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Recently, the NPs have emerged as the ideal candidates to combine with other therapeutic strategies to deal with the persistent challenge of conventional therapy, and the molecular regulation mechanism underlying these combinations is crucial for the related communities. Thus, it is urgently demanded to comprehensively provide the disease-specific molecular regulation data for various NP-based drug combinations. However, no database has been developed yet to describe such valuable information. In this study, a newly developed database entitled \u2018Natural Product-based Drug Combination and Its Disease-specific Molecular Regulation (NPCDR)\u2019 was thus introduced. This database was unique in (a) providing the comprehensive information of NP-based drug combinations &amp; describing their clinically or experimentally validated therapeutic effect, (b) giving the disease-specific molecular regulation data for a number of NP-based drug combinations, (c) fully referencing all NPs, drugs, regulated molecules\/pathways by cross-linking them to the available databases describing their biological or pharmaceutical characteristics. Therefore, NPCDR is expected to have great implications for the future practice of network pharmacology, medical biochemistry, drug design, and medicinal chemistry. This database is now freely accessible without any login requirement at both official (https:\/\/idrblab.org\/npcdr\/) and mirror (http:\/\/npcdr.idrblab.net\/) sites.<\/jats:p>","DOI":"10.1093\/nar\/gkab913","type":"journal-article","created":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T20:48:32Z","timestamp":1633034912000},"page":"D1324-D1333","source":"Crossref","is-referenced-by-count":36,"title":["NPCDR: natural product-based drug combination and its disease-specific molecular regulation"],"prefix":"10.1093","volume":"50","author":[{"given":"Xueni","family":"Sun","sequence":"first","affiliation":[{"name":"School of Pharmacy and Department of Medical Oncology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou 311121, China"}]},{"given":"Yintao","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China"}]},{"given":"Ying","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Disease, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang Provincial Key Laboratory for Drug Clinical Research and Evaluation, The First Affiliated Hospital, Zhejiang University,\u00a079 QingChun Road, Hangzhou, Zhejiang 310000, China"}]},{"given":"Xichen","family":"Lian","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China"}]},{"given":"Lili","family":"Yan","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Department of Medical Oncology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou 311121, China"}]},{"given":"Ting","family":"Pan","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Department of Medical Oncology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou 311121, China"}]},{"given":"Ting","family":"Jin","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Department of Medical Oncology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou 311121, China"}]},{"given":"Han","family":"Xie","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Department of Medical Oncology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou 311121, China"}]},{"given":"Zimao","family":"Liang","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Department of Medical Oncology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou 311121, China"}]},{"given":"Wenqi","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Surgery, HKU-SZH & Faculty of Medicine, The University of Hong Kong, Hong Kong, China"}]},{"given":"Jianxin","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Computer Science and Engineering, Central South University, Changsha 410083, China"}]},{"given":"Zhaorong","family":"Li","sequence":"additional","affiliation":[{"name":"Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Alibaba-Zhejiang University Joint Research Center of Future Digital Healthcare, Hangzhou 330110, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8069-0053","authenticated-orcid":false,"given":"Feng","family":"Zhu","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China"},{"name":"Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Alibaba-Zhejiang University Joint Research Center of Future Digital Healthcare, Hangzhou 330110, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7330-0467","authenticated-orcid":false,"given":"Xinbing","family":"Sui","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Department of Medical Oncology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou 311121, China"}]}],"member":"286","published-online":{"date-parts":[[2021,10,19]]},"reference":[{"key":"2022010507400219100_B1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nrd4510","article-title":"The re-emergence of natural products for drug discovery in the genomics era","volume":"14","author":"Harvey","year":"2015","journal-title":"Nat. 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