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Most currently available signaling databases contain only a part of the complex network of intertwining pathways, leaving out key interactions or processes. Hence, we have developed SignaLink3 (http:\/\/signalink.org\/), a value-added knowledge-base that provides manually curated data on signaling pathways and integrated data from several types of databases (interaction, regulation, localisation, disease, etc.) for humans, and three major animal model organisms. SignaLink3 contains over 400 000 newly added human protein-protein interactions resulting in a total of 700 000 interactions for Homo sapiens, making it one of the largest integrated signaling network resources. Next to H. sapiens, SignaLink3 is the only current signaling network resource to provide regulatory information for the model species Caenorhabditis elegans and Danio rerio, and the largest resource for Drosophila melanogaster. Compared to previous versions, we have integrated gene expression data as well as subcellular localization of the interactors, therefore uniquely allowing tissue-, or compartment-specific pathway interaction analysis to create more accurate models. Data is freely available for download in widely used formats, including CSV, PSI-MI TAB or SQL.<\/jats:p>","DOI":"10.1093\/nar\/gkab909","type":"journal-article","created":{"date-parts":[[2021,9,22]],"date-time":"2021-09-22T19:21:18Z","timestamp":1632338478000},"page":"D701-D709","source":"Crossref","is-referenced-by-count":42,"title":["SignaLink3: a multi-layered resource to uncover tissue-specific signaling networks"],"prefix":"10.1093","volume":"50","author":[{"given":"Luca","family":"Csabai","sequence":"first","affiliation":[{"name":"Earlham Institute, Norwich\u00a0NR4 7UZ, UK"},{"name":"Department of Genetics, ELTE E\u00f6tv\u00f6s Lor\u00e1nd University, Budapest\u00a0H-1117, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e1vid","family":"Fazekas","sequence":"additional","affiliation":[{"name":"Earlham Institute, Norwich\u00a0NR4 7UZ, UK"},{"name":"Department of Genetics, ELTE E\u00f6tv\u00f6s Lor\u00e1nd University, Budapest\u00a0H-1117, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam\u00e1s","family":"Kadlecsik","sequence":"additional","affiliation":[{"name":"Department of Genetics, ELTE E\u00f6tv\u00f6s Lor\u00e1nd University, Budapest\u00a0H-1117, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1t\u00e9","family":"Szalay-Bek\u0151","sequence":"additional","affiliation":[{"name":"Earlham Institute, Norwich\u00a0NR4 7UZ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bal\u00e1zs","family":"Boh\u00e1r","sequence":"additional","affiliation":[{"name":"Earlham Institute, Norwich\u00a0NR4 7UZ, UK"},{"name":"Department of Genetics, ELTE E\u00f6tv\u00f6s Lor\u00e1nd University, Budapest\u00a0H-1117, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Madgwick","sequence":"additional","affiliation":[{"name":"Earlham Institute, Norwich\u00a0NR4 7UZ, UK"},{"name":"Gut Microbes and Health Programme, Quadram 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