{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T05:51:37Z","timestamp":1768456297749,"version":"3.49.0"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T00:00:00Z","timestamp":1634083200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32100534"],"award-info":[{"award-number":["32100534"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010104","name":"Tianjin Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010104","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Alternative polyadenylation (APA) has been widely recognized as a crucial step during the post-transcriptional regulation of eukaryotic genes. Recent studies have demonstrated that APA exerts key regulatory roles in many biological processes and often occurs in a tissue- and cell-type-specific manner. However, to our knowledge, there is no database incorporating information about APA at the cell-type level. Single-cell RNA-seq is a rapidly evolving and powerful tool that enable APA analysis at the cell-type level. Here, we present a comprehensive resource, scAPAatlas (http:\/\/www.bioailab.com:3838\/scAPAatlas), for exploring APA across different cell types, and interpreting potential biological functions. Based on the curated scRNA-seq data from 24 human and 25 mouse normal tissues, we systematically identified cell-type-specific APA events for different cell types and examined the correlations between APA and gene expression level. We also estimated the crosstalk between cell-type-specific APA events and microRNAs or RNA-binding proteins. A user-friendly web interface has been constructed to support browsing, searching and visualizing multi-layer information of cell-type-specific APA events. Overall, scAPAatlas, incorporating a rich resource for exploration of APA at the cell-type level, will greatly help researchers chart cell type with APA and elucidate the biological functions of APA.<\/jats:p>","DOI":"10.1093\/nar\/gkab917","type":"journal-article","created":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T20:48:32Z","timestamp":1633034912000},"page":"D356-D364","source":"Crossref","is-referenced-by-count":16,"title":["scAPAatlas: an atlas of alternative polyadenylation across cell types in human and mouse"],"prefix":"10.1093","volume":"50","author":[{"given":"Xiaoxiao","family":"Yang","sequence":"first","affiliation":[{"name":"The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin Key Laboratory of Inflammation Biology, Tianjin Key Laboratory of Medical Epigenetics, Department of Pharmacology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China"},{"name":"Department of Bioinformatics,\u00a0School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China"}]},{"given":"Yang","family":"Tong","sequence":"additional","affiliation":[{"name":"The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin Key Laboratory of Inflammation Biology, Tianjin Key Laboratory of Medical Epigenetics, Department of Pharmacology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China"},{"name":"Department of Bioinformatics,\u00a0School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China"}]},{"given":"Gerui","family":"Liu","sequence":"additional","affiliation":[{"name":"The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin Key Laboratory of Inflammation Biology, Tianjin Key Laboratory of Medical Epigenetics, Department of Pharmacology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China"},{"name":"Department of Bioinformatics,\u00a0School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China"}]},{"given":"Jiapei","family":"Yuan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union\u00a0Medical College, Tianjin 300020, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0273-9242","authenticated-orcid":false,"given":"Yang","family":"Yang","sequence":"additional","affiliation":[{"name":"The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin Key Laboratory of Inflammation Biology, Tianjin Key Laboratory of Medical Epigenetics, Department of Pharmacology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China"},{"name":"Department of Bioinformatics,\u00a0School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China"}]}],"member":"286","published-online":{"date-parts":[[2021,10,13]]},"reference":[{"key":"2022010507380880500_B1","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/nrm.2016.116","article-title":"Alternative polyadenylation of mRNA precursors","volume":"18","author":"Tian","year":"2017","journal-title":"Nat. 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