{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:41:33Z","timestamp":1772138493633,"version":"3.50.1"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T00:00:00Z","timestamp":1635379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Abdullah Gul University Scientific Research Project","award":["TOA-2018-110"],"award-info":[{"award-number":["TOA-2018-110"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The availability of genetic variants, together with phenotypic annotations from model organisms, facilitates comparing these variants with equivalent variants in humans. However, existing databases and search tools do not make it easy to scan for equivalent variants, namely \u2018matching variants\u2019 (MatchVars) between humans and other organisms. Therefore, we developed an integrated search engine called ConVarT (http:\/\/www.convart.org\/) for matching variants between humans, mice, and Caenorhabditis elegans. ConVarT incorporates annotations (including phenotypic and pathogenic) into variants, and these previously unexploited phenotypic MatchVars from mice and C. elegans can give clues about the functional consequence of human genetic variants. Our analysis shows that many phenotypic variants in different genes from mice and C. elegans, so far, have no counterparts in humans, and thus, can be useful resources when evaluating a relationship between a new human mutation and a disease.<\/jats:p>","DOI":"10.1093\/nar\/gkab939","type":"journal-article","created":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T19:40:58Z","timestamp":1634326858000},"page":"D1172-D1178","source":"Crossref","is-referenced-by-count":26,"title":["ConVarT: a search engine for matching human genetic variants with variants from non-human species"],"prefix":"10.1093","volume":"50","author":[{"given":"Mustafa S","family":"Pir","sequence":"first","affiliation":[{"name":"Rare Disease Laboratory, School of Life and Natural Sciences, Abdullah Gul University, Kayseri\u00a038090, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Halil I","family":"Bilgin","sequence":"additional","affiliation":[{"name":"Department of Computer Engineering, Abdullah Gul University, Kayseri\u00a038090, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8765-1791","authenticated-orcid":false,"given":"Ahmet","family":"Sayici","sequence":"additional","affiliation":[{"name":"Department of Computer Engineering, Abdullah Gul University, Kayseri\u00a038090, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatih","family":"Co\u015fkun","sequence":"additional","affiliation":[{"name":"Department of Computer Engineering, Abdullah Gul University, Kayseri\u00a038090, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0859-4598","authenticated-orcid":false,"given":"Furkan M","family":"Torun","sequence":"additional","affiliation":[{"name":"Rare Disease Laboratory, School of Life and Natural Sciences, Abdullah Gul University, Kayseri\u00a038090, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei","family":"Zhao","sequence":"additional","affiliation":[{"name":"SunyBiotech Co., Ltd, Fuzhou 35000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yahong","family":"Kang","sequence":"additional","affiliation":[{"name":"SunyBiotech Co., Ltd, Fuzhou 35000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebiha","family":"Cevik","sequence":"additional","affiliation":[{"name":"Rare Disease Laboratory, School of Life and Natural Sciences, Abdullah Gul University, Kayseri\u00a038090, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8733-0920","authenticated-orcid":false,"given":"Oktay\u00a0I","family":"Kaplan","sequence":"additional","affiliation":[{"name":"Rare Disease Laboratory, School of Life and Natural Sciences, Abdullah Gul University, Kayseri\u00a038090, 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