given":"Chunjiang","family":"He","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Wuhan University, Wuhan430071, China"},{"name":"College of Biomedicine and Health, Huazhong Agricultural University, Wuhan430070, China"}]}],"member":"286","published-online":{"date-parts":[[2021,9,22]]},"reference":[{"key":"2022010507351306200_B1","doi-asserted-by":"crossref","first-page":"e90859","DOI":"10.1371\/journal.pone.0090859","article-title":"Circular RNA is expressed across the eukaryotic tree of life","volume":"9","author":"Wang","year":"2014","journal-title":"PLoS One"},{"key":"2022010507351306200_B2","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nature11928","article-title":"Circular RNAs are a large class of animal RNAs with regulatory potency","volume":"495","author":"Memczak","year":"2013","journal-title":"Nature"},{"key":"2022010507351306200_B3","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/nature11993","article-title":"Natural RNA circles function as efficient microRNA 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