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To utilize these invaluable data for better understanding of COVID-19, additional software should be developed. Especially for researchers without bioinformatic skills, a user-friendly platform is mandatory. We developed the COVID19db platform (http:\/\/hpcc.siat.ac.cn\/covid19db &amp; http:\/\/www.biomedical-web.com\/covid19db) that provides 39 930\u00a0drug\u2013target\u2013pathway interactions and 95 COVID-19 related datasets, which include transcriptomes of 4127 human samples across 13 body sites associated with the exposure of 33 microbes and 33 drugs\/agents. To facilitate data application, each dataset was standardized and annotated with rich clinical information. The platform further provides 14 different analytical applications to analyze various mechanisms underlying COVID-19. Moreover, the 14 applications enable researchers to customize grouping\u00a0and setting for different analyses and allow them to perform analyses using their own data. Furthermore, a Drug Discovery tool is designed to identify potential drugs and targets at whole transcriptomic scale. For proof of concept, we used COVID19db and identified multiple potential drugs and targets for COVID-19. In summary, COVID19db provides user-friendly web interfaces to freely analyze, download data, and submit new data for further integration, it can accelerate the identification of effective strategies against COVID-19.<\/jats:p>","DOI":"10.1093\/nar\/gkab850","type":"journal-article","created":{"date-parts":[[2021,9,11]],"date-time":"2021-09-11T11:09:17Z","timestamp":1631358557000},"page":"D747-D757","source":"Crossref","is-referenced-by-count":42,"title":["COVID19db: a comprehensive database platform to discover potential drugs and targets of COVID-19 at whole transcriptomic scale"],"prefix":"10.1093","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0454-6935","authenticated-orcid":false,"given":"Wenliang","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pediatrics, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong\u00a0518053, China"},{"name":"Shenzhen Institute\u00a0of\u00a0Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong\u00a0518055, China"},{"name":"Department of Bioinformatics, Outstanding Biotechnology Co., Ltd.-Shenzhen, Shenzhen, China"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shenzhen Institute\u00a0of\u00a0Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong\u00a0518055, China"},{"name":"Department of Clinical Oncology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong\u00a0518053, China"}]},{"given":"Zhuochao","family":"Min","sequence":"additional","affiliation":[{"name":"School of Information and Software Engineering, University of Electronic Science and Technology of China, Chengdu\u00a0610054, China"}]},{"given":"Jing","family":"Mo","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics, Outstanding Biotechnology Co., Ltd.-Shenzhen, Shenzhen, China"}]},{"given":"Zhen","family":"Ju","sequence":"additional","affiliation":[{"name":"Shenzhen Institute\u00a0of\u00a0Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong\u00a0518055, China"},{"name":"Center for High Performance Computing, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong\u00a0518055, China"},{"name":"CAS Key Laboratory of Health Informatics, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong\u00a0518055, China"}]},{"given":"Wen","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics, Outstanding Biotechnology Co., Ltd.-Shenzhen, Shenzhen, China"},{"name":"Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Institute of Zoology, Guangdong Academy of Sciences, Guangzhou\u00a0510260, China"}]},{"given":"Binghui","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics, Outstanding Biotechnology Co., Ltd.-Shenzhen, Shenzhen, China"},{"name":"Hospital of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou\u00a0510055, China"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"Shenzhen Institute\u00a0of\u00a0Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong\u00a0518055, China"},{"name":"Department of Clinical Oncology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong\u00a0518053, China"}]},{"given":"Jianliang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong\u00a0518053, China"}]},{"given":"Qianshen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong\u00a0518053, China"}]},{"given":"Hanguang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong\u00a0518053, China"}]},{"given":"Chunxia","family":"Zeng","sequence":"additional","affiliation":[{"name":"Shenzhen Institute\u00a0of\u00a0Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong\u00a0518055, China"},{"name":"Center for High Performance Computing, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong\u00a0518055, China"},{"name":"CAS Key Laboratory of Health Informatics, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong\u00a0518055, China"}]},{"given":"Yanjie","family":"Wei","sequence":"additional","affiliation":[{"name":"Shenzhen Institute\u00a0of\u00a0Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong\u00a0518055, China"},{"name":"Center for High Performance Computing, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong\u00a0518055, China"},{"name":"CAS Key Laboratory of Health Informatics, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong\u00a0518055, China"}]},{"given":"Godfrey Chi-Fung","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong\u00a0518053, China"},{"name":"Department of Pediatrics and Adolescent Medicine, LKS Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong\u00a0999077, China"}]}],"member":"286","published-online":{"date-parts":[[2021,9,23]]},"reference":[{"key":"2022010507401174700_B1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/s41579-020-00468-6","article-title":"Coronavirus biology and replication: implications for SARS-CoV-2","volume":"19","author":"V\u2019Kovski","year":"2021","journal-title":"Nat. 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