{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T19:26:22Z","timestamp":1773861982448,"version":"3.50.1"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T00:00:00Z","timestamp":1632700800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["XDB38030200"],"award-info":[{"award-number":["XDB38030200"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["WX145XQ07-04"],"award-info":[{"award-number":["WX145XQ07-04"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Alliance of International Science Organizations","award":["ANSO-PA-2020-07"],"award-info":[{"award-number":["ANSO-PA-2020-07"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Single-cell bisulfite sequencing methods are widely used to assess epigenomic heterogeneity in cell states. Over the past few years, large amounts of data have been generated and facilitated deeper understanding of the epigenetic regulation of many key biological processes including early embryonic development, cell differentiation and tumor progression. It is an urgent need to build a functional resource platform with the massive amount of data. Here, we present scMethBank, the first open access and comprehensive database dedicated to the collection, integration, analysis and visualization of single-cell DNA\u00a0methylation data and metadata. Current release of scMethBank includes processed single-cell bisulfite sequencing data and curated metadata of 8328 samples derived from 15 public single-cell datasets, involving two species (human and mouse), 29 cell types and two diseases. In summary, scMethBank aims to assist researchers who are interested in cell heterogeneity to explore and utilize whole genome methylation data at single-cell level by providing browse, search, visualization, download functions and user-friendly online tools. The database is accessible at: https:\/\/ngdc.cncb.ac.cn\/methbank\/scm\/.<\/jats:p>","DOI":"10.1093\/nar\/gkab833","type":"journal-article","created":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T14:21:24Z","timestamp":1632406884000},"page":"D380-D386","source":"Crossref","is-referenced-by-count":30,"title":["scMethBank: a database for single-cell whole genome DNA methylation maps"],"prefix":"10.1093","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1834-9684","authenticated-orcid":false,"given":"Wenting","family":"Zong","sequence":"first","affiliation":[{"name":"National Genomics Data Center & CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences,\u00a0Beijing 100101, China"},{"name":"China National Center for Bioinformation, Beijing 100101, China"},{"name":"University of Chinese Academy of Sciences, Beijing 100049, China"}]},{"given":"Hongen","family":"Kang","sequence":"additional","affiliation":[{"name":"National Genomics Data Center & CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences,\u00a0Beijing 100101, China"},{"name":"China National Center for Bioinformation, Beijing 100101, China"},{"name":"University of Chinese Academy of Sciences, Beijing 100049, China"}]},{"given":"Zhuang","family":"Xiong","sequence":"additional","affiliation":[{"name":"National Genomics Data Center & CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences,\u00a0Beijing 100101, China"},{"name":"China National Center for Bioinformation, Beijing 100101, China"},{"name":"University of Chinese Academy of Sciences, Beijing 100049, China"}]},{"given":"Yingke","family":"Ma","sequence":"additional","affiliation":[{"name":"National Genomics Data Center & CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences,\u00a0Beijing 100101, China"},{"name":"China National Center for Bioinformation, Beijing 100101, China"}]},{"given":"Tong","family":"Jin","sequence":"additional","affiliation":[{"name":"National Genomics Data Center & CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences,\u00a0Beijing 100101, China"},{"name":"China National Center for Bioinformation, Beijing 100101, China"},{"name":"University of Chinese Academy of Sciences, Beijing 100049, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7285-2630","authenticated-orcid":false,"given":"Zheng","family":"Gong","sequence":"additional","affiliation":[{"name":"National Genomics Data Center & CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences,\u00a0Beijing 100101, China"},{"name":"China National Center for Bioinformation, Beijing 100101, China"},{"name":"University of Chinese Academy of Sciences, Beijing 100049, China"}]},{"given":"Lizhi","family":"Yi","sequence":"additional","affiliation":[{"name":"National Genomics Data Center & CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences,\u00a0Beijing 100101, China"},{"name":"China National Center for Bioinformation, Beijing 100101, China"}]},{"given":"Mochen","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Genomics Data Center & CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences,\u00a0Beijing 100101, China"},{"name":"China National Center for Bioinformation, Beijing 100101, China"},{"name":"University of Chinese Academy of Sciences, Beijing 100049, China"}]},{"given":"Song","family":"Wu","sequence":"additional","affiliation":[{"name":"National Genomics Data Center & CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences,\u00a0Beijing 100101, China"},{"name":"China National Center for Bioinformation, Beijing 100101, China"},{"name":"University of Chinese Academy of Sciences, Beijing 100049, China"}]},{"given":"Guoliang","family":"Wang","sequence":"additional","affiliation":[{"name":"National Genomics Data Center & CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences,\u00a0Beijing 100101, China"},{"name":"China National Center for Bioinformation, Beijing 100101, China"},{"name":"University of Chinese Academy of Sciences, Beijing 100049, China"}]},{"given":"Yiming","family":"Bao","sequence":"additional","affiliation":[{"name":"National Genomics Data Center & CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences,\u00a0Beijing 100101, China"},{"name":"China National Center for Bioinformation, Beijing 100101, China"},{"name":"University of Chinese Academy of Sciences, Beijing 100049, China"}]},{"given":"Rujiao","family":"Li","sequence":"additional","affiliation":[{"name":"National Genomics Data Center & CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences,\u00a0Beijing 100101, China"},{"name":"China National Center for Bioinformation, Beijing 100101, China"}]}],"member":"286","published-online":{"date-parts":[[2021,9,27]]},"reference":[{"key":"2022010507372875700_B1","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/nrc3130","article-title":"A decade of exploring the cancer epigenome - biological and translational implications","volume":"11","author":"Baylin","year":"2011","journal-title":"Nat. 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The Gene Ontology Consortium","volume":"25","author":"Ashburner","year":"2000","journal-title":"Nat. Genet."},{"key":"2022010507372875700_B26","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1093\/bioinformatics\/bty129","article-title":"BPRMeth: a flexible Bioconductor package for modelling methylation profiles","volume":"34","author":"Kapourani","year":"2018","journal-title":"Bioinformatics"},{"key":"2022010507372875700_B27","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1038\/s41467-021-21583-9","article-title":"Comprehensive analysis of single cell ATAC-seq data with SnapATAC","volume":"12","author":"Fang","year":"2021","journal-title":"Nat. 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