{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T17:46:39Z","timestamp":1772127999451,"version":"3.50.1"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T00:00:00Z","timestamp":1635379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["KYXK2021006"],"award-info":[{"award-number":["KYXK2021006"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000199","name":"USDA","doi-asserted-by":"publisher","award":["MICL02560"],"award-info":[{"award-number":["MICL02560"]}],"id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007709","name":"Michigan State University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007709","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>RNA-seq has been widely used in experimental studies and produced a massive amount of data deposited in public databases. New biological insights can be obtained by retrospective analyses of previously published data. However, the barrier to efficiently utilize these data remains high, especially for those who lack bioinformatics skills and computational resources. We present MetazExp (https:\/\/bioinfo.njau.edu.cn\/metazExp), a database for gene expression and alternative splicing profiles based on 53 615 uniformly processed publicly available RNA-seq samples from 72 metazoan species. The gene expression and alternative splicing profiles can be conveniently queried by gene IDs, symbols, functional terms and sequence similarity. Users can flexibly customize experimental groups to perform differential and specific expression and alternative splicing analyses. A suite of data visualization tools and comprehensive links with external databases allow users to efficiently explore the results and gain insights. In conclusion, MetazExp is a valuable resource for the research community to efficiently utilize the vast public RNA-seq datasets.<\/jats:p>","DOI":"10.1093\/nar\/gkab933","type":"journal-article","created":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T16:00:32Z","timestamp":1633017632000},"page":"D1046-D1054","source":"Crossref","is-referenced-by-count":11,"title":["MetazExp: a database for gene expression and alternative splicing profiles and their analyses based on 53 615 public RNA-seq samples in 72 metazoan species"],"prefix":"10.1093","volume":"50","author":[{"given":"Jinding","family":"Liu","sequence":"first","affiliation":[{"name":"College of Information Management, Nanjing Agricultural University, Nanjing, Jiangsu 210095, China"},{"name":"Research Center for Correlation of Domain Knowledge, Nanjing Agricultural University, Nanjing, Jiangsu 210095, China"},{"name":"Department of Animal Science, Michigan State University, East Lansing, MI 48824, USA"}]},{"given":"Fei","family":"Yin","sequence":"additional","affiliation":[{"name":"Research Center for Correlation of Domain Knowledge, Nanjing Agricultural University, Nanjing, Jiangsu 210095, China"}]},{"given":"Kun","family":"Lang","sequence":"additional","affiliation":[{"name":"College of Information Management, Nanjing Agricultural University, Nanjing, Jiangsu 210095, China"},{"name":"Research Center for Correlation of Domain Knowledge, Nanjing Agricultural University, Nanjing, Jiangsu 210095, China"}]},{"given":"Wencai","family":"Jie","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu 210023, China"}]},{"given":"Suxu","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Michigan State University, East Lansing, MI 48824, USA"}]},{"given":"Rongjing","family":"Duan","sequence":"additional","affiliation":[{"name":"Academy for Advanced Interdisciplinary Studies, Nanjing Agricultural University, Nanjing, Jiangsu 210095, China"}]},{"given":"Shuiqing","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Information Management, Nanjing Agricultural University, Nanjing, Jiangsu 210095, China"},{"name":"Research Center for Correlation of Domain Knowledge, Nanjing Agricultural University, Nanjing, Jiangsu 210095, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6788-8364","authenticated-orcid":false,"given":"Wen","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Michigan State University, East Lansing, MI 48824, USA"}]}],"member":"286","published-online":{"date-parts":[[2021,10,28]]},"reference":[{"key":"2022010507424253100_B1","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/nbt.1621","article-title":"Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation","volume":"28","author":"Trapnell","year":"2010","journal-title":"Nat. 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