{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T02:23:55Z","timestamp":1773887035657,"version":"3.50.1"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T00:00:00Z","timestamp":1633910400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Tou-Yan Innovation Team Program of the Heilongjiang Province","award":["2019-15"],"award-info":[{"award-number":["2019-15"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61871160"],"award-info":[{"award-number":["61871160"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62172130"],"award-info":[{"award-number":["62172130"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Young Innovative Talents in Colleges and Universities of Heilongjiang Province","award":["2018-69"],"award-info":[{"award-number":["2018-69"]}]},{"name":"Heilongjiang Postdoctoral Fund","award":["LBH-Q20030"],"award-info":[{"award-number":["LBH-Q20030"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>SCovid (http:\/\/bio-annotation.cn\/scovid) aims at providing a comprehensive resource of single-cell data for exposing molecular characteristics of coronavirus disease 2019 (COVID-19) across 10 human tissues. COVID-19, an epidemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been found to be accompanied with multiple-organ failure since its first report in Dec 2019. To reveal tissue-specific molecular characteristics, researches regarding to COVID-19 have been carried out widely, especially at single-cell resolution. However, these researches are still relatively independent and scattered, limiting the comprehensive understanding of the impact of virus on diverse tissues. To this end, we developed a single-cell atlas of COVID-19. Firstly we collected 21 single-cell datasets of COVID-19 across 10 human tissues paired with control datasets. Then we constructed a pipeline for the analysis of these datasets to reveal molecular characteristics of COVID-19 based on manually annotated cell types. The current version of SCovid documents 1 042 227 single cells of 21 single-cell datasets across 10 human tissues, 11 713 stably expressed genes and 3778 significant differentially expressed genes (DEGs). SCovid provides a user-friendly interface for browsing, searching, visualizing and downloading all detailed information.<\/jats:p>","DOI":"10.1093\/nar\/gkab881","type":"journal-article","created":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T18:07:36Z","timestamp":1633370856000},"page":"D867-D874","source":"Crossref","is-referenced-by-count":34,"title":["SCovid: single-cell atlases for exposing molecular characteristics of COVID-19 across 10 human tissues"],"prefix":"10.1093","volume":"50","author":[{"given":"Changlu","family":"Qi","sequence":"first","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China"}]},{"given":"Chao","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2808-3771","authenticated-orcid":false,"given":"Lingling","family":"Zhao","sequence":"additional","affiliation":[{"name":"Faculty of Computing, Harbin Institute of Technology, Harbin, Heilongjiang\u00a0150001, China"}]},{"given":"Zijun","family":"Zhu","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China"}]},{"given":"Ping","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China"}]},{"given":"Sainan","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6665-6710","authenticated-orcid":false,"given":"Liang","family":"Cheng","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China"},{"name":"NHC and CAMS Key Laboratory of Molecular Probe and Targeted Theranostics, Harbin Medical University, Harbin, Heilongjiang 150028, China"}]},{"given":"Xue","family":"Zhang","sequence":"additional","affiliation":[{"name":"NHC and CAMS Key Laboratory of Molecular Probe and Targeted Theranostics, Harbin Medical University, Harbin, Heilongjiang 150028, China"},{"name":"McKusick-Zhang Center for Genetic Medicine, Peking Union Medical College, Beijing 100005, China"}]}],"member":"286","published-online":{"date-parts":[[2021,10,11]]},"reference":[{"key":"2022010507371339500_B1","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1007\/s11606-020-05762-w","article-title":"Review of the clinical characteristics of coronavirus disease 2019 (COVID-19)","volume":"35","author":"Jiang","year":"2020","journal-title":"J. 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