{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T18:05:54Z","timestamp":1778263554733,"version":"3.51.4"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T00:00:00Z","timestamp":1632700800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004836","name":"Independent Research Fund Denmark","doi-asserted-by":"publisher","award":["8021-00173B"],"award-info":[{"award-number":["8021-00173B"]}],"id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"publisher","award":["R218-2016-1266"],"award-info":[{"award-number":["R218-2016-1266"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NNF18OC0031226"],"award-info":[{"award-number":["NNF18OC0031226"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hungarian Brain Research Program","award":["2017-1.2.1-NKP-2017-00002"],"award-info":[{"award-number":["2017-1.2.1-NKP-2017-00002"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Two-thirds of signaling substances, several sensory stimuli and over one-third of drugs act via receptors coupling to G proteins. Here, we present an online platform for G protein research with reference data and tools for analysis, visualization and design of scientific studies across disciplines and areas. This platform may help translate new pharmacological, structural and genomic data into insights on G protein signaling vital for human physiology and medicine. The G protein database is accessible at https:\/\/gproteindb.org.<\/jats:p>","DOI":"10.1093\/nar\/gkab852","type":"journal-article","created":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T19:14:34Z","timestamp":1631560474000},"page":"D518-D525","source":"Crossref","is-referenced-by-count":82,"title":["The G protein database, GproteinDb"],"prefix":"10.1093","volume":"50","author":[{"given":"G\u00e1sp\u00e1r","family":"P\u00e1ndy-Szekeres","sequence":"first","affiliation":[{"name":"Department of Drug Design and Pharmacology, University of Copenhagen, 2100 Copenhagen, Denmark"},{"name":"Medicinal Chemistry Research Group, Research Centre\u00a0for Natural Sciences, Budapest H-1117, Hungary"}]},{"given":"Mauricio","family":"Esguerra","sequence":"additional","affiliation":[{"name":"Department of Drug Design and Pharmacology, University of Copenhagen, 2100 Copenhagen, Denmark"}]},{"given":"Alexander S","family":"Hauser","sequence":"additional","affiliation":[{"name":"Department of Drug Design and Pharmacology, University of Copenhagen, 2100 Copenhagen, Denmark"}]},{"given":"Jimmy","family":"Caroli","sequence":"additional","affiliation":[{"name":"Department of Drug Design and Pharmacology, University of Copenhagen, 2100 Copenhagen, Denmark"}]},{"given":"Christian","family":"Munk","sequence":"additional","affiliation":[{"name":"Department of Drug Design and Pharmacology, University of Copenhagen, 2100 Copenhagen, Denmark"}]},{"given":"Steven","family":"Pilger","sequence":"additional","affiliation":[{"name":"Department of Drug Design and Pharmacology, University of Copenhagen, 2100 Copenhagen, Denmark"}]},{"given":"Gy\u00f6rgy\u00a0M","family":"Keser\u0171","sequence":"additional","affiliation":[{"name":"Medicinal Chemistry Research Group, Research Centre\u00a0for Natural Sciences, Budapest H-1117, Hungary"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5514-6021","authenticated-orcid":false,"given":"Albert\u00a0J","family":"Kooistra","sequence":"additional","affiliation":[{"name":"Department of Drug Design and Pharmacology, University of Copenhagen, 2100 Copenhagen, Denmark"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4299-7561","authenticated-orcid":false,"given":"David\u00a0E","family":"Gloriam","sequence":"additional","affiliation":[{"name":"Department of Drug Design and Pharmacology, University of Copenhagen, 2100 Copenhagen, Denmark"}]}],"member":"286","published-online":{"date-parts":[[2021,9,27]]},"reference":[{"key":"2022010507382914000_B1","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.cell.2019.10.010","article-title":"Discovery of human signaling systems: pairing peptides to G protein-coupled receptors","volume":"179","author":"Foster","year":"2019","journal-title":"Cell"},{"key":"2022010507382914000_B2","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/nrd.2017.178","article-title":"Trends in GPCR drug discovery: new agents, targets and indications","volume":"16","author":"Hauser","year":"2017","journal-title":"Nat. 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